Autoschizis: A new form of cell death for human ovarian carcinoma cells following ascorbate: Menadione treatment nuclear and DNA degradation

Tissue and Cell

Volumn 36, Issue 3, 2004, Pages 197-209

  Gilloteaux, Jacques ^a,b   Jamison, James M ^b   Lorimer, Heather E ^c   Jarjoura, David ^d   Taper, Henryk S ^e   Calderon, Pedro B ^e   Neal, Deborah R ^b   Summers, Jack L ^b  

^a American University of the Caribbean School of Medicine   (United States)

^b SUMMA HEALTH SYSTEM   (United States)

^c YOUNGSTOWN STATE UNIVERSITY   (United States)

^d Northeastern Ohio Medical University   (United States)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Ascorbate; Cell death; DNA; Menadione; Microscopy; Nucleus; Ovarian carcinoma

Indexed keywords

ASCORBIC ACID; DNA; MENADIONE;

ARTICLE; AUTOPHAGY; CARCINOMA CELL; CELL DEATH; CELL NUCLEUS; CELL ORGANELLE; CELL SIZE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CHROMATIN; CONTRAST SENSITIVITY; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; DENSITOMETRY; DNA DEGRADATION; DNA DETERMINATION; DNA METABOLISM; EXCISION REPAIR; FEULGEN STAINING; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; NUCLEOLUS; OPTICAL DENSITY; OVARY CARCINOMA;

EID: 3042524063     PISSN: 00408166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tice.2004.01.006     Document Type: Article

References (78)

