Chlorotoxin-mediated disinhibition of noradrenergic locus coeruleus neurons using a conditional transgenic approach

Brain Research

Volumn 1016, Issue 1, 2004, Pages 20-32

  Salbaum, J Michael ^a,b   Cirelli, Chiara ^a,c   Walcott, Elisabeth ^a   Krushel, Les A ^a,d   Edelman, Gerald M ^a   Tononi, Giulio ^a,b  

^a NEUROSCIENCES INSTITUTE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Chlorotoxin; Conditional transgene; Cre mediated recombination; Locus coeruleus; NGFI A; Norepinephrine

Indexed keywords

CHLORIDE CHANNEL; CHLOROTOXIN; EARLY GROWTH RESPONSE FACTOR 1; GLYCINE; SCORPION VENOM; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EXCITATION; FEMALE; GABAERGIC SYSTEM; IMMEDIATE EARLY GENE; LOCUS CERULEUS; MALE; MOUSE; NONHUMAN; NORADRENERGIC NERVE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSGENICS;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; CHLORIDES; EMBRYO; FIBROBLASTS; FLUORESCENT DYES; GAMMA-AMINOBUTYRIC ACID; GENES, REPORTER; IMMUNOHISTOCHEMISTRY; INTEGRASES; LOCUS COERULEUS; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; NEURAL INHIBITION; NEURONS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PATCH-CLAMP TECHNIQUES; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCORPION VENOMS; STILBAMIDINES; SYMPORTERS; SYNAPSES; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

EID: 3042559658     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.03.078     Document Type: Article

References (64)

