Does excessive occlusal load affect osseointegration? An experimental study in the dog

Clinical Oral Implants Research

Volumn 15, Issue 3, 2004, Pages 259-268

  Heitz Mayfield, L J ^a   Schmid, B ^a   Weigel, C ^a   Gerber, S ^a   Bosshardt, D D ^a   Jonsson J ^b   Lang, N P ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b MALMÖ UNIVERSITY   (Sweden)

Author keywords

Bone loss; Histology; Marginal bone level; Occlusal load; Osseointegration; Titanium implants

Indexed keywords

GOLD; TITANIUM; BIOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; BONE REGENERATION; CLINICAL EXAMINATION; COMPARATIVE STUDY; CONTROLLED STUDY; DENTAL ACID ETCHING; DOG; HEALING; HISTOLOGY; IMPLANT; MANDIBLE; MEASUREMENT; MECHANICAL STRESS; MEDICAL PARAMETERS; MOLAR TOOTH; MOUTH MUCOSA; NONHUMAN; NONPARAMETRIC TEST; OSTEOLYSIS; PREMOLAR TOOTH; STATISTICAL SIGNIFICANCE; TOOTH CROWN; TOOTH EXTRACTION; TOOTH IMPLANTATION; TOOTH PLAQUE; TOOTH PROSTHESIS; TOOTH RADIOGRAPHY; ANIMAL; ANIMAL MODEL; DENTAL SURGERY; JAW; MASTICATION; PATHOLOGY; PATHOPHYSIOLOGY; PERIODONTITIS; PHYSIOLOGY; RADIOGRAPHY; TIME; WOUND HEALING;

ACID ETCHING, DENTAL; AIR ABRASION, DENTAL; ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ANIMALS; BITE FORCE; COATED MATERIALS, BIOCOMPATIBLE; CROWNS; DENTAL IMPLANTS; DENTAL PROSTHESIS DESIGN; DENTAL PROSTHESIS, IMPLANT-SUPPORTED; DOGS; MANDIBLE; MODELS, ANIMAL; OSSEOINTEGRATION; PERIODONTAL POCKET; TIME FACTORS; TITANIUM; WOUND HEALING;

EID: 3042524214     PISSN: 09057161     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2004.01019.x     Document Type: Article

References (78)

