Magnesium lithospermate B is excreted rapidly into rat bile mostly methylated metabolites, which are potent antioxidants

Drug Metabolism and Disposition

Volumn 32, Issue 7, 2004, Pages 752-757

  Zhang, Ying ^a   Akao, Teruaki ^a   Nakamura, Norio ^a   Hattori, Masao ^a   Yang, Xiu Wei ^b   Duan, Chang Ling ^b   Liu, Jian Xun ^b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 3 METHYLLITHOSPERMIC ACID B; 3,3'' DIMETHYLLITHOSPERMIC ACID B; 3,3''' DIMETHYLLITHOSPERMIC ACID B; 3,3'',3''' TRIMETHYLLITHOSPERMIC ACID B; ALPHA TOCOPHEROL; ANTIOXIDANT; CAFFEIC ACID; DRUG METABOLITE; MAGNESIUM LITHOSPERMATE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOTRANSFORMATION; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BILE LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG EXCRETION; DRUG METABOLISM; DRUG TRANSFORMATION; ENTEROHEPATIC CIRCULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIVER CYTOSOL; MALE; MASS SPECTROMETRY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM CHEMISTRY; RAT; SALVIA MILTIORRHIZA;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FREE RADICAL SCAVENGERS; INJECTIONS, INTRAVENOUS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, WISTAR; TIME FACTORS;

ANIMALIA; SALVIA; SALVIA MILTIORRHIZA;

EID: 3042634920     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.7.752     Document Type: Article

References (25)

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