Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families

International Immunology

Volumn 18, Issue 1, 2006, Pages 79-87

  Guo, Shuling ^a   Wahl, Matthew I ^a   Witte, Owen N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

B lymphocyte; Protein tyrosine kinase; Signal transduction; X linked agammaglobulinemia; X linked immunodeficiency

Indexed keywords

ABELSON KINASE; BRUTON TYROSINE KINASE; CALCIUM; HEMATOPOIETIC CELL KINASE; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; PROTEIN SH2; PROTEIN TYROSINE KINASE; TRYPTOPHAN;

AGAMMAGLOBULINEMIA; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOPRECIPITATION; IN VITRO STUDY; MISSENSE MUTATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; WESTERN BLOTTING; X CHROMOSOME LINKED DISORDER;

AMINO ACID SUBSTITUTION; ANIMALS; B-LYMPHOCYTES; CALCIUM SIGNALING; CELL LINE; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; PROTEIN-TYROSINE KINASES; SRC HOMOLOGY DOMAINS;

EID: 30344477956     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh351     Document Type: Article

References (40)

1. Sawyers, C. L. 2002. Rational therapeutic intervention in cancer: kinases as drug targets. Curr. Opin. Genet. Dev. 12:111.
2. Noble, M. E., Endicott, J. A. and Johnson, L. N. 2004. Protein kinase inhibitors: Insights into drug design from structure. Science 303:1800.
3. Vetrie, D., Vorechovsky I., Sideras, P. et al. 1993. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 361:226.
4. Tsukada, S., Saffran, D. C., Rawlings, D. J. et al. 1993. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72:279.
5. Thomas, J. D., Sideras, P., Smith, C. I., Vorechovsky, I., Chapman, V. and Paul, W. E. 1993. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 261:355.
6. Rawlings, D. J., Saffran, D. C., Tsukada, S. et al. 1993. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 261:358.
7. Khan, W. N., Alt, F. W., Gerstein, R. M. et al. 1995. Defective B cell development and function in Btk-deficient mice. Immunity 3:283.
8. Kerner, J. D., Appleby, M. W., Mohr, R. N. et al. 1995. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3:301.
9. Hendriks, R. W., de Bruijn, M. F., Maas, A., Dingjan, G. M., Karis, A. and Grosveld, F. 1996. Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO J. 15:4862.
10. Lindvall, J. M., Blomberg, K. E., Valiaho, J. et al. 2005. Bruton's tyrosine kinase: Cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling. Immunol. Rev. 203:200.
11. Fruman, D. A., Satterthwaite, A. B. and Witte, O. N. 2000. Xid-like phenotypes: A B cell signalosome takes shape. Immunity 13:1.
12. Guo, S., Ferl, G. Z., Deora, R. et al. 2004. A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation. Proc. Natl Acad. Sci. USA 101:14180.
13. Kang, S. W., Wahl, M. I., Chu, J. et al. 2001. PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J. 20:5692.
14. Park, H., Wahl, M. I., Afar, D. E. et al. 1996. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4:515.
15. Rawlings, D. J., Scharenberg, A. M., Park, H. et al. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822.
16. Harrison, S. C. 2003. Variation on an Src-like theme. Cell 112:737.
17. Hantschel, O. and Superti-Furga, G. 2004. Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat. Rev. Mol. Cell Biol. 5:33.
18. Xu, W., Harrison, S. C. and Eck, M. J. 1997. Three-dimensional structure of the tyrosine kinase c-Src: Nature 385:595.
19. Sicheri, F., Moarefi, I. and Kuriyan, J. 1997. Crystal structure of the Src family tyrosine kinase Hck. Nature 385:602.
20. LaFevre-Bernt, M., Sicheri F., Pico, A., Porter, M., Kuriyan, J. and Miller, W. T. 1998. Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue. J. Biol. Chem. 273:32129.
21. Briggs, S. D. and Smithgall, T. E. 1999. SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts. J. Biol. Chem. 274:26579.
22. Gonfloni, S., Frischknecht, F., Way, M. and Superti-Furga, G. 1999. Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis. Nat. Struct. Biol. 6:760.
23. Williams, B. L., Irvin, B. J., Sutor, S. L. et al. 1999. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. EMBO J. 18:1832.
24. Pelosi, M., Di Bartolo, V., Mounier, V. et al. 1999. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck. J. Biol. Chem. 274:14229.
25. Hong, J. J., Yankee, T. M., Harrison, M. L. and Geahlen, R. L. 2002. Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. J. Biol. Chem. 277:31703.
26. Brdicka, T., Kadlecek, T. A., Roose, J. P., Pastuszak, A. W. and Weiss, A. 2005. Intramolecular regulatory switch in ZAP-70: Analogy with receptor tyrosine kinases. Mol. Cell. Biol. 25: 4924.
27. Barila, D. and Superti-Furga, G. 1998. An intramolecular SH3-domain interaction regulates c-Abl activity. Nat. Genet. 18:280.
28. Brasher, B. B. and Van Etten, R. A. 2000. c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines. J. Biol. Chem. 275:35631.
29. Mao, C., Zhou, M. and Uckun, F. M. 2001. Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia: J. Biol. Chem. 276:41435.
30. Marquez, J. A., Smith, C. I., Petoukhov, M. V. et al. 2003. Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering. EMBO J. 22:4616.
31. Vihinen, M., Brandau, O., Branden, L. J. et al. 1998. BTKbase, mutation database for X-linked agammaglobulinemia (XLA). Nucleic Acids Res. 26:242.
32. Takata, M. and Kurosaki, T. 1996. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. J. Exp. Med. 184:31.
33. Afar, D. E., Park, H., Howell, B. W., Rawlings, D. J., Cooper, J. and Witte, O. N. 1996. Regulation of Btk by Src family tyrosine kinases. Mol. Cell. Biol. 16:3465.
34. Nisitani, S., Kato, R. M., Rawlings, D. J., Witte, O. N. and Wahl, M. I. 1999. In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies. Proc. Natl Acad. Sci. USA 96:2221.
35. Wahl, M. I., Fluckiger, A. C., Kato, R. M., Park, H., Witte, O. N. and Rawlings, D. J. 1997. Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proc. Natl Acad. Sci. USA 94:11526.
36. Satterthwaite, A. B., Cheroutre, H., Khan, W. N., Sideras, P. and Witte, O. N. 1997. Btk dosage determines sensitivity to B cell antigen receptor cross-linking. Proc. Natl Acad. Sci. USA 94: 13152.
37. Uckun, F. M., Waddick, K. G., Mahajan, S. et al. 1996. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science 273