1. Adell, R., Lekholm, U., Rockler, B., Brånemark, P.I., Lindhe, J., Eriksson, B. & Sbordone, L. (1986) Marginal tissue reactions at osseointegrated titanium fixtures. International Journal of Oral and Maxillofacial Surgery 15: 39-52.
2. Akin-Nergiz, N., Nergiz, I., Schulz, A., Arpak, N. & Niedermeier, W. (1998) Reactions of peri-implant tissues to continuous loading of osseointegrated implants. American Journal of Orthodontics and Dentofacial Orthopedics 114: 292-298.
3. Alcoforado, G.A., Rams, T.E., Feik, D. & Slots, J. (1991) Microbial aspects of failing osseointegrated dental implants in humans. Journal de Parodontologie 10: 11-18.
4. Al-Sayyed, A., Deporter, D.A., Pilliar, R.M., Watson, P.A., Berhane, K. & Carter, S. (1994) Predictable crestal bone remodelling around two porous-coated titanium alloy dental implant designs. A radiographic study in dogs. Clinical Oral Implants Research 5: 131-141.
5. Apse, P., Ellen, R.P., Overall, C.M. & Zarb, G.A. (1989) Microbiota and crevicular fluid collagenase activity in the osseointegrated dental implant sulcus: a comparison of sites in edentulous and partially edentulous patients. Journal of Periodontal Research 24: 96-105.
6. Asikainen, P., Klemetti, E., Vuillemin, T., Sutter, F., Rainio, V. & Kotilainen, R. (1997) Titanium implants and lateral forces. An experimental study with sheep. Clinical Oral Implants Research 8: 465-468.
7. Augthun, M. & Conrads, G. (1997) Microbial findings of deep peri-implant bone defects. International Journal of Oral & Maxillofacial Implants 12: 106-112.
8. Barbier, L. &. Schepers, E. (1997) Adaptive bone remodeling around oral implants under axial and nonaxial loading conditions in the dog mandible. International Journal of Oral & Maxillofacial Implants 12: 215-223.
9. Becker, W., Becker, B.E., Newman, M.G. & Nyman, S. (1990) Clinical and microbiologic findings that may contribute to dental implant failure. International Journal of Oral and Maxillofacial Surgery 5: 31-38.
10. Berglundh, T., Lindhe, J., Marinello, C., Ericsson, I. & Liljenberg, B. (1992) Soft tissue reaction to de novo plaque formation on implants and teeth. An experimental study in the dog. Clinical Oral Implants Research 3: 1-8.
11. Bower, R.C., Radny, N.R., Wall, C.D. & Henry, P.J. (1989) Clinical and microscopic findings in edentulous patients 3 years after incorporation of osseointegrated implant-supported bridgework. Journal of Clinical Penodontology 16: 580-587.
12. Brägger, U., Bürgin, W., Fourmoussis, I. & Lang, N.P. (1992) Image processing for the evaluation of dental implants. Dentomaxillofacial Radiology 21: 208-212.
13. Brägger, U., Hafeli, U., Huber, B., Hämmerle, C.H. & Lang, N.P. (1998) Evaluation of postsurgical crestal bone levels adjacent to non-submerged dental implants. Clinical Oral Implants Research 9: 218-224.
14. Brånemark, P.I., Hansson, B.O., Adell, R., Breine, U., Lindström, J., Hallén, O. & Öhman, A. (1977) Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scandinavian Journal of Plastic and Reconstructive Surgery 16 (Suppl): 1-132.
15. Carr, A.B., Gerard, D.A. & Larsen, P.E. (1996) The response of bone in primates around unloaded dental implants supporting prostheses with different levels of fit. Journal of Prosthetic Dentistry 76: 500-509.
16. Ericsson, I., Berglundh, T., Marinello, C., Liljenberg, B. & Lindhe, J. (1992) Long-standing plaque and gingivitis at implants and teeth in the dog. Clinical Oral Implants Research 3: 99-103.
17. Ericsson, I., Persson, L.G., Glanz, P.O., Berglundh, T. & Lindhe, J. (1996) The effect of antimicrobial therapy on peri-implantitis lesions. An experimental study in the dog. Clinical Oral Implants Research 7: 320-328.
18. Frost, H.M. (1994) Wolff's law and bone's structural adaptations to mechanical usage: an overview for clinicians. Angle Orthodontist 64: 175-188.
19. George, K., Zafiropoulos, G.G., Murat, Y., Hubertus, S. & Nisengard, R.J. (1994) Clinical and microbiological status of osseointegrated implants. Journal of Penodontology 65: 766-770.
