Desensitization of P2X2 receptor/channel pore mutants

European Journal of Pharmacology

Volumn 495, Issue 1, 2004, Pages 27-33

  Nakazawa, Ken ^a   Ohno, Yasuo ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

ATP responsiveness; Channel pore mutant; Desensitization; P2X2 receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; PURINE P2X2 RECEPTOR; LIGAND; PURINE P2 RECEPTOR;

ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; ION CURRENT; MUTANT; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; ANIMAL; CELL MEMBRANE POTENTIAL; DESENSITIZATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; IMMUNOLOGY; METABOLISM; MUTATION; OOCYTE; PHYSIOLOGY; TIME; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; DESENSITIZATION, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ION CHANNEL GATING; LIGANDS; MEMBRANE POTENTIALS; MUTATION; OOCYTES; RECEPTORS, PURINERGIC P2; TIME FACTORS; XENOPUS LAEVIS;

EID: 3042575118     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.05.021     Document Type: Article

References (18)

1. 2 receptors identified by the substituted cysteine accessibility method. J. Neurosci. 18:1998;2350-2359
2. 1 receptors. J. Biol. Chem. 275:2000;29361-29367
3. Hille B. Classical biophysics of the squid giant axon. Ionic Channels of Excitable Membranes. second edition:1992;23-58 Sinauer, Sunderland, MA
4. Hille B. Ligand-gated channels of fast chemical synapses. Ionic Channels of Excitable Membranes. second edition:1992;140-169 Sinauer, Sunderland, MA
5. Hodgkin A.L., Huxley A.F. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J. Physiol. 116:1952;497-506
6. Jiang L.H., Rassendren F., Surprenant A., North R.A. Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor. J. Biol. Chem. 275:2000;34190-34196
7. Katz B., Thesleff S. A study of the "desensitization" produced by acetylcholine at the motor end-plate. J. Physiol. 138:1957;63-80
8. Khakh B.S. Molecular physiology of P2X receptors and ATP signalling at synapses. Nat. Rev. 2:2001;165-174
9. 2-green fluorescent protein receptors. Proc. Natl. Acad. Sci. U. S. A. 98:2001;5288-5293
10. Li G.-H., Lee E.M., Blair D., Holding C., Poronnik P., Cook D.I., Barden J.A., Bennett M.R. The distribution of P2X receptor clusters on individual neurons in sympathetic ganglia and their redistribution on agonist activation. J. Biol. Chem. 275:2000;29107-29112
11. Nakazawa K., Ohno Y. Dopamine and 5-hydroxytryptamine selectively potentiate neuronal type ATP receptor channels. Eur. J. Pharmacol. 296:1996;119-122
12. Nakazawa K., Ohno Y., Inoue K. An aspartic acid residue near the second transmembrane segment of ATP receptor/channel regulates agonist sensitivity. Biochem. Biophys. Res. Commun. 244:1998;599-603
13. 2 receptor. Eur. J. Pharmacol. 449:2002;207-211
14. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 82:2002;1013-1067
15. Ralevic V., Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:1998;413-492
16. Rassendren F., Buell G., Newbolt A., North R.A., Surprenant A. Identification of amino acid residues contributing to the pore of a P2X receptor. EMBO J. 16:1997;3446-3454
17. Tallarida R.J., Jacob L.S. Kinetics of drug-receptor interaction: interpreting dose-response data. Dose-response relation in Pharmacology. 1979;49-84 Springer, New York, NY
18. Werner P., Seward E.P., Buell G.N., North R.A. Domains of P2X receptors involved in desensitization. Proc. Natl. Acad. Sci. U. S. A. 93:1996;15485-15490