The ability of three global plasma assays to recognize thrombophilia

Thrombosis Research

Volumn 113, Issue 6, 2004, Pages 411-417

  Andresen, Marianne S ^a   Abildgaard, Ulrich ^a   Liestøl, Sigurd ^b   Sandset, Per Morten ^b   Mowinckel, Marie Christine ^b   Ødegaard, Ole Rasmus ^a   Larsen, Mette Lie ^a   Diep, Lien My ^a  

^a AKER UNIVERSITY HOSPITAL   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

ABS; absorbance; activated partial thromboplastin time; Antithrombin; antithrombin; APTT; area under the curve; AT; AUC; CIP; Coagulation; Coagulation Inhibitor Potential; FV Leiden; Protein C; Protein S; Thrombin; Thrombophilia; Venous thromboembolism

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; PROTEIN C; PROTEIN S;

ADOLESCENT; ADULT; AGED; ANTICOAGULATION; ANTITHROMBIN DEFICIENCY; ARTICLE; AUTOMATION; BLOOD CLOTTING TEST; BLOOD SAMPLING; CALIBRATED AUTOMATED THROMBOGRAM; CALIBRATION; CLINICAL ARTICLE; CLINICAL TRIAL; COAGULATION INHIBITOR POTENTIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYOPRESERVATION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; GENE MUTATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INHERITANCE; INTERMETHOD COMPARISON; MALE; PRIORITY JOURNAL; PROC GLOBAL ASSAY; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RECEIVER OPERATING CHARACTERISTIC; SCREENING TEST; THROMBOPHILIA;

EID: 3042634243     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2004.05.002     Document Type: Article

References (22)

1. Crowther M.A., Kelton J.G. Congenital thrombophilic states associated with venous thrombosis: a qualitative overview and proposed classification system. Ann. Intern. Med. 138:2003;128-149
2. Seligsohn U., Lubetsky A. Genetic susceptibility to venous thrombosis. N. Engl. J. Med. 344:2001;1222-1231
3. Tripodi A., Manucci P.M. Laboratory investigation of thrombophilia. Clin. Chem. 47:2001;1597-1606
4. Bauer K.A., Rosendaal F.R., Heit J.A. Hypercoagulability: too many tests, too much conflicting data. Hematology. 1:2002;353-371
5. Bauer K.A. Management of thrombophilia. Thromb. Haemost. 1:2003;1429-1434
6. Wielders S., Mukherjee M., Michiels J., Rijkers D.T.S., Cambus J.P., Knebel R.W.C., et al. The routine determination of the endogenous thrombin potential, first results in different forms of hyper- and hypocoagulability. Thromb. Haemost. 77:1997;629-636
7. Kyrle P.A., Mannhalter C., Beguin S., Stumpflen A., Hirschl M., Weltermann A., et al. Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene. Arterioscler. Thromb. Vasc. Biol. 18:1998;1287-1291
8. Toulon P., Adda R., Perez P. Sensitivity of the ProC Global assay for protein C pathway abnormalities. Clinical experience in 899 unselected patients with venous thromboembolism. Thromb. Res. 104:2001;93-103
9. He S., Bremme K., Blombäck M. A laboratory method for determination of overall haemostatic potential in plasma: I. Method design and preliminary results. Thromb. Res. 96:1999;145-156
10. Andresen M.S., Iversen N., Abildgaard U. Overall haemostasis potential assays performed in thrombophilic plasma: the effect of preactivating protein C and antithrombin. Thromb. Res. 15:2002;323-327
11. Ødegaard O.R., Li M., Abildgaard U. Antifactor Xa activity measured with amidolytic methods. Haemostasis. 5:1976;265-275
12. Ødegaard O.R., Try K., Andersson T.R. Protein C: an automated assay. Haemostasis. 17:1987;109-113
13. Wolf M., Boyer-Neumann C., Martinoli J.-L., Leroy-Matheron C., Amiral J., Meyer D. An new functional assay for human protein S activity using activated factor V as a substrate. Thromb. Haemost. 62:1989;1144-1145
14. Bertina R.M. Factor V Leiden and other coagulation factor mutations affecting thrombotic risk. Clin. Chem. 43:1997;1678-1683
15. Hemker H.C., Giesen P.L.A., Ramjee M., Wagenwoord R., Beguin S. The thrombogram: monitoring thrombin generation in platelet rich plasma. Thromb. Haemost. 83:2000;589-591
16. Kraus M., Noah M., Fickenscher K. The PCAT - a simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Thromb. Res. 79:1995;217-222
17. He S., Antovic A., Blombäck M. A simple and rapid laboratory method for determination of haemostasis potential in plasma: II. Modifications for use in routine laboratories and research work. Thromb. Res. 103:2001;355-361
18. Walker I.D. Thrombophilia in pregnancy. J. Clin. Pathol. 53:2000;573-580
19. Martinelli I., Lengnani C., Bucciarelli P., Grandone E., De Stefano V., Mannucci P.M. Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia. Thromb. Haemost. 86:2001;800-803
20. Middeldorp S., Meinardi J.R., Koopman M.M.W., van Pampus E.C.M., Hamulyak K., van der Meer J., et al. A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism. Ann. Intern. Med. 135:2001;322-327
21. Hemker H.C., Beguin S. Phenotyping the clotting system. Thromb. Haemost. 84:2000;747-751
22. Duchemin J., Pittet J.-L., Tartary M., Beguin S., Gaussem P., Alhenc-Gelas M., et al. A new assay based on thrombin generation inhibition to detect both protein C and protein S deficiencies in plasma. Thromb. Haemost. 71:1994;331-338