Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation

Modern Pathology

Volumn 17, Issue 7, 2004, Pages 868-873

  Nogales, Francisco F ^a,d   Musto, Maria L ^b   Sáez, Ana I ^a   Robledo, Mercedes ^c   Palacios, José ^c   Aneiros, José ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^b UNIVERSIDAD DE MONTEVIDEO   (Uruguay)

^c Servicio de Enferemdades Infecciosas   (Spain)

^d UNIVERSITY OF GRANADA   (Spain)

Author keywords

Childhood malignant adrenocortical tumor; Granulosa cell tumor; Li Fraumeni syndrome; p53 gene mutation

Indexed keywords

HYALIN; PROTEIN P53;

ADRENAL CORTEX TUMOR; ADULT; ARTICLE; BREAST CARCINOMA; CANCER INVASION; CASE REPORT; CELL NUCLEUS; CHILDHOOD CANCER; CYSTOSARCOMA PHYLLOIDES; ENDOMETRIUM CARCINOMA; ENDOMETRIUM TUMOR; FAMILIAL CANCER; FEMALE; GENE MUTATION; GERM LINE; GRANULOSA CELL TUMOR; HUMAN; HUMAN TISSUE; LEIOMYOSARCOMA; LIPOSARCOMA; MITOSIS; MULTIFOCAL INTRAFOLLICULAR OVARY GRANULOSA CELL TUMOR; MULTIPLE CANCER; MYOMA; OSTEOSARCOMA; OVARY FOLLICLE; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN DOMAIN; RETICULOHISTIOCYTOSIS; STOP CODON; STROMA; TELANGIECTASIA; TELANGIECTATIC OSTEOSARCOMA;

ADULT; BASE SEQUENCE; CODON, NONSENSE; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GERM-LINE MUTATION; GRANULOSA CELL TUMOR; HUMANS; IMMUNOHISTOCHEMISTRY; MUTAGENESIS, INSERTIONAL; OVARIAN FOLLICLE; OVARIAN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 3042628327     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800133     Document Type: Article

References (19)

1. Birch JM, Alston RD, McNally RJ, et al. Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene 2001;20:4621-4628.
2. Li FP, Fraumeni Jr JF. Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 1969;71:747-752.
3. Varley JM. Germline TP53 mutations and Li-Fraumeni syndrome. Hum Mutat 2003;21:313-320.
4. Schuijer M, Berns EM. TP53 and ovarian cancer. Hum Mutat 2003;21:285-291.
5. The IARC TP53 mutation database. http://www.iarc.fr/ P53/. Last update: October 28 2003.
6. Ribeiro RC, Sandrini F, Figueiredo B, et al. An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. Proc Natl Acad Sci USA 2001;98:9330-9335.
7. Urioste M, Martinez-Ramirez A, Cigudosa JC, et al. Complex abnormalities including telomeric associations and MEN1 mutation in a pediatric ependymoma. Cancer Genet Cytogenet 2002;138:107-110.
8. Gebhart JB, Roche PC, Keeney GL, et al. Assessment of inhibin and p53 in granulosa cell tumors of the ovary. Gynecol Oncol 2000;77:232-236.
9. Mayr D, Kaltz-Wittmer C, Arbogast S, et al. Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors. Mod Pathol 2002;15:951-957.
10. Chompret A. The Li-Fraumeni syndrome. Biochimie 2002;84:75-82.
11. Kleihues P, Schauble B, Zur Hausen A, et al. Tumors associated with p53 germline mutations: a synopsis of 91 families. Am J Pathol 1997;150:1-13.
12. Kupryjanczyk J, Thor AD, Beauchamp R, et al. p53 gene mutations and protein accumulation in human ovarian cancer. Proc Natl Acad Sci USA 1993;90:4961-4965.
13. McDougal WS. An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. J Urol 2002;168:1289.
14. Varley JM, McGown G, Thorncroft M, et al. Are there low-penetrance TP53 Alleles? Evidence from childhood adrenocortical tumors. Am J Hum Genet 1999;55:995-1006.
15. Papadimitriou JC, Drachenberg CB, Brenner DS, et al. 'Thanatosomes': a unifying morphogenetic concept for tumor hyaline globules related to apoptosis. Hum Pathol 2000;31:1455-1465.
16. Young RH, Scully RE. Ovarian sex cord-stromal tumors with bizarre nuclei: a clinicopathologic analysis of 17 cases. Int J Gynecol Pathol 1983;1:325-335.
17. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary. A clinicopathological analysis of 125 cases. Am J Surg Pathol 1984;8:575-596.
18. Velasco A, Alonso A, Blanco A, et al. Ollier's disease associated with ovarian juvenile granulosa cell tumor. Report of a case and literature review. Cancer 1988;62:222-225.
19. Silverberg SG, Kurman RJ, Nogales FF, et al. Epithelial tumours and related lesions of the uterine corpus. In: Tavassoli FA and Stratton MR (eds). WHO Classification of Tumours. III. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC: Lyon, 2003, pp 230-232.