1. Ahearn J.M., Bartolomei M.S. Jr., West M.L., Cisek L.J., Corden J.L. Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II. J. Biol. Chem. 262:1987;10695-10705
2. Aston-Jones G., Bloom F.E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J. Neurosci. 1:1981;876-886
3. Aston-Jones G., Shipley M.T., Chouvet G., Ennis M., van Bockstaele E., Pieribone V., Shiekhattar R., Akaoka H., Drolet G., Astier B., et al. Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Prog. Brain Res. 88:1991;47-75
4. Aston-Jones G., Rajkowski J., Kubiak P., Alexinsky T. Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task. J. Neurosci. 14:1994;4467-4480
5. Aston-Jones G., Rajkowski J., Kubiak P. Conditioned responses of monkey locus coeruleus neurons anticipate acquisition of discriminative behavior in a vigilance task. Neuroscience. 80:1997;697-715
6. Aston-Jones G., Chen S., Zhu Y., Oshinsky M.L. A neural circuit for circadian regulation of arousal. Nat. Neurosci. 4:2001;732-738
7. Barnes C.D., Pompeiano O. Neurobiology of the Locus Coeruleus. Progress in Brain Research. vol. 88:1991;Elsevier, Amsterdam
8. Basheer R., Magner M., McCarley R.W., Shiromani P.J. REM sleep deprivation increases the levels of tyrosine hydroxylase and norepinephrine transporter mRNA in the locus coeruleus. Mol. Brain Res. 57:1998;235-240
9. Baubonis W., Sauer B. Genomic targeting with purified Cre recombinase. Nucleic Acids Res. 21:1993;2025-2029
10. Ben-Ari Y. Cell death and synaptic reorganizations produced by seizures. Epilepsia. 42(Suppl 3):2001;5-7
11. Berridge C.W., Foote S.L. Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. J. Neurosci. 11:1991;3135-3145
12. Brocard J., Feil R., Chambon P., Metzger D. A chimeric Cre recombinase inducible by synthetic but not by natural ligands of the glucocorticoid receptor. Nucleic Acids Res. 26:1998;4086-4090
13. Chang M.S., Sved A.F., Zigmond M.J., Austin M.C. Increased transcription of the tyrosine hydroxylase gene in individual locus coeruleus neurons following footshock stress. Neuroscience. 101:2000;131-139
14. Cherubini E., North R.A., Williams J.T. Synaptic potentials in rat locus coeruleus neurones. J. Physiol. 406:1988;431-442
15. Cirelli C., Tononi G. Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system. J. Neurosci. 20:2000;9187-9194
16. Cirelli C., Pompeiano M., Tononi G. Neuronal gene expression in the waking state: a role for the locus coeruleus. Science. 274:1996;1211-1215
17. Darracq L., Gervasoni D., Souliere F., Lin J.S., Fort P., Chouvet G., Luppi P.H. Effect of strychnine on rat locus coeruleus neurones during sleep and wakefulness. NeuroReport. 8:1996;:351-355
18. DeBin J.A., Strichartz G.R. Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus. Toxicon. 29:1991;1403-1408
19. DeBin J.A., Maggio J.E., Strichartz G.R. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am. J. Physiol. 264:1993;C361-C369
20. Edwards F.A., Konnerth A., Sakmann B., Takahashi T. A thin slice preparation for patch clamp recordings from neurons of the mammalian central nervous system. Pflugers Arch. 414:1989;600-612
21. Ennis M., Aston-Jones G. GABA-mediated inhibition of locus coeruleus from the dorsomedial rostral medulla. J. Neurosci. 9:1989;2973-2981
22. Franklin K.B.J., Paxinos G. The Mouse Brain in Stereotaxic Coordinates. 1997;Academic Press, San Diego, CA
23. Gervasoni D., Darracq L., Fort P., Souliere F., Chouvet G., Luppi P.H. Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep. Eur. J. Neurosci. 10:1998;964-970
24. Hogan B., Beddington R., Costantini F., Lacy E. Manipulating the Mouse Embryo: A Laboratory Manual. 1994;Cold Spring Harbor Laboratory Press, Plainview, New York
25. Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4:1998;97-100
26. Hoyle G.W., Mercer E.H., Palmiter R.D., Brinster R.L. Cell-specific expression from the human dopamine beta-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements. J. Neurosci. 14:1994;2455-2463
27. Hwang D.Y., Carlezon W.A. Jr., Isacson O., Kim K.S. A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Hum. Gene Ther. 12:2001;1731-1740
28. Kaspar B.K., Vissel B., Bengoechea T., Crone S., Randolph-Moore L., Muller R., Brandon E.P., Schaffer D., Verma I.M., Lee K.F., Heinemann S.F., Gage F.H. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc. Natl. Acad. Sci. U. S. A. 99:2002;2320-2325
29. Kellendonk C., Tronche F., Casanova E., Anlag K., Opherk C., Schutz G. Inducible site-specific recombination in the brain. J. Mol. Biol. 285:1999;175-182
30. Klimek V., Stockmeier C., Overholser J., Meltzer H.Y., Kalka S., Dilley G., Ordway G.A. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J. Neurosci. 17:1997;8451-8458
31. Le Gal La Salle G., Robert J.J., Berrard S., Ridoux V., Stratford-Perricaudet L.D., Perricaudet M., Mallet J. An adenovirus vector for gene transfer into neurons and glia in the brain. Science. 259:1993;988-990
32. Lewandoski M. Conditional control of gene expression in the mouse. Nat. Rev., Genet. 2:2001;743-755
