Effect of medetomidine on breathing and inspiratory neuromuscular drive in conscious dogs

American Journal of Veterinary Research

Volumn 65, Issue 6, 2004, Pages 720-724

  Lerche, Phillip ^a   Muir III, William W ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CARBON DIOXIDE; MEDETOMIDINE; OXYGEN;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ARTICLE; BREATHING; BREATHING RATE; CENTRAL NERVOUS SYSTEM DEPRESSION; CONSCIOUSNESS; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG MECHANISM; END TIDAL CARBON DIOXIDE TENSION; FEMALE; FORCED EXPIRATORY FLOW; LUNG MINUTE VOLUME; MALE; MONITORING; NEUROMUSCULAR FUNCTION; NONHUMAN; RESPIRATION DEPRESSION; RESPIRATORY DRIVE; TIDAL VOLUME;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CARBON DIOXIDE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAVENOUS; MEDETOMIDINE; PRESSURE; RESPIRATION; TIDAL VOLUME; TIME FACTORS; TRANSDUCERS, PRESSURE;

ANIMALIA; CANIS FAMILIARIS;

EID: 3042627479     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2004.65.720     Document Type: Article

References (20)

1. Virtanen R. Pharmacological profiles of medetomidine and its antagonist atipamezole. Acta Vet Scand 1989;85:29-37.
2. Clarke KW, England GC. Medetomidine, a new sedative-analgesic for use in the dog and its reversal with atipamezole. J Small Anim Pract 1989;30:343-348.
3. Vainio O. Introduction to the clinical pharmacology of medetomidine. Acta Vet Scand 1989;85:179-186.
4. Elam M, Yao T, Thorén P, et al. Hypercapnia and hypoxia: chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves. Brain Res 1981;222:373-381.
5. Haskins SC, Patz JD, Farver TB. Xylazine and xylazine-ketamine in dogs. Am J Vet Res 1986;47:636-641.
6. Simon F, Romváry A, Mora S. Clinical investigations of medetomidine in dogs. Acta Vet Scand 1989;85:161-165.
7. Räihä JE, Räihä MP Short CE. Comparison of three different dose regimes of medetomidine in laboratory Beagles. Acta Vet Scand 1989;85:111-116.
8. 2-adrenergic agonist, on ventilatory drive in the dog. Acta Vet Scand 1989;85:65-70.
9. Whitelaw WA, Derenne JP. Airway occlusion pressure. J Appl Physiol 1993;74:1475-1483.
10. Ward SA, Aqleh KA, Poon CS. Breath-to-breath monitoring of inspiratory occlusion pressures in humans. J Appl Physiol 1981;51:520-523.
11. De Troyer A. Differential control of the inspiratory intercostal muscles during airway occlusion in the dog. J Physiol 1991;439:73-88.
12. West JB. Control of ventilation. in: West JB, ed. Respiratory physiology - the essentials. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 1999;103-115.
13. Mitchell RA. Cerebrospinal fluid and the regulation of respiration. In: Caro CG, ed. Advances in respiratory physiology. London: Edward Arnold, 1966;1-47.
14. Leusen IR. Chemosensitivity of the respiratory center. Am J Physiol 1954;176:39-44.
15. Guyton AC, Hall JE. Behavioral and motivational mechanisms of the brain - the limbic system and the hypothalmus. In: Guyton AC, Hall JE, eds. Medical physiology. 10th ed. Philadelphia: WB Saunders Co, 2000;678-688.
16. Vainio O. Reversal of medetomidine-induced cardiovascular and respiratory changes with atipamezole in dogs. Vet Rec 1990;127:447-450.
17. Altose MD, Kelsen SG, Stanley NN, et al. Effects of hypercapnia on mouth pressure during airway occlusion in man. J Appl Physiol 1976;40:338-344.
18. Grunstein MM, Younes M, Milic-Emili J. Control of tidal volume and respiratory frequency in anesthetized cats. J Appl Physiol 1973;35:463-476.
19. Pengelly LD, Alderson AM, Milic-Emili J. Mechanics of the diaphragm. J Appl Physiol 1971;30:796-805.
20. Tranquilli WJ, Maze M. Clinical pharmacology and use of α2-adrenergic agonists in veterinary anaesthesia. Anaesth Pharmacol Rev 1993;1:297-309.