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Volumn 43, Issue 11, 2003, Pages 909-911

Development of therapeutics for spinal and bulbar muscular atrophy (SBMA)

Author keywords

Heat shock protein (HSP); Polyglutamine; Spinal and bulbar muscular atrophy (SBMA); Testosterone; Transgenic mouse

Indexed keywords

ANDROGEN RECEPTOR; CHAPERONE; GONADORELIN AGONIST; HEAT SHOCK PROTEIN 70; LEUPRORELIN; MUTANT PROTEIN; POLYGLUTAMINE; PROTEASOME; TESTOSTERONE; UBIQUITIN;

EID: 3042588809     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (4)

References (10)
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  • 4
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    • Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy
    • Li M, Miwa S, Kobayashi Y, et al: Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy. Ann. Neurol. 1998a; 44: 249-254
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  • 5
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    • Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
    • Katsuno M, Adachi H, Kume A, et al: Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron 2002; 35: 843-854
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    • Katsuno, M.1    Adachi, H.2    Kume, A.3
  • 6
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    • Schmidt BJ, Greenberg CR, Allingham-Hawkins DJ, et al: Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women. Neurology 2002; 59: 770-772
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    • Schmidt, B.J.1    Greenberg, C.R.2    Allingham-Hawkins, D.J.3
  • 7
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    • Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy
    • Katsuno M, Adachi H, Doyu M, et al: Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat Med 2003; 9: 768-773
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    • Katsuno, M.1    Adachi, H.2    Doyu, M.3
  • 8
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    • Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract
    • Kobayashi Y, Kume A, Li M, et al: Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 2000; 275: 8772-8778
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  • 9
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    • Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein
    • Adachi H, Katsuno M, Minamiyama M, et al: Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci 2003; 23: 2203-2211
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.