1. Begleiter, A., 1983. Cytocidal action of the quinone group and its relationship to antitumor activity. Cancer Res. 43, 481-484.
2. Bellomo, G., Mirabelli, F., Vairetti, M., Iosi, F., Mallorni, W., 1990. Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: biochemical and immunocytochemical features. J. Cell Physiol. 143, 118-128.
3. Benade, L., Howard, T., Burk, D., 1969. Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3-amino-2,3,4-triazole. Oncology 23, 33-43.
4. Bram, K., Fridovich, I., 1981. DNA strand scission by enzymatically generated oxygen radicals. Arch. Biochem. Biophys. 206, 414-419.
5. Calderon, P.B., Cadrobbi, J., Marques, C., Hong-Ngoc, N., Jamison, J.M., Gilloteaux, J., Summers, J.L., Taper, H.S., 2002. Potential therapeutic application of the association of Vitamins C and K3 in cancer treatment. Curr. Med. Chem. 9, 2271-2285.
6. Cameron, E., Pauling, L., 1976. Supplemental ascorbate in the supportive treatment of cancer: reevaluation prolongation of survival times in terminal human cancer. Proc. Natl. Acad. Sci. U.S.A. 75, 4538-4542.
7. Cameron, E., Pauling, L., Leibovitz, B., 1979. Ascorbic acid and cancer: a review. Cancer Res. 39, 663-681.
8. Carbonera, D., Azzone, G.F., 1988. Permeability of inner mitochondrial membrane and oxidative stress. Biochim. Biophys. Acta 943, 245-255.
9. 3) is mediated by the Fas/Fas ligand system. Clin. Immunol. 93, 65-74.
10. Chakraborty, H., Ray, S.N., Chakrabarti, S., 2001. Lipid peroxidation associated protein damage in rat brain crude synaptosomal fraction mediated by iron and ascorbate. Neurochem. Int. 39, 311-317.
11. Daoust, R., Amano, H., 1963. Ribonuclease and deoxyribonuclase activities in experimental and human tumors by histochemical substrate film method. Cancer Res. 23, 131-134.
12. De Laurenzi, V., Melino, G., Savini, I., Annicchiarico-Petruzelli, M., Finazi-Agro, A., Avigliano, L., 1995. Cell death by oxidative stress and ascorbic acid regeneration in human neuroectodermal cell lines. Eur. J. Cancer 31A, 463-466.
13. 3) treatment on human tumor cell growth in vitro. II. Synergism with combined chemotherapy action. Anticancer Res. 13, 103-106.
14. de Tomasi, J.A., 1936. Improving the technique of the Feulgen stain. Stain Tech. 11, 137-144.
15. Dionisi, O., Galeotti, T., Terranova, T., Azzi, A., 1975. Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues. Biochem. Biophys. Acta 403, 292-300.
16. Duijndam, W.A.L., Van Duijn, P., 1975. The influence of chromatin compactness on the stoichiometry of the Feulgen-Schiff procedure studied in model films containing condensed or swollen chicken erythrocyte nuclei. J. Histochem. Cytochem. 23, 891-900.
17. 3-induced death of human bladder tumor cells. Scanning 20, 210-211.
18. Farber, J.L., Kyle, M.E., Coleman, J.B., 1990. The mechanisms of cell injury by activated oxygen species. Lab. Invest. 62, 670-679.
19. Freedman, R.S., Pihl, E., Kusyk, C., Gallagher, H.S., Rutledge, F., 1978. Characterization of an ovarian carcinoma cell line. Cancer 42, 2352-2359.
20. 3 combinations against human prostatic carcinoma cells. Scanning Microsc. Int. 9, 159-173.
21. 3 on human bladder carcinoma T24 cells. Scanning 20, 564-575.
22. 3 combinations against human T24 bladder carcinoma: another kind of cell death? Scanning 20, 208-210.
23. 3 combinations against human bladder carcinoma T24 cells: a new cell death by autoschizis. ISPO '98. Cancer Detect. Prevent. 22 (Suppl. 1), S-73.
24. 3 treatment. Scanning 22, 119-120.
25. Gilloteaux, J., Jamison, J.M., Arnold, D., Summers, J.L., 2001a. Autoschizis: another cell death for cancer cells induced by oxidative stress. In: Motta, P.M., Machiarelli, G., Nottola, S.A. (Eds.), Advances in Microanatomy of Cells and Tissues, Roma. Ital. J. Anat. Embryol. 106 (Suppl. 1), 79-91.
26. Gilloteaux, J., Jamison, J.M., Arnold, D., Taper, H.S., Summers, J.L., 2001b. Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells. Ultrastruct. Pathol. 25, 183-192.
27. Gilloteaux, J., Jamison, J.M., Arnold, D., von Greunigen, V.E., Summers, J.L., 2001c. Autoschizic death of human ovarian carcinoma (MDAH 2774) cells: LM and SEM aspects. Microsc. Microanal. 7 (Suppl. 2: Proc.), 586-587.
