A comparative randomized trial of intermittent intrahepatic arterial carboplatin- versus doxorubicin-lipiodol emulsion in advanced hepatocellular carcinoma (Stage IV)

Hepato-Gastroenterology

Volumn 51, Issue 58, 2004, Pages 1135-1139

  Homma, Hisato ^a   Mezawa, Shinichi ^a   Doi, Tadashi ^a   Miyanishi, Koji ^a   Takada, Kohichi ^a   Kukitsu, Takehiro ^a   Oku, Takaomi ^b   Masuko, Eiichi ^b   Nojiri, Shuuichi ^c   Niitsu, Yoshiro ^b  

^a Tokeidai Hospital   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Muroran City General Hospital   (Japan)

Author keywords

Advanced hepatocellular carcinoma; Carboplatin; Doxorubicin; Intrahepatic arterial infusion chemotherapy; Lipiodol

Indexed keywords

CARBOPLATIN; DOXORUBICIN; IODINATED POPPYSEED OIL; IOPAMIDOL;

ADULT; ADVANCED CANCER; ALOPECIA; ANOREXIA; ANTINEOPLASTIC ACTIVITY; ARTERY OCCLUSION; ARTICLE; BONE MARROW SUPPRESSION; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CATHETER INFECTION; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; EMULSION; FEMALE; FEVER; HEADACHE; HEART DISEASE; HEPATIC ARTERY; HUMAN; LEUKOPENIA; LIVER CELL CARCINOMA; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; NAUSEA; PANCYTOPENIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; STATISTICAL SIGNIFICANCE; STOMACH CANCER; STOMACH MUCOSA LESION; STOMACH ULCER; STOMATITIS; SURVIVAL RATE; THROMBOCYTOPENIA; TOXICITY;

AGED; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARCINOMA, HEPATOCELLULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; EMULSIONS; FEMALE; HUMANS; INFUSIONS, INTRA-ARTERIAL; IODIZED OIL; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 3042515481     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Yamada R, Satou M, Kawabata T, Nakatsuka H, Nakamura K, Takashima S: Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 1983; 148:397-401.
2. Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, et al: Natural history of hepatocellelar carcinoma and prognoses in relation to treatment, study of 850 patients. Cancer 1985; 56:918-928.
3. Sasaki Y, Imaoka S, Kasugai H, Fujita M, Kawamoto M, Ishiguro S, et al: A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin, and gelatin sponge. Cancer 1987; 60:1194-1203.
4. Nakamura H, Hashimoto T, Oi H, Sawada S: Transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 1989; 170:783-786.
5. Yodono H, Saito Y, Saikawa Y, Midorikawa H, Yokoyama Y, Takekawa S: Combination chemoembolization therapy for hepatocellular carcinoma: mainly, using cisplatin (CDDP). Cancer Chemother Pharmacol 1989; 23(Suppl):S42-S44.
6. Bismuth H, Morino M, Sherlock D, Castaing D, Miglietta C, Cauquil P, et al: Primary treatment of hepatocellular carcinoma by arterial chemoembolization. Am J Sung 1992; 163:387-394.
7. Aoyama K, Tsukishiro T, Okada K, Tsuchida T, Aiba N, Nambu S, et al: Evaluation of trranscatheter arterial embolization with epirubicin-lipiodol emulsion for hepatocellular carcinoma. Cancer Chemother Pharmacol 1992; 31(Suppl I):S55-S59.
8. Livraghi T, Bolondi L, Lazzaroni S, Marin G, Morabito A, Rapaccini GL, et al: Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients. Cancer 1992; 69:925-929.
9. Lencioni R, Caramella D, Bartolozzi C: Hepatocellular carcinoma: use of color Doppler US to evaluate response to treatment with percutaneous ethanol injection. Radiology 1995; 194:113-118.
10. Nagasue N, Yukaya H, Hamada T, Hirose S, Kanashima R, Inokuchi K: The natural history of hepatocellular carcinoma. Cancer 1984; 54:1461-1465.
11. Nakamura K, Takashima S, Takada K, Fujimoto K, Kaminou T, Nakatsuka H, et al: Clinical evaluation of intermittent arterial infusion chemotherapy with an implanted reservoir for hepatocellular carcinoma. Cancer Chemother Pharmacol 1992; 31(Suppl I):S93-S98.
12. Tyoda H, Nakano S, Kumada T, Takeda I, Sugiyama K, Osada T, et al: The efficacy of continuous local arterial infusion of 5-fluorouracil and cisplatin through an implanted reservoir for severe advanced hepatocellular carcinoma. Oncology 1995; 52:295-299.
13. Spiessl B, Beahrs OH, Hermanek P, Hutter RVP, Sheibe O, Sobin LH, et al: Illustrated guide to the TNM/pTNM-classification of malignant tumours. In: TNM atlas. 3rd Edition. Berlin Heidelberg New York London Tokyo: Springer, 1989; pp. 98-105.
14. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R: Transsection of the esophagus for bleeding oesophageal varices. Br J Surg 1973; 60:646-664.
15. Seldinger SI: Catheter replacement of the needle in percutaneous arteriography. Acta Radiol 1952; 39:368-376.
16. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-481.
17. Miller AB, Hoogstraten B, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer 1981; 47:207-214.
18. Minoyama A, Yoshikawa M, Ebara M, Saisho H, Sugiura N, Ohto M: Study of repeated arterial infusion chemotherapy with a subcutaneously implanted reservoir for advanced hepatocellular carcinoma. J Gastroenterol 1995; 30:356-366.
19. Miller D, O'reavy TJ, Griton M: Distribution of iodized oil within the liver after hepatic arterial injection. Radiology 1987; 162:849-851.
20. Nishizaki T, Takenaka K, Yoshida K, Ikeda T, Sugimachi K: Influence of lipiodolization on a cirrhotic liver. J Surg Oncol 1995; 58:263-268.
21. Canetta R, Rozencweig M, Carter SK: Carboplatin: the clinical spectrum to date. Cancer Treat Rev 1985; 12(Suppl A):125-136.
22. Harrap KR: Preclinical studies identifing carboplatin as a viable cisplatin alternative. Cancer Treat Rev 1985; 12(Suppl A):21-33.
23. Rose WC, Schurig JE: Preclinical antitumour and toxicologic profile of carboplastin. Cancer Treat Rev 1985; 1(Suppl 4):1-19.
24. Seshimo K, Hamasaki K, Gohda E, Orita K, Namba M: Effect of cisplatin, carboplatin, etoposide and human hepatocyte growth factor on the colony formation of four human liver cancer cell line. Jpn J Cancer Chemother 1993; 20:1967-1972.