Is immune-mediated complete fetal atrioventricular block reversible by transplacental dexamethasone therapy?

Ultrasound in Obstetrics and Gynecology

Volumn 23, Issue 6, 2004, Pages 602-605

  Jaeggi, E T ^a   Silverman, E D ^a   Yoo, S J ^a   Kingdom, J ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Bradycardia; Complete atrioventricular block; Dexamethasone; Doppler echocardiography; Fetal; Lupus erythematosus; Prenatal therapy; Steroids

Indexed keywords

DEXAMETHASONE; IMMUNOGLOBULIN; PREDNISONE; STEROID;

ADULT; ANAMNESIS; ARTICLE; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR CONDUCTION; CARDIOVASCULAR SYSTEM EXAMINATION; CASE REPORT; CLINICAL FEATURE; COMPLETE HEART BLOCK; CORTICOSTEROID THERAPY; DOPPLER ECHOCARDIOGRAPHY; ENDOCARDIAL FIBROELASTOSIS; FEMALE; FETUS; FETUS DISEASE; FETUS ELECTROCARDIOGRAPHY; FETUS MONITORING; HUMAN; IMMUNE MEDIATED INJURY; MEDICAL EXAMINATION; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADULT; DEXAMETHASONE; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; FETAL BLOOD; FETAL DISEASES; GLUCOCORTICOIDS; HEART BLOCK; HEART RATE, FETAL; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; PREGNANCY; PRENATAL CARE; ULTRASONOGRAPHY, PRENATAL;

EID: 3042518987     PISSN: 09607692     EISSN: None     Source Type: Journal    
DOI: 10.1002/uog.1056     Document Type: Article

References (13)

1. Hubscher O, Batista N, Rivero S, Marletta C, Arriagada M, Boire G, Menard HA, Arana RM. Clinical and serological identification of 2 forms of complete heart block in children. J Rheumatol 1995; 22: 1352-1355.
2. Ho SY, Esscher E, Anderson RH, Michaelsson M. Anatomy of congenital complete heart block and relation to maternal anti-Ro antibodies. Am J Cardiol 1996; 58: 291-294.
3. Gladman G, Silverman ED, Yuk-Law, Luy L, Boutin C, Laskin C, Smallhorn JF. Fetal echocardiographic screening of pregnancies of mothers with anti-Ro and/or anti-La antibodies. Am J Perinatol 2002; 19: 73-80.
4. Jaeggi ET, Hamilton RM, Silverman ED, Zamora SA, Hornberger LK. Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block. A single institution's experience of 30 years. J Am Coll Cardiol 2002; 39: 130-137.
5. Saleeb S, Copel J, Friedman D, Buyon JP. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody-associated congenital heart block: retrospective review of the research registry for neonatal lupus. Arthritis Rheum 1999; 42: 2335-2345.
6. Carvalho JS, Shinebourne EA, Kyle P. Efficacy unproved of maternal dexamethasone for fetal heart block. Am J Obstet Gynecol 1996; 175: 502-503.
7. Fouron JC, Proulx F, Miro J, Gosselin J. Doppler and M-mode ultrasonography to time fetal atrial and ventricular contractions. Obstet Gynecol 2000; 96: 732-736.
8. Glickstein JS, Buyon J, Friedman D. Pulsed Doppler echocardiographic assessment of the fetal PR interval. Am J Cardiol 2000; 86: 236-239.
9. Dancea A, Fouron JC, Miro J, Skoll A, Lessard M. Correlation between electrocardiographic and ultrasonographic time-interval measurements in fetal lamb heart. Pediatr Res 2000; 47: 324-328.
10. Rosenthal D, Friedman DM, Buyon J, Dubin A. Validation of the Doppler PR interval in the fetus. J Am Soc Echocardiogr 2002; 15: 1029-1030.
11. Rein AJ, O'Donnell C, Geva T, Nir A, Perles Z, Hashimoto I, Li XK, Sahn DJ. Use of tissue velocity imaging in the diagnosis of fetal cardiac arrhythmias. Circulation 2002; 106: 1827-1833.
12. Gould L, Reddy CV, Reidel J, Gomprecht RF. The effect of pharmacologic doses of steroids on atrioventricular conduction in man. J Clin Pharmacol 1975; 15: 262-268.
13. Zipes DP. Specific arrhythmias: diagnosis and treatment. In Heart Disease. A Textbook of Cardiovascular Medicine, Braunwald E (ed.). W. B. Saunders: Philadelphia, PA, 1997; 687-693.