28. Gilloteaux, J., Jamison, J.M., Summers, J.L., 2001d. Cell death by autoschizis in human carcinoma cell lines: nucleus, DNA detection and degradation. Mol. Cell. Biol. 12, 497a.
29. 3 treatment. Microsc. Microanal. 9, 311-329.
30. Gilloteaux, J., Jamison, J.M., Arnold, D., Von Greuningen, V., Summers, J.L., 2003b. Autoschizis of human ovarian carcinoma cells: SEM and LM of a new cell death induced by sodium ascorbate:menadione treatment. Scanning 25, 137-149.
31. Hinshaw, D.B., Skalar, L.A., Bohl, B., Schraufstatter, I.U., Hyslop, P.A., Rossi, M.W., Spragg, R.G., Cochrane, C.G., 1986. Cytoskeletal and morphological impact of cellular oxidant injury. Am. J. Pathol. 123, 454-464.
32. Ishida, R., Takahashi, T., 1975. Increased DNA chain breakage by combined action of bleomycin and superoxide radical. Biochem. Biophys. Res. Commun. 66, 1432-1438.
33. 3 combinations against human prostate carcinoma cells. Tissue Cell 28, 687-701.
34. Jamison, J.M., Gilloteaux, J., Venugopal, M., Koch, J.A., Nicastro, E., Docherty, J.J., Jasso, J., Summers, J.L., 1997. Vitamin C and K3-induced oxidative stress in human prostate tumor cells: mitochondrial ultrastructural alterations. Microsc. Microanal. 3 (Suppl. 2), 23-24.
35. Jamison, J.M., Gilloteaux, J., Taper, H.S., Summers, J.L., 2001. Evaluation of the in vitro and in vivo antitumor activities of Vitamin C and Vitamin K3 combinations against human prostate cancer. J. Nutr. 131, 158S-160S,
36. Jamison, J.M., Gilloteaux, J., Taper, H.S., Calderon, P.B., Summers, J.L., 2002. Autoschizis: a novel cell death. Biochem. Pharmacol. 63, 1773-1783.
37. e treatment. Biochem. Pharmacol. 67, 337-351.
38. Jarabak, R., Jarabak, J., 1995. Effect of ascorbate on the DT-diaphorase-mediated redox cycling of 2-methyl-1,4-naphthoquinone. Arch. Biochem. Biophys. 318, 418-423.
39. Jemal, A., Murray, T., Samuels, A., Ghafoor, A., Ward, E., Thun, M., 2003. Cancer statistics. CA Cancer J. Clin. 53, 5-26.
40. Karnovsky, M.J., 1967. The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J. Cell Biol. 35, 213-236.
41. Keller, J.M., Cable, S., el Bouhtoury, F., Heusser, S., Scotto, C., Armbruster-Ciolek, E., Colin, S., Schilt, J., Dauca, M., 1993. Peroxisome through cell differentiation and neoplasia. Biol. Cell 77, 77-88.
42. Koch, C.J., Biaglow, J.E., 1978. Toxicity, radiation sensitivity modification, and metabolic effects of dehydroascorbate and ascorbate in mammalian cells. J. Cell Physiol. 94, 299-306.
43. Lesko, S.A., Lorentzen, R.J., Ts'o, P.O., 1980. Role of superoxide in deoxyribonucleic acid strand scission. Biochemistry 24, 3023-3028.
44. Leung, P.Y., Miyashita, K., Young, M., Tsao, C.S., 1993. Cytologic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines. Anticancer Res. 13, 475-480.
45. Lupulescu, A., 1991. Vitamin C inhibits DNA, RNA and protein synthesis in epithelial neoplastic cells. Int. J. Vitam. Nutt. Res. 61, 125-129.
46. Lupulescu, A., 1992. Ultrastructure and cell surface studies of cancer cells following Vitamin C administration. Exp. Toxicol. Pathol. 44, 3-9.
47. Malorni, W., Iosi, F., Mirabelli, F., Belomo, G., 1991. Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface blebs formation. Chem. Biol. Interact. 80, 217-235.
48. Maraldi, N.M., Zini, N., Santi, S., Ognibene, A., Rizzoli, R., Mazzoti, G., Manzoli, F.A., 1998. Cytochemistry of the functional domains of the nucleus in normal and in pathologic conditions. Eur. J. Histochem. 42, 41-53.
49. Minamitsuji-Mochizuki, C., Mitaka, T., Kojima, T., Niitsu, Y., Mochizuki, Y., 1999. Spontaneous appearance of circular actin bands in cultured hepatocytes of adult rats. Med. Electron Microsc. 32, 114-121.
50. Morgan, A.R., Cone, R.L., Elgert, T.M., 1976. The mechanism of DNA strand breakage by Vitamin C and superoxide and the protective roles of catalase and superoxide dismutase. Nucleic Acids Res. 3, 1139-1149.
51. Ngo, E.O., Sun, T.P., Chang, J.Y., Wang, C.C., Chi, K.H., Cheng, A.L., Nutter, L.M., 1991. Menadione-induced DNA damage in a human tumor cell line. Biochem. Pharmacol. 42, 1961-1968.
52. 3) treatment on human tumor cell growth in vitro. Cancer 63, 901-906.
