Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization

Infection and Immunity

Volumn 72, Issue 7, 2004, Pages 3803-3811

  Parameswaran, Neetha ^a   Samuvel, Devadoss John ^a,b   Kumar, Ramesh ^a,c   Thatai, Sangeeta ^a,d   Bal, Vineeta ^a   Rath, Satyajit ^a   George, Anna ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c TAN TOCK SENG HOSPITAL   (Singapore)

^d LabIndia   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; OVALBUMIN;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LYMPH NODE; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA; SEROTYPE; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TISSUE INDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS; IMMUNE TOLERANCE; IMMUNIZATION; INTERFERON TYPE II; LYMPHOID TISSUE; MICE; OVALBUMIN; T-LYMPHOCYTES;

EID: 3042599431     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.7.3803-3811.2004     Document Type: Article

References (42)

1. Berg, R. D., and D. C. Savage. 1975. Immune responses of specific-pathogen-free and gnotobiotic mice to antigens of indigenous and nonindigenous microorganisms. Infect. Immun. 11:320-329.
2. Blanas, E., F. R. Carbone, J. Allison, J. F. A. P. Miller, and W. R. Heath. 1996. Induction of autoimmune diabetes by oral administration of autoantigen. Science 274:1707-1709.
3. Bos, N. A., H.-Q. Jiang, and J. J. Cebra. 2001. T cell control of the gut IgA response against commensal bacteria. Gut 48:762-764.
4. Chung, Y., S. Y. Chang, and C. Y. Kang. 1999. Kinetic analysis of oral tolerance: memory lymphocytes are refractory to oral tolerance. J. Immunol. 163:3692-3698.
5. Duchmann, R., I. Kaiser, E. Hermann, W. Mayet, K. Ewe, and K. H. Meyer zum Buschenfelde. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102:448-455.
6. Duchmann, R., E. Schmitt, P. Knolle, K. H. Meyer zum Buschenfelde, and M. Neurath. 1996. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur. J. Immunol. 26:934-938.
7. Elson, C. O., and W. Ealding. 1984. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 133:2892-2897.
8. Faria, A. M., and H. L. Weiner. 1999. Oral tolerance: mechanisms and therapeutic applications. Adv. Immunol. 73:153-264.
9. Garg, S., V. Bal, S. Rath, and A. George. 1999. Effect of multiple antigenic exposures in the gut on oral tolerance and induction of antibacterial systemic immunity. Infect. Immun. 67:5917-5924.
10. George, A. 1996. Generation of gamma interferon responses in murine Peyer's patches following oral immunization. Infect. Immun. 64:4606-4611.
11. Gutgemann, I., A. M. Fahrer, J. D. Altman, M. M. Davis, and Y. H. Chien. 1998. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity 8:667-673.
12. Haskins, K., R. Kubo, J. White, M. Pigeon, J. Kappler, and P. Marrack. 1983. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157:1149-1169.
13. Hauet-Broere, F., W. W. Unger, J. Garssen, M. A. Hoijer, G. Kraal, and J. N. Samsom. 2003. Functional CD25- and CD25+ mucosal regulatory cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application. Eur. J. Immunol. 33:2801-2810.
14. Hoyne, G. F., and W. R. Thomas. 1995. T-cell responses to orally administered antigens. Study of the kinetics of lymphokine production after single and multiple feeding. Immunology 84:304-309.
15. Kagnoff, M. F. 1978. Effects of antigen-feeding on intestinal and systemic immune responses. II. Suppression of delayed type hypersensitivity reactions. J. Immunol. 120:1509-1513.
16. Karlsson, M. R., H. Kahu, L. A. Hanson, E. Telemo, and U. I. Dahlgren. 1999. Neonatal colonization of rats induces immunological tolerance to bacterial antigens. Eur. J. Immunol. 29:109-118.
17. Kearney, E. R., K. A. Pape, D. Y. Loh, and M. K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1:327-339.
18. Kraal, G., I. L. Weissman, and E. C. Butcher. 1983. Differences in in vivo distribution and homing of T cell subsets to mucosal vs nonmucosal lymphoid organs. J. Immunol. 130:1097-1102.