20. Gotfredsen, K., Berglundh, T. & Lindhe, J. (2001a) Bone reactions adjacent to titanium implants subjected to static load. A study in the dog (I). Clinical Oral Implants Research 12: 1-8.
21. Gotfredsen, K., Berglundh, T. & Lindhe, J. (2001b) Bone reactions adjacent to titanium implants with different surface characteristics subjected to static load. A study in the dog (II). Clinical Oral Implants Research 12: 196-201.
22. Gotfredsen, K., Berglundh, T. & Lindhe, J. (2001c) Bone reactions adjacent to titanium implants subjected to static load of different duration. A study in the dog (III). Clinical Oral Implants Research 12: 552-558.
23. Gotfredsen, K., Berglundh, T. & Lindhe, J. (2002) Bone reactions at implants subjected to experimental peri-implantitis and static load. Clinical Oral Implants Research 29: 144-151.
24. Hansson, S. (1999) The implant neck: smooth or provided with retention elements. A biomechanical approach. Clinical Oral Implants Research 10: 394-405.
25. Hämmerle, C.H.F., Brägger, U., Bürgin, W. & Lang, N.P. (1996) The effect of subcrestal placement of the polished surface of ITI implants on marginal soft and hard tissues. Clinical Oral Implants Research 7: 111-119.
26. Hoshaw, S.J., Brunski, J.B. & Cochran, G.V.B. (1994) Mechanical loading of Brånemark implants affects interfacial bone modeling and remodeling. International Journal of Oral & Maxillofacial Implants 9: 345-360.
27. Hürzeler, M.B., Quinones, C.R., Kohal, R.J., Rohde, M., Strub, J.R., Teuscher, U. & Caffesse, R.G. (1998) Changes in peri-implant tissues subjected to orthodontic forces and ligature breakdown in monkeys. Journal of Periodontology 69: 396-404.
28. Isidor, F. (1996) Loss of osseointegration caused by occlusal load of oral implants. A clinical and radiographic study in monkeys. Clinical Oral Implants Research 7: 143-152.
29. Isidor, F. (1997) Histological evaluation of peri-implant bone at implants subjected to occlusal overload or plaque accumulation. Clinical Oral Implants Research 8: 1-9.
30. Karnovsky, M.J. (1965) A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. Journal of Cell Biology 3: 112-119.
31. Kohavi, D., Greenberg, R., Raviv, E. & Sela, M.N. (1994) Subgingival and supragingival microbial flora around healthy osseointegrated implants in partially edentulous patients. International Journal of Oral & Maxillofacial Implants 9: 673-678.
32. Koka, S., Razzoog, M., Bloem, T.J. & Syed, S. (1993) Microbial colonization of dental implants in partially edentulous patients. Journal of Prosthetic Dentistry 70: 141-144.
33. Lang, N.P., Brägger, U., Walther, D., Beamer, B. & Komman, K.S. (1993) Ligature-induced peri-implant infection in cynomolgus monkeys. I. Clinical and radiographic findings. Clinical Oral Implants Research 4: 2-11.
34. Lang, N.P., Joss, A., Orsanic, T., Gusberti, F.A. & Siegrist, B.E. (1986) Bleeding on probing. A predictor for the progression of periodontal disease? Journal of Clinical Periodontology 13: 590-596.
35. Leonhardt, A., Adolfsson, B., Lekholm, U., Wickström, M. & Dahlén, G. (1993) A longitudinal microbiological study on osseointegrated titanium implants in partially edentulous patients. Clinical Oral Implants Research 4: 113-120.
36. Lindhe, J., Berglundh, T., Ericsson, I., Liljenberg, B. & Marinello, C. (1992) Experimental breakdown of peri-implant and periodontal tissues. Clinical Oral Implants Research 3: 9-16.
37. Lindquist, L.W., Rockler, B. & Carsson, G.E. (1988) Bone resorption around fixtures in edentulous patients treated with mandibular fixed tissue-integrated prostheses. Journal of Prosthetic Dentistry 59: 59-63.
38. Listgarten, M.A., Lang, N.P., Schroeder, H.E. & Schroeder, A. (1991) Periodontal tissues and their counterpart around endosseous implants. Clinical Oral Implants Research 21: 1-19.
39. Majzoub, Z., Finotti, M., Giarino, R., Aldini, N.N. & Cordioli, G. (1999) Bone response to orthodontic loading of endosseous implants in the rabbit calvaria: early continuous distalizing forces. European Journal of Orthodontics 21: 223-230.