53. Nutter, L.M., Cheng, A.L., Hung, H.I., Hsieh, R.K., Ngo, E.O., Liu, T.W., 1991. Menadione: spectrum of anticancer therapy and effects on nucleoside metabolism in human neoplastic cell lines. Biochem. Pharmacol. 41, 1283-1292.
54. Pearse, A.G.E., 1985. Histochemistry, Theoretical and Applied, 4th ed. Churchill Livingstone, Edinburgh, pp. 620-656.
55. Pething, R., Gascoyne, P.R.C., McLaughlin, J.A., Szent-Györgyi, A., 1983. Ascorbate-quinone interactions: electrochemical, free radical and cytotoxic properties. Proc. Natl. Acad. Sci. U.S.A. 80, 129-132.
56. 3 (Menadione) inhibits the growth of mammalian tumor cells in culture. Life Sci. 29, 1387-1392.
57. 3 (Menadione) Combinations over the Life Spans of C3H Inbred Mice, North Central Section American Urology Association Meeting, Vancouver, BC, 20 September 2003.
58. Ries, L.A., 1993. Ovarian cancer - survival and treatment differences by age. Cancer 71, 524-529.
59. Riordan, N.H., Riordan, H.D., Meng, X., Li, Y., Jackson, J.A., 1995. Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Mod. Hypothesis 44, 207-213.
60. Sakagami, H., Satoh, K., 1997. Modulating factors of radical intensity and cytotoxic activity of ascorbate (review). Anticancer Res. 17, 3513-3520.
61. Sambrook, R.J., Fritsch, E.F., Maniatis, T., 1989. Molecular Cloning, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring,Harbor, NY.
62. Sanger, J.W., Sanger, J.M., 1983. Differential response of three types of actin filament bundles to depletion of cellular ATP levels. Eur. J. Cell Biol. 31, 197-204.
63. Taper, H.S., 1967. L'activité des nucléases et phosphatases acides et alcalines dans les tumeurs rénales induites chez le rat par la diméthyl-nitrosamine (Etude histochimique). Path. Eur. 2, 406-420.
64. Taper, H.S., 1980. Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells. J. Histochem. Cytochem. 29, 1053-1060.
65. Taper, H.S., Fort, L., Brucher, J.M., 1971. Histochemical activity of alkaline and acid nucleases in rat liver parenchyma during N-nitrosomorpholine carcinogenesis. Cancer Res. 31, 913-916.
66. 3 vitamin pretreatment. Int. J. Cancer 40, 575-579.
67. Tsao, C.S., Dunham, W.B., Leung, P.Y., 1988. In vivo antineoplastic activity of ascorbic acid for human mammary tumor. In Vivo 2, 147-150.
68. 3 in mice bearing solid, transplantable tumor. Anticancer Res. 16, 499-504.
69. 3 combination. J. Histochem. Cytochem. 49, 109-119.
70. Varga, J.M., Airoldi, L., 1983. Inhibition of transplantable melanoma tumor development in mice by prophylactic administration of Ca-ascorbate. Life Sci. 32, 1559-1964.
71. 3 against human prostate carcinoma cell lines. Cell Biol. Int. 20, 787-797.
72. 3 on human urologic tumor cell lines. Life Sci. 59, 1389-1400.
73. Von Gruenigen, V.E., Jamison, J.M., Gilloteaux, J., Lorimer, H.E., Summers, M., Pollard, R.R., Gwin, C.A., Summers, J.L., 2003. The in vitro antitumor activity of Vitamins C and K-3 against ovarian carcinoma. Anticancer Res. 23, 3279-3287.
74. Wu, F.Y., Chang, N.T., Chen, W.J., Juan, C.C., 1993a. Vitamin K3-induced cell cycle arrest and apoptotic cell death are accompanied by altered expression of c-fos and c-myc in nasopharyngeal carcinoma cells. Oncogene 8, 2237-2244.
75. Wu, F.Y., Liao, W.C., Chang, H.M., 1993b. Comparison of antitumor activity of Vitamins K1, K2 and K3 on human tumor cells by two (MTT and SRB) cell viability assays. Life Sci. 52, 1797-1804.
76. Yamafuji, K., Nakamura, Y., Omura, H., Soeda, T., Gyotoku, K., 1971. Antitumor potency of ascorbic acid, dehydroascorbic or 2,3-diketogulonic acid and their action on deoxyribonucleic acid. Z. Krebsforsch. Onkol. Cancer Res. Clin. Oncol. 76, 1-7.
77. Yang, I., Chew, E.C., Chew-Cheng, S.B., Jiao, R.J., Yam, H.F., Zhai, Z.H., 1994. Fine structural observation of a nucleolar-nuclear matrix-lamina-intermediate filament system in transformed cells. Anticancer Res. 14, 1829-1832.
78. Zhang, W., Negoro, T., Satoh, K., Jiang, Y., Hashimoto, K., Kikuchi, H., Nishikawa, H., Miyata, T., Yamamoto, Y., Nakano, K., Yasumoto, E., Nakayachi, T., Mineno, K., Satoh, T., Sakagami, H., 2001. Synergistic cytotoxic action of Vitamin C and Vitamin K3. Anticancer Res. 21, 3439-3444.