Age-associated decreased activities of mitochondrial electron transport chain complexes in heart and skeletal muscle: Role of L-carnitine

Chemico-Biological Interactions

Volumn 148, Issue 1-2, 2004, Pages 11-18

  Kumaran, Sundaram ^a   Subathra, Marimuthu ^a   Balu, Muthiyah ^a   Panneerselvam, Chinnakkannu ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Aging; Carnitine; Electron transport chain; Mitochondria

Indexed keywords

CARNITINE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; HEART MUSCLE; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; RAT; RESPIRATORY CHAIN; SKELETAL MUSCLE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

AGING; ANIMALS; CARNITINE; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; FEMALE; FREE RADICAL SCAVENGERS; HEART; MITOCHONDRIA, HEART; MUSCLE, SKELETAL; RATS; RATS, WISTAR;

EID: 3042558060     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2003.10.010     Document Type: Article

References (33)

1. Beal M.F. Mitochondria and pathogenesis of ALS. Brain. 123:2000;1291-1292
2. Kwong L.K., Shoal R.S. Age-related changes in activities of mitochondrial electron transport complexes in various tissues of mouse. Arch. Biochem. Biophys. 373:2000;16-22
3. Liu J., et al. Immobilization stress causes oxidative damage to lipid, protein and DNA in the brain of rats. FASEB J. 10:1996;1532-1538
4. Cortopassi G.A., Shibata D., Soong N.W., Arnheim N. A pattern of accumulation of somatic deletion of mitochondrial DNA in aging tissue. Proc. Natl. Acad. Sci. 89:1992;7370-7374
5. Ozawa T. Genetic and functional changes in mitochondria associated with aging. Physiol. Rev. 77:1997;425-464
6. Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases. Sciences. 61:1992;1175-1212
7. Rebouche C.J. Carnitine function and requirements during the life cycle. FASEB J. 6:1992;3379-3386
8. Iossa S., Mollica M.P., Lionetti L., Crescenzo R., Botta M., Barletta A. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. J. Nutr. 132:2002;636-642
9. Taglialatela G., Navarra D., Cruciani R., Ramacci M.T., Alema G.S. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp. Gerontol. 29:1994;55-66
10. Hagen T.M., Moreau R., Suh J.H., Visioli F. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Ann. N. Y. Acad. Sci. 959:2002;491-507
11. Takasawa M., Hayakawa M., Sugiyama S., Hattori K., Ito T., Ozawa T. Age associated damage in heart mitochondrial function in rat heart. Exp. Gerontol. 28:1993;269-280
12. Ernster L., Nordenbrand K. Skeletal muscle mitochondria. Methods Enzymol. 10:1967;86-94
13. Slater E.C., Bonner W.D. Effect of fluride on succinate oxidase system. Biochem. J. 52:1952;185-196
14. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1193:1951;265-275
15. M. Brich-Machin, S. Jacson, R.S. Kler, D.M. Turnbull, in: L.H. Lash, D.P Jones (Eds.), Mitochondrial Dysfunction, Academic Press, San Diego, CA, 1993, pp. 51-69.
16. C.I. Ragan, M.T. Wilson, V.M. Darley-Usmar, P.N. Lowe, in: V.M. Darley-Usmar, D. Richwood, M.T. Wilson (Eds.), Mitochondria: a Practical Approach, IRC Press, Oxford, 1987, pp. 79-112.
17. Wharton D.C., Tzagoloff A. Cytochrome oxidase from beef heart mitochondria. Methods Enzymol. 10:1967;245-250
18. Lenaz G. Role of mitochondria in oxidative stress and aging. Biochem. Biophys. Acta. 1336:1998;53-67
19. Filburn C.R., Edris W., Tamatani M., Hogue B., Kudryashova I., Hansford R.D. Mitochondrial electron transport chain activities and DNA deletions in regions of rat brain. Mech. Aging Dev. 87:1996;35-46
20. Hsieh R.H., Hou J.H., Hsu H.S., Wei Y.H. Age dependent respiratory function and mitochondrial DNA deletion in human skeletal muscle mitochondria. Biochem. Mol. Biol. Int. 32:1994;1009-1022
21. Melov S., Coskun P.E., Wallace D.C. Mouse models of mitochondrial disease, oxidative stress and senescence. Mutat. Res. 434:1999;233-242
22. Schware S.R., Lee C.M., Chung S.S., Roecker E.B., Weindruch R., Aiken M. High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkey. Mech. Aging Dev. 83:1995;91-101
23. S. Papa, N. Capitanio, G. Villani, in: S. Papa, F. Guerrieri, J. Tager (Eds.), Frontiers of Cellular Bioenergetics. Molecular Biology, Biochemistry and Physiopathology, Kluwer Academic/Plenum Press, New York, 2002.
24. Singh R.J. Glutathione: a marker and antioxidant for aging. J. Lab. Clin. Med. 140:2002;380-381
25. Vijg J. Genetics of aging. Biochim. Biophys. Acta. 1423:1999;R 1-R 12
26. Barja G. The flux of free radical attack through mitochondrial DNA is related to aging. Aging. 12:2000;342-355
27. Sandhu S.K., Kaur G. Mitochondrial electron transport chain complexes in aging rat brain and lymphocytes. Biogerontology. 4:2003;19-29
28. Drouet M., Lauthier F., Charmes J.P., Sauvage P., Ratinand M.H. Age associated changes in mitochondrial parameters on peripheral human lymphocytes. Exp. Gerontol. 34:1999;69-78
29. Wallace D.C. Mitochondria diseases in man and mouse. Science. 283:1999;1482-1488
30. Rani P.J., Panneerselvam C. Carnitine as a free radical scavenger in aging. Exp. Gerontol. 36:2001;1713-1726
31. Benzi G., Pastoris O., Marzatico R.F., Villa R.F., Curti D. The mitochondrial electron transfer alteration as a factor involved in the brain aging. Neurobiol. Aging. 13:1992;361-368
32. Sohal R.S. Aging, cytochrome oxidase activity and hydrogen peroxide release by mitochondria. Free Radic. Biol. Med. 14:1993;583-588
33. Paradies G., Ruggiero F.M., Petrosillo G., Quagliariello E. Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin. FEBS Lett. 406:1997;136-138