33. Maertens C., Wei L., Tytgat J., Droogmans G., Nilius B. Chlorotoxin does not inhibit volume-regulated, calcium-activated and cyclic AMP-activated chloride channels. Br. J. Pharmacol. 129:2000;791-801
34. Malleret G., Haditsch U., Genoux D., Jones M.W., Bliss T.V., Vanhoose A.M., Weitlauf C., Kandel E.R., Winder D.G., Mansuy I.M. Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell. 104:2001;675-686
35. Mataga N., Fujishima S., Condie B.G., Hensch T.K. Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J. Neurosci. 21:2001;9724-9732
36. Mayford M., Bach M.E., Huang Y.Y., Wang L., Hawkins R.D., Kandel E.R. Control of memory formation through regulated expression of a CaMKII transgene. Science. 274:1996;1678-1683
37. McHugh T.J., Blum K.I., Tsien J.Z., Tonegawa S., Wilson M.A. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell. 87:1996;1339-1349
38. Mercer E.H., Hoyle G.W., Kapur R.P., Brinster R.L., Palmiter R.D. The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron. 7:1991;703-716
39. Osmanovic S.S., Shefner S.A. Gamma-aminobutyric acid responses in rat locus coeruleus neurones in vitro: a current-clamp and voltage-clamp study. J. Physiol. 421:1990;151-170
40. Porkka-Heiskanen T., Smith S.E., Taira T., Urban J.H., Levine J.E., Turek F.W., Stenberg D. Noradrenergic activity in rat brain during rapid eye movement sleep deprivation and rebound sleep. Am. J. Physiol. 268:1995;R1456-R1463
41. Rinaldi A., Marshall K.R., Preston C.M. A non-cytotoxic herpes simplex virus vector which expresses Cre recombinase directs efficient site specific recombination. Virus Res. 65:1999;11-20
42. Robbins T.W., Everitt B.J. Central norepinephrine neurons and behavior. Bloom F.E., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1995;363-372 Raven Press, New York
43. Sara S.J., Devauges V. Priming stimulation of locus coeruleus facilitates memory retrieval in the rat. Brain Res. 438:1988;299-303
44. Sauer B. Inducible gene targeting in mice using the Cre/lox system. Methods. 14:1998;381-392
45. Schmued L.C., Albertson C., Slikker W. Jr. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 751:1997;37-46
46. Shishido T., Watanabe Y., Matsuoka I., Nakanishi H., Niwa S. Acute methamphetamine administration increases tyrosine hydroxylase mRNA levels in the rat locus coeruleus. Mol. Brain Res. 52:1997;146-150
47. Smith A., Nutt D. Noradrenaline and attention lapses. Nature. 380:1996;291
48. Somogyi J., Llewellyn-Smith I.J. Patterns of colocalization of GABA, glutamate and glycine immunoreactivities in terminals that synapse on dendrites of noradrenergic neurons in rat locus coeruleus. Eur. J. Neurosci. 14:2001;219-228
49. + ion channel blockers. J. Neurosci. 19:1999;5942-5954
50. Szot P., Ashliegh E.A., Kohen R., Petrie E., Dorsa D.M., Veith R. Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment. Brain Res. 618:1993;308-312
51. Treiman D.M. GABAergic mechanisms in epilepsy. Epilepsia. 42(Suppl. 3):2001;8-12
52. Tsien J.Z., Chen D.F., Gerber D., Tom C., Mercer E.H., Anderson D.J., Mayford M., Kandel E.R., Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell. 87:1996;1317-1326
53. Tsien J.Z., Huerta P.T., Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 87:1996;1327-1338
54. Ullrich N., Sontheimer H. Biophysical and pharmacological characterization of chloride currents in human astrocytoma cells. Am. J. Physiol. 270:1996;C1511-C1521
55. Ullrich N., Gillespie G.Y., Sontheimer H. Human astrocytoma cells express a unique chloride current. NeuroReport. 7:1995;343-347
56. Usher M., Cohen J.D., Servan-Schreiber D., Rajkowski J., Aston-Jones G. The role of locus coeruleus in the regulation of cognitive performance. Science. 283:1999;549-554
57. Velley L., Cardo B., Kempf E., Mormede P., Nassif-Caudarella S., Velly J. Facilitation of learning consecutive to electrical stimulation of the locus coeruleus: cognitive alteration or stress-reduction? Prog. Brain Res. 88:1991;555-569
58. Walcott E.C., Langdon R.B. Short-term plasticity of extrinsic excitatory inputs to neocortical layer 1. Exp. Brain Res. 136:2001;143-151
59. Wang Y., Krushel L.A., Edelman G.M. Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. Proc. Natl. Acad. Sci. U. S. A. 93:1996;3932-3936
60. Wells T., Carter D.A. Genetic engineering of neural function in transgenic rodents: towards a comprehensive strategy? J. Neurosci. Methods. 108:2001;111-130
61. White B.H., Osterwalder T.P., Yoon K.S., Joiner W.J., Whim M.D., Kaczmarek L.K., Keshishian H. Targeted attenuation of electrical activity in Drosophila using a genetically modified K(+) channel. Neuron. 31:2001;699-711
62. Williams J.T., North R.A., Shefner S.A., Nishi S., Egan T.M. Membrane properties of rat locus coeruleus neurones. Neuroscience. 13:1984;137-156
63. Xiao Q., Yao Y., Tejani-Butt S.M. Acute administration of alpha-methyl-para-tyrosine alters levels of norepinephrine transporter mRNA in the rat brainstem. Mol. Brain Res. 30:1995;389-392
64. Yang H., Raizada M.K. Regulation of neuromodulatory actions of angiotensin II in the brain neurons by the Ras-dependent mitogen-activated protein kinase pathway. J. Neurosci. 16:1996;4047-4058