Toxic effects of mebendazole at high dose on the haematology of red-legged pademelons (Thylogale stigmatica)

Australian Veterinary Journal

Volumn 82, Issue 5, 2004, Pages 300-303

  Speare, R ^a   Skerratt, L F ^a   Berger, L ^a   Johnson, P M ^b  

^a JAMES COOK UNIVERSITY   (Australia)

^b DEPARTMENT OF ENVIRONMENT AND RESOURCE MANAGEMENT   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; ENTEROBACTERIACEAE; THYLOGALE; THYLOGALE STIGMATICA;

ANTINEMATODAL AGENT; MEBENDAZOLE;

AGRANULOCYTOSIS; ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; EVALUATION; LEUKOCYTE COUNT; MARSUPIAL; METABOLISM;

AGRANULOCYTOSIS; ANIMALS; ANTINEMATODAL AGENTS; LEUKOCYTE COUNT; MARSUPIALIA; MEBENDAZOLE;

EID: 3042619340     PISSN: 00050423     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-0813.2004.tb12710.x     Document Type: Article

References (18)

1. Speare R, Johnson P, Haffenden A. Management of disease in captive macropods in north Queensland. In: Evans D, editor. The Management of Australian Mammals in Captivity. The Zoological Board of Victoria, Melbourne, 1982:117-124.
2. Wroth O, MIMS Australia. 11th edn, MIMS Australia Business Group, St Leonards, 1999:624.
3. Marsboom R. Toxicologic studies on mebendazole. Toxicol Appl Pharmacol 1973;24:371-377.
4. Münst GJ, Karlaganis G, Bircher J. Plasma concentrations of mebendazole during treatment of echinococcosis. Preliminary results. Eur J Clin Pharmacol 1980;17:375-378.
5. Mravak S, Schoop W, Bienzle U. Treatment of strongyloidiasis with mebendazole. Acta Tropica 1983;40:93-94.
6. Fernandez-Banares F, Gonzalez-Huix F, Xiol X et al. Marrow aplasia during high dose mebendazole treatment. Am J Trop Med Hyg 1986;35:350-351.
7. Howard LH, Papendick R, Stalis IH et al. Benzimidazole toxicity in birds. Proceedings of the Am Assoc Zoo Vet 1999:36.
8. Papendick R, Stalis I, Harvey C et al. Suspected fenbendazole toxicity in birds. Proc Am Assoc Zoo Vet and Am Assoc Wildl Vet Joint Conference 1998:44-146.
9. Stokol T, Randolph JF, Nachbar S, Rodi C, Barr SC. Development of bone marrow toxicosis after albendazole administration in a dog and cat. J Am Vet Med Assoc 1997;210:1753-1756.
10. Johnson PM, Vernes K. Reproduction in the red-legged pademelon, Thylogale stigmatica Gould (Marsupialia: Macropodidae), and age estimation and development of pouch young. Wildl Res 1994;21:553-558.
11. Miskovitz PF, Javitt NB. Leukopenia associated with mebendazole therapy of hydatid disease. Am J Trop Med Hyg 1980;29:1356-1358.
12. Levin M, Weinstein R, Axelrod J, Schantz M. Severe reversible neutropenia during high-dose mebendazole therapy for echinococcosis. J Am Med Assoc 1983;249:2929-2931.
13. Braithwaite PA, Thomas RJ, Thompson RC. Hydatid disease: the alveolar variety in Australia. A case report with comment on the toxicity of mebendazole. Aust N Z J Surg 1985;55:519-523.
14. Braithwaite PA, Roberts MS, Allan RJ, Watson TR. Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease. Eur J Clin Pharmacol 1982;22:161-169.
15. Finch S. Neutrophil disorders - benign, quantitative abnormalities of neutrophils. In: William WJ et al, editors. Haematology. 3rd edn. McGraw-Hill, New York, 1983:773-792.
16. De Gruchy GC. Clinical Haematology in Medical Practice. 3rd edn. Blackwell Scientific Publications, London, 1972.
17. Sasaki J, Ramesh R, Chada S et al. The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Mol Cancer Ther 2002;13:1201-1209.
18. Blyde D. Advances in treating diseases of macropods. In: Wildlife in Australia: Healthcare and Management, Proceedings 327, Post Graduate Foundation in Veterinary Science, University of Sydney, 1999:439-452.