40. Melsen, B. & Lang, N.P. (2001) Biological reactions of alveolar bone to orthodontic loading of oral implants. Clinical Oral Implants Research 12: 144-152.
41. Michaels, G.C., Carr, A.B. & Larsen, P.E. (1997) Effect of prosthetic superstructure accuracy on the osseointegrated implant bone interface. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 83: 198-205.
42. Miyata, T., Kobayashi, Y., Araki, H., Motomura, Y. & Shin, K. (1998) The influence of controlled occlusal overload on peri-implant tissue: a histologic study in monkeys. International Journal of Oral & Maxillofacial Implants 13: 677-683.
43. Miyata, T., Kobayashi, Y., Araki, H., Motomura, Y. & Shin, K. (2000) The influence of controlled occlusal overload on peri-implant tissue. Part 3: a histologic study in monkeys. International Journal of Oral & Maxillofacial Implants 15: 425-431.
44. Mombelli, A. (1999) Prevention and therapy of peri-implant infections. In: Lang, N.P., Karring, T. & Lindhe, J., eds. Proceedings of the Third European Workshop on Periodontology, 281-303. Berlin: Quintessenz Verlag.
45. Mombelli, A., Buser, D. & Lang, N.P. (1988) Colonization of osseointegrated titanium implants in edentulous patients. Early results. Oral Microbiology and Immunology 3: 113-120.
46. Mombelli, A., Feloutzis, A., Brägger, U. & Lang, N.P. (2001) Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results. Clinical Oral Implants Research 12: 287-294.
47. Mombelli, A. & Lang, N.P. (1992) Antimicrobial treatment of peri-implant infections. Clinical Oral Implants Research 3: 162-168.
48. Mombelli, A., Marxer, M., Gaberthüel, T., Grunder, U. & Lang, N.P. (1995) The microbiota of osseointegrated implants in patients with a history of periodontal disease. Journal of Clinical Periodontology 22: 124-130.
49. Mombelli, A. & Mericske-Stem, R. (1990) Microbiological features of stable osseointegrated implants used as abutments for overdentures. Clinical Oral Implants Research 1: 1-7.
50. Mombelli, A., Van Oosten, M.A.C., Schürch, E. & Lang, N.P. (1987) The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiology and Immunology 2: 145-151.
51. Naert, I., Quirynen, M., van Steenberghe, D. & Dariuw, P. (1992) A study of 589 consecutive implants supporting complete fixed prostheses. Part II: prosthetic aspects. Journal of Prosthetic Dentistry 68: 949-956.
52. Ogiso, M., Tabata, T., Kuo, T.P. & Borgese, D. (1994) A histologic comparison of the functional loading capacity of an occluded dense apatite implant and the natural dentition. Journal of Prosthetic Dentistry 71: 581-588.
53. Persson, L.G., Araujo, M., Berglundh, T., Gröndahl, K. & Lindhe, J. (1999) Resolution of peri-implantitis following treatment. An experimental study in the dog. Clinical Oral Implants Research 10: 195-203.
54. Persson, L.G., Ericsson, I., Berglundh, T. & Lindhe, J. (2001) Osseointegration following treatment of peri-implantitis and replacement of implant components. An experimental study in the dog. Journal of Clinical Periodontology 28: 258-263.
55. Pilliar, R.M., Deporter, D.A., Watson, P.A. & Valiquette, N. (1991) Dental implant design - effect on bone remodelling. Journal of Biomedical Materials Research 25: 467-483.
56. Pontoriero, R., Tonelli, M.P., Carnevale, G., Mombelli, A., Nyman, S.R. & Lang, N.P. (1994) Experimentally induced peri-implant mucositis. A clinical study in humans. Clinical Oral Implants Research 5: 254-259.
57. Quirynen, M. & Listgarten, M.A. (1990) The distribution of bacterial morphotypes around natural teeth and titanium implants ad modum Branemark. Clinical Oral Implants Research 1: 8-12.
58. Quirynen, M., Naert, I. & van Steenberghe, D. (1992) Fixture design and overload influence marginal bone loss and fixture success in the Brånemark system. Clinical Oral Implants Research 3: 1-8.
59. Rams, T.E. & Link, C.C. (1983) Microbiology of failing dental implants in humans: electron microscopic observations. Journal of Oral Implantology II: 93-100.
