Characteristics of testicular lesions in mice infected with a low dose of encephalomyocarditis (EMC) virus

Experimental and Molecular Pathology

Volumn 77, Issue 1, 2004, Pages 72-76

  Yamanouchi Ueno, Aito ^a   Nakayama, Yumi ^a   Doi, Kunio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

EMC virus; Low dose inoculation; Macrophage; Testicular lesion

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENCEPHALOMYOCARDITIS VIRUS; EXPERIMENTAL MODEL; GERM LAYER; INOCULATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERTOLI CELL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TESTIS INJURY; VIRUS DETECTION; VIRUS INFECTION; VIRUS TITRATION;

ANIMALS; CARDIOVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENCEPHALOMYOCARDITIS VIRUS; IN SITU HYBRIDIZATION; INTERFERON TYPE II; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; ORCHITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; TESTIS;

ENCEPHALOMYOCARDITIS VIRUS;

EID: 3042598673     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexmp.2003.12.008     Document Type: Article

References (29)

1. Bae Y.S., Eun H.M., Yoon J.W. Genetic difference between the diabetogenic and non-diabetogenic variants of encephalomyocarditis virus. Virology. 170:1989;282-287
2. Baek H-S., Yoon J.W. Direct involvement of macrophages in destruction of β-cells leading to development of diabetes in virus-infected mice. Diabetes. 40:1991;1586-1597
3. Doi K., Onodera T., Tsuda T., Matsuzaki H., Mitsuoka T. Histopathology of BALB/c mice infected with the D variant of encephalomyocarditis virus. Br. J. Exp. Pathol. 69:1988;395-401
4. Doi K., Ikegami H., Ishii K., Doi C., Yamanouchi J., Sugano S. Encephalomyocarditis (EMC) virus infection in the common vole, Microtus arvalis. Lab. Anim. 29:1995;180-184
5. Eun H.M., Bae Y.S., Yoon J.W. Amino acid difference in capsid protein, VP1, between diabetogenic and non-diabetogenic variants of encephalomyocarditis virus. Virology. 163:1988;369-373
6. Fazakerley J.K., Southern P., Bloom F., Buchmeier M.J. High resolution in situ hybridization of lymphocytic choriomeningitis virus RNA in tissues of persistently infected mice. Science. 102:1991;31-33
7. Han H.S., Jun H.S., Utsugi T., Yoon J.W. A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice. J. Autoimmun. 9:1996;331-339
8. Hirasawa K., Takeda M., Matsuzaki H., Doi K. Encephalomyocarditis (EMC) virus-induced orchitis in Syrian hamsters. Int. J. Exp. Pathol. 72:1991;617-622
9. Hirasawa K., Han J.S., Takeda M., Itagaki S., Doi K. Encephalomyocarditis (EMC) virus-induced myocarditis by different virus variants and mouse strains. J. Vet. Med. Sci. 54:1992;1125-1129
10. Hirasawa K., Tsutsui S., Takeda M., Mizutani S., Itagaki S., Doi K. Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes. J. Gen. Virol. 77:1996;737-741
11. Hirasawa K., Jun H.S., Maeda K., Kawaguchi Y., Itagaki S., Mikami T., Baek H.S., Doi K., Yoon J.W. Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J. Virol. 71:1997;4024-4031
12. Holyoak G.R., Giles R.C., Mc Collum W.H., Little T.V., Timoney P.J. Pathological changes associated with equine arteritis virus RNA in the infection of reproductive tract in prepubert and peripubert. J. Comp. Pathol. 109:1993;281-293
13. Ikegami H., Takeda M., Doi K. An age-related changes in susceptibility of rat brain to encephalomyocarditis (EMC) virus infection. Int. J. Exp. Pathol. 78:1997;101-107
14. Matsuzaki H., Doi K., Doi C., Onodera T., Mitsuoka T. Susceptibility of four species of small rodents to encephalomyocarditis (EMC) virus infection. Exp. Anim. 38:1989;357-361
15. Matsuzaki H., Doi K., Mitsuoka T., Tsuda T., Onodera T. Experimental encephalomyocarditis virus infection in Mongolian gerbils (Meriones unguiculatus). Vet. Pathol. 26:1989;11-17
16. McDaniel M.L., Kwon G., Hill J.R., Marshall C.A., Corbet J.A. Cytokines and nitric oxide in islet inflammation and diabetes. Proc. Soc. Exp. Biol. Med. 211:1996;24-32
17. Mostofi F.K., Davis C.J. Male reproductive system and prostate. Kissane J.M. Anderson's Pathology. 1990;871-919 CV Mosby, St. Louis, MO
18. Muir A., Peck A., Clare-Salzler M., Song Y.-H., Cornelius J., Luchetta R., Krischer J., Maclaren N. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J. Clin. Invest. 95:1995;628-634
19. Petruccelli M.A., Hirasawa K., Takeda M., Itagaki S., Doi K. Cardiac and pancreatic lesions in guinea-pigs infected with encephalomyocarditis (EMC) virus. Histol. Histopathol. 6:1991;167-170
20. Pudney J., Anderson D. Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome. Am. J. Pathol. 139:1991;149-160
21. Shigesato M., Hirasawa K., Takeda M., Doi K. Encephalomyocarditis (EMC) virus-induced testicular lesion in BALB/c mice. Lab. Anim. 28:1994;330-334
22. Shigesato M., Takeda M., Hirasawa K., Itagaki S., Doi K. Early development of encephalomyocarditis virus-induced orchitis in Syrian hamsters. Vet. Pathol. 32:1995;184-186
23. Sugawara Y., Hirasawa K., Takeda M., Han J.S., Doi K. Acute infection of encephalomyocarditis (EMC) virus in Syrian hamsters. J. Vet. Med. Sci. 53:1991;463-468
24. Takeda M., Itagaki S., Doi K. Biphasic disease of central nervous system induced in DBA/2 mice by the D variant of encephalomyocarditis virus (EMC-D). Int. J. Exp. Pathol. 74:1993;493-499
25. Takeda M., Miura R., Shiota K., Hirasawa K., Lee M.J., Itagaki S., Doi K. Distribution of viral RNA in spinal cord of DBA/2 mice developing biphasic paralysis following infection with the D variant of encephalomyocarditis virus (EMC-D). Int. J. Exp. Pathol. 76:1995;441-447
26. Ueno A., Takeda M., Hirasawa K., Itagaki S., Doi K. Relationship between distribution of viral RNA and development of histopathological changes in encephalomyocarditis virus-induced orchitis in mice. Int. J. Exp. Pathol. 77:1996;25-30
27. Ueno A., Takeda M., Hirasawa K., Itagaki S., Doi K. Detection of viral RNA by electron microscopic in situ hybridization (ISH-EM) in the germinal epithelium of mice infected with encephalomyocarditis (EMC) virus. Exp. Anim. 46:1997;79-81
28. Yama S., Nishioka W., Hirokami Y., Setoguchi R., Takeyama N., Saeki K., Matsumoto Y., Hayashi T., Doi K., Onodera T. Effects of tacrolimus (FK506) on encephalomyocarditis virus-induced diabetes in mice. Microbiol. Immunol. 48:2004;7-13
29. Yoon J.W., McClintock P.R., Bachurski C.J., Longstreth J.D., Notkins A.L. Virus-induced diabetes mellitus: no evidence for immune mechanisms in the destruction of β-cells by the D variant of encephalomyocarditis virus. Diabetes. 34:1985;922-925