Antitumoral effects of annonaceous acetogenins

Chinese Pharmacological Bulletin

Volumn 20, Issue 3, 2004, Pages 245-247

  Li, Yan Fang ^a   Fu, Li Wu ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Annonaceous acetogenins; Intitumoral effect

Indexed keywords

ACETOGENIN; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ASIMICIN; ATEMOYACIN A; BULLATACIN; CYTOTOXIC AGENT; GLYCOPROTEIN P; HERBACEOUS AGENT; PESTICIDE; SQUAMOCIN; TRILOBACIN; TRILOBIN; UNCLASSIFIED DRUG;

ANNONACEAE; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HERBAL MEDICINE; HUMAN; IC 50; MULTIDRUG RESISTANCE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 3042632337     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Alali FQ, Liu XX, Mclaughlin JL. Annonaceous acetogenins: Recent progress. J Nat Prod, 1999;62(3):504-40
2. Yazbak A, Sinha SC, Keinan E. Total synthesis of Uvaricin. J Org Chem, 1998;63(17):5863-8
3. Alali FQ, Rogers L, Zhang Y, McLaughlin JL. Goniotriocin and (2,4-cis-and-trans)-xylomaticinones, bioactive annonaceous acetogenins from goniothalamusgiganteus. J Nat Prod, 1999; 62(1):31-4
4. Wang LQ, Min BS, Li Y et al. Annonaceous acetogenins from the leaves of annona montana. Bioorg Med Chem, 2002;10(3): 561-5
5. Li DY, Yu JG, Zhu JX et al. Annonaceous acetogenins of the seeds fron annona muricata. J Asian Nat Prod Res, 2001;3 (4):267-76
6. Hopp DC, Zeng L, Gu ZM et al. Novel mono-tetrahydrofuran ring acetogenins from the bark of annona squamosa, showing cytotoxic selectivities for the human pancreatic carcinoma cell line, PACA-2. J Nat Prod, 1997;60(6):581-6
7. Morro DJ, de Cabo R, Farley C et al. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of Hela and HL-60, but not liver, plasma membranes. Life Sciences, 1995;56(5):343-8
8. Hopp DC, Zeng L, Gu Z, Mclaughlin JL. Squamotacin: An annonoaceos acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3). J Nat Prod, 1996;59(2):97-9
9. Kuwabara K, Takada M, Iwata J et al. Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics. Eur J Biochem, 2000;267(9):2538-46
10. Yuan SS, Chang HL, Chen HW et al. Annonacin, a mono-tetrahydrofuran a cerogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax-and caspase-3-related pathway. Life Sciences, 2003;72(25):2853-61
11. Queiroz EF, Roblot F, Duret P et al. Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy. J Med Chem, 2000;43(8): 1604-10
12. Raynaud S, Nemati F, Miccoli L et al. Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines. Life Sci, 1999;65(5):525-33
13. Chiu HF, T Chih TT, Hsian YM et al. Bullatacin, a potent antitumor annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human heparoma 2.2. 15 cells. Biochem Pharmacol, 2003;65(3):319-27
14. Takada M, Kuwabara K, Nakato H et al. Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I. Biochim Biophys Acta, 2000;1460(2-3):302-10
15. Miyoshi H. Ohshima M, Shimada H et al. Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondral complex I. Biochim Biophys Acta, 1998;1365(3):443-52