60. Rams, T.E., Roberts, T.W., Tatum, H. Jr. & Keyes, P.H. (1984) The subgingival microbial flora associated with human dental implants. Journal of Prosthetic Dentistry 51: 529-534.
61. Rangert, B., Krogh, P.H., Langer, B. & van Roekel, N. (1995) Bending overload and implant fracture: a retrospective clinical analysis. International Journal of Oral & Maxillofacial Implants 10: 326.
62. Roberts, W.E., Helm, F.R., Marshall, K.J. & Gongloff, R.K. (1989) Rigid endosseous implants for orthodontic and orthopedic anchorage. Angle Orthodontist 59: 247-256.
63. Roberts, W.E., Smith, R.K., Zilberman, Y., Mozsary, P.G. & Smith, R.S. (1984) Osseous adaptation to continuous loading of rigid endosseous implants. American Journal of Orthodontics 86: 95-111.
64. Salcetti, J.M., Moriarty, J.D., Cooper, L.F., Smith, S.W., Collins, J.G., Socransky, S.S. & Offenbacher, S. (1997) The clinical, microbial and host response characteristics of the failing implant. International Journal of Oral & Maxillofacial Implants 12: 32-42.
65. Sanz, M., Alandex, J., Lazaro, P., Calvo, J.L., Quirynen, M. & van Steenberghe, D. (1991) Histopathologic characteristics of peri-implant soft tissues in Branemark implants with 2 district clinical and radiological patterns. Clinical Oral Implants Research 2: 128-134.
66. Sanz, M., Newman, M.G., Nachnani, S., Holt, R., Stewart, R. & Fleming, T. (1990) Characterization of the subgingival microbial flora around endosteal sapphire dental implants in partially edentulous patients. International Journal of Oral & Maxillofacial Implants 5: 247-253.
67. Schenk, G., Flemmig, T.F., Betz, T., Reuther, J. & Klaiber, B. (1997) Controlled local delivery of tetracycline HCI in the treatment of periimplant mucosal hyperplasia and mucositis. Clinical Oral Implants Research 8: 427-433.
68. Schenk, R.K. & Buser, D. (1998) Osseointegration: a reality. Periodontology 2000 17: 22-35.
69. Schenk, R.K. & Olah, A.J. (1980) Histomorphometrie. In: Handbuch der inneren Medizin VI/1A, eds. Kuhlencordt, F. & Bartelheimer, H., pp. 437-494. Berlin, Heidelberg, New York: Springer.
70. Schenk, R.K., Olah, A.J. & Herrmann, W. (1984) Preparation of calcified tissues for light microscopy. In: Methods of calcified tissue preparation, eds. Dickson, G.R., pp. 1-56. Amsterdam: Elsevier.
71. Schou, S., Holmstrup, P., Reibel, J., Juhl, M., Hjorting-Hansen, E. & Komman, K.S. (1993) Ligature-induced marginal inflammation around osseointegrated implants and ankylosed teeth: stereologic and histologic observations in cynomolgus monkeys (Macaca fascicularis). Journal of Penodontology 64: 529-537.
72. Schroeder, A., van der Zypen, E., Stich, H. & Sutter, F. (1981) The reactions of bone, connective tissue and epithelium to endosteal implants with titanium-sprayed surfaces. Journal of Maxillofacial Surgery 9: 15-25.
73. Vaillancourt, H., Pilliar, R.M. & McCammond, D. (1996) Factors affecting crestal bone loss with dental implants partially covered with a porous coating: a finite element analysis. International Journal of Oral & Maxillofacial Implants II: 351-359.
74. Weber, H.P., Buser, D., Fiorellini, J.P. & Wilhams, R.C. (1992) Radiographic evaluation of crestal bone levels adjacent to nonsubmerged titanium implants. Clinical Oral Implants Research 3: 181-188.
75. Wehrbein, H. & Diedrich, P. (1993) Endosseous titanium implants during and after orthodontic load - an experimental study in the dog. Clinical Oral Implants Research 4: 76-82.
76. Wehrbein, H., Glatzmaier, J. & Yildirim, M. (1997) Orthodontic anchorage capacity of short titanium screw implants in the maxilla. An experimental study in the dog. Clinical Oral Implants Research 8: 131-141.
77. Weibel, E.R. (1980) Stereological methods: practical methods for biological morphometry. New York: Academic Press.
78. Wetzel, A.C., Vlassis, J., Caffesse, R.G., Hämmerle, C.H.F. & Lang, N.P. (1999) Attempts to obtain reosseointegration following experimental peri-implantitis in dogs. Clinical Oral Implants Research 10: 111-119.