Biosafe ginseng: A novel source for human well-being

Engineering in Life Sciences

Volumn 5, Issue 6, 2005, Pages 527-533

  Sivakumar, G ^a,b,c   Yu, K W ^a,b   Paek, K Y ^a,b  

^a Chungbuk National University   (South Korea)

^b CBN Biotech Co Ltd   (South Korea)

^c ENEA   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOREACTORS; CULTIVATION; MATHEMATICAL MODELS; MEDICINE; PLANTS (BOTANY); TISSUE CULTURE;

BIOACTIVE PHYTOMOLECULES; BIOCHEMICAL PATHWAYS; BIOREACTOR TISSUE MODELING; BIOSAFETY; GINSENG;

BIOTECHNOLOGY;

GINSENG EXTRACT; GINSENOSIDE; PESTICIDE; SAPONIN;

MEDICINAL PLANT;

AGAR MEDIUM; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BIOREACTOR; BIOSAFETY; DIET SUPPLEMENTATION; DRUG MANUFACTURE; DRUG RESEARCH; DRUG STRUCTURE; HAIRY ROOT CULTURE; HUMAN; MUTAGENICITY; NONHUMAN; PHYTONUTRIENT; PLANT BIOTECHNOLOGY; PLANT ROOT; PUBLIC HEALTH; QUALITY CONTROL; REVIEW; SPECIES CULTIVATION; STRUCTURE ANALYSIS; WELLBEING;

PANAX GINSENG;

EID: 30344480776     PISSN: 16180240     EISSN: None     Source Type: Journal    
DOI: 10.1002/elsc.200520100     Document Type: Review

References (30)