19. Kunkel, D., D. Kirchhoff, S. Nishikawa, A. Radbruch, and A. Scheffold. 2003. Visualization of peptide presentation following oral application of antigen in normal and Peyer's patches-deficient mice. Eur. J. Immunol. 33:1292-1301.
20. Lee, H. O., S. D. Miller, S. D. Hurst, L. J. Tan, C. J. Cooper, and T. A. Barrett. 2000. Interferon gamma induction during oral tolerance reduces T-cell migration to sites of inflammation. Gastroenterology 119:129-138.
21. MacDonald, T. T. 1998. T cell immunity to oral allergens. Curr. Opin. Immunol. 10:620-627.
22. Manohar, M., D. O. Baumann, N. A. Bos, and J. J. Cebra. 2001. Gut colonization of mice with actA-negative mutant of Listeria monocytogenes can stimulate a humoral mucosal immune response. Infect. Immun. 69:3542-3549.
23. Mattingly, J. A., and B. Waksman. 1978. Immunologic suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration. J. Immunol. 121:1878-1883.
24. Merica, R., A. Khoruts, K. A. Pape, R. L. Reinhardt, and M. K. Jenkins. 2000. Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. J. Immunol. 164:4551-4557.
25. Miller, M. L., J. S. Cowdery, C. A. Laskin, M. F. Cutrin, Jr., and A. D. Steinberg. 1984. Heterogeneity of oral tolerance defects in autoimmune mice. Clin. Immunol. Immunopathol. 31:231-240.
26. Moore, M. W., F. R. Carbone, and M. J. Bevan. 1988. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54:777-785.
27. Mowat, A. M. 2003. Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev. Immunol. 3:331-341.
28. Nakagawa, T. Y., H. Von Grafenstein, J. E. Sears, J. Williams, C. A. Janeway, and R. A. Flavell. 1991. The use of the polymerase chain reaction to map CD4+ T cell epitopes. Eur. J. Immunol. 21:2851-2855.
29. Read, S., and F. Powrie. 2001. CD4+ regulatory T cells. Curr. Opin. Immunol. 13:644-649.
30. Robertson, J. M., P. E. Jensen, and B. D. Evavold. 2000. DO11.10 and OT-11 T cells recognize a C-terminal ovalbumin 323-339 epitope. J. Immunol. 164:4706-4712.
31. Shroff, K. E., K. Meslin, and J. J. Cebra. 1995. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63:3904-3913.
32. Simon, G. L., and S. L. Gorbach. 1984. Intestinal flora in health and disease. Gastroenterology 86:174-193.
33. Singh, N., S. Bhatia, R. Abraham, S. K. Basu, A. George, V. Bal, and S. Rath. 1998. Modulation of T cell cytokine profiles and peptide-MHC complex availability in vivo by delivery to scavenger receptors via antigen maleylation. J. Immunol. 160:4869-4880.
34. Smith, K. M., J. M. Davidson, and P. Garside. 2002. T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division. Immunology 106:144-158.
35. Strobel, S., and A. M. Mowat. 1998. Immune responses to dietary antigens: oral tolerance. Immunol. Today 19:173-181.
36. Talham, G. L., H.-Q. Jiang, N. A. Bos, and J. J. Cebra. 1999. Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infect. Immun. 67:1992-2000.
37. Thatte, J., S. Rath, and V. Bal. 1993. Immunization with live versus killed Salmonella typhimurium leads to the generation of an IFN-gamma dominant versus an IL-4 dominant immune response. Int. Immunol. 5:1431-1436.
38. Thorstenson, K. M., and A. Khoruts. 2001. Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167:188-195.
39. Van Houten, N., and S. F. Blake. 1996. Direct measurement of anergy of antigen-specific T cells following oral tolerance induction. J. Immunol. 157: 1337-1341.
40. Vidard, L., L. J. Colarusso, and B. Benacerraf. 1994. Specific T-cell tolerance may be preceded by a primary response. Proc. Natl. Acad. Sci. USA 91:5627-5631.
41. Wannemuehler, M. J., H. Kiyono, J. L. Babb, S. M. Michalek, and J. R. McGhee. 1982. Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction. J. Immunol. 129:959-965.
42. Williamson, E., J. M. O'Malley, and J. L. Viney. 1999. Visualizing the T-cell response elicited by oral administration of soluble protein antigen. Immunology 97:565-572.