1. G. Sivakumar, K. W. Yu, E. J. Hahn, K. Y. Paek, Optimization of organic nutrients for ginseng hairy roots production in large-scale bioreactors, Current Sci. 2005, 89, 641-649.
2. G. Sivakumar, K. Y. Paek, Methyl jasmonate induce enhanced production of soluble biophenols in Panax ginseng adventitious roots from commercial scale bioreactors, Chem. Nat. Compd. 2005, in press.
3. P. Basu, Trading on traditional medicines, Nat. Biotechnol. 2004, 22, 263-265.
4. C. X. Qiao, R. Den, K. Kudo, K. Yamada, K. Takemoto, H. Wati, S. Kanba, Ginseng enhances contextual fear conditioning and neurogenesis in rats, Neurosci. Res. 2005, 51, 31-38.
5. C. Holden, The two faces of ginseng, Science 2004, 305, 1560.
6. S. H. Kim, K. S. Jeong, S. Y. Ryu, T. H. Kim, Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice, In vivo 1998, 12, 219-225.
7. M. Y. Jung, B. S. Jeon, J. Y. Bock, Free, esterified, and insoluble-bound phenolic acids in white and red Korean ginsengs (Panax ginseng C. A. Meyer), Food Chemistry 2002, 79, 105-111.
8. M. Mizuno, J. Yamada, H. Terai, N. Kozukue, Y. S. Lee, H. Tsuchida, Differences in immunomodulating effects between wild and cultured Panax ginseng, Biochem. Biophys. Res. Commun. 2002, 200, 1672-1678.
9. S. H. Ohh, Diseases of ginseng: environmental and host effect on disease outbreak and growth of pathogens, Korean J. Ginseng Sci. 1986, 5, 73-84.
10. G. Sivakumar, K. W. Yu, K. Y. Paek, Production of biomass and ginsenosides from adventitious roots of Panax ginseng in bioreactor cultures, Eng. Life Sci 2005, 5, 333-342.
11. K. Y. Paek, D. Chakrabarty, E. J. Hahn, Application of bioreactor systems for large scale production of horticultural and medicinal plants, Plant Cell Tissue Organ Cult. 2005, 81, 287-300.
12. N. T. Thanh, H. N. Murthy, K. W. Yu, E. J. Hahn, K. Y. Paek, Methyl jasmonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of Panax ginseng in 5-L balloon type bubble bioreactors, Appl. Microbiol. Biotechnol. 2005, 67, 197-201.
13. T. Murashige, F. Skoog, A revised medium for rapid growth and bioassays with tobacco tissue cultures, Physiol Plant 1962, 15, 23-28.
14. J. Wu, J. J. Zhong, Production of ginseng and its bioactive components in plant cell culture: Current technological and applied aspects, J. Biotechnol. 1999, 68, 89-99.
15. W. Tang, High-frequency plant regeneration via somatic embryogenesis and organogenesis and in vitro flowering of regenerated plantlets in Panax ginseng, Plant Cell Rep. 2000, 19, 727-732.
16. S. Arya, I. D. Arya, T. Eriksson, Rapid multiplication of adventitious somatic embryos of Partax ginseng, Plant Cell Tissue Organ Cult. 1993, 34, 157-162.
17. S. Arya, J. R. Liu, T. Eriksson, Plant regeneration from protoplasts of Panax ginseng (C. A. Meyer) through somatic embryogenesis, Plant Cell Rep. 1991, 10, 277-281.
18. Y. Shoyama, K. Kamura, I. Nishioka, Somatic embryogenesis and clonal multiplication of Panax ginseng, Planta Med. 1987, 54, 155-156.
19. Y. Furuya, T. Yoshikawa, Y. Ohihara, H. Oda, Saponin production in cell suspension cultures of Panax ginseng, Planta Med. 1983, 48, 83-87.
20. K. T. Choi, J. C. Park, I. O. Ahn, Saponin production in tissue culture of ginseng (Panax ginseng C. A. Meyer), Korean J. Ginseng Sci. 1990, 14, 107-111.
21. C. O. Akalezi, S. Liu, Q. S. Li, J. T. Yu, J. J. Zhong, Combined effects of initial sucrose concentration and inoculum size on cell growth and ginseng saponin production by suspension cultures of Panax ginseng, Process Biochem. 1999, 34, 639-642.
22. S. I. Gubar, T. P. Gulko, V. A. Kunkh, Growth and glycoside accumulation in ginseng callus tissue culture - a long-term action of exogenous phytohormones, Russian J. Plant Physiol. 1997, 44, 83-89.
23. M. Bonfill, R. M. Cusidó, J. Palazón, M. T. Piñol, C. Morales, Influence of auxins on organogenesis and ginsenoside production in Panax ginseng calluses, Plant Cell Tissue Organ Cult. 2002, 68, 73-78.
24. S. Liu, J. J. Zhong, Simultaneous production of ginseng saponin and polysaccharide by suspension cultures of Panax ginseng: nitrogen effects, Enzyme Microb. Technol. 1997, 21, 518-524.
25. S. Liu, J. J. Zhong, Phosphate effect of ginseng saponin and polysaccaride by cell suspension cultures of Panax ginseng and Panax quinquefolium, Process Biochem. 1998, 33, 69-74.
26. S. Inomata, M. Yokoyama, Y. Gozu, T. Shimizu, M. Yanagi, Growth pattern and ginsenoside production of Agrobacterium transformed Panax ginseng roots, Plant Cell Rep. 1993, 12, 681-686.
27. H. S. Lee, S. W. Kim, K. W. Lee, T. Eriksson, J. R. Liu, Agrobacterium mediated transformation of ginseng (Panax ginseng) and mitotic stability of the inserted β-glucuronidase gene in regenerants from isolated protoplasts, Plant Cell Rep. 1995, 14, 45-549.
28. K. W. Yu, H. N. Murthy, E. J. Hahn, K. Y. Paek, Ginsenoside production by hairy root cultures of Panax ginseng: influence of temperature and light quality, Biochem. Eng. J. 2005, 23, 53-56.
29. S. M. Choi, S. H. Son, S. R. Yun, O. W. Kwon, J. H. Seon, K. Y. Paek, Pilot-scale culture of adventitious roots of ginseng in a bioreactor system, Plant Cell Tissue Organ Cult 2000, 62, 187-193.
30. K. W. Yu, H. N. Murthy, C. S. Jeong, E. J. Hahn, K. Y. Paek, Organic germanium stimulates the growth of ginseng adventitious roots and ginsenoside production, Process Biochem. 2005, 40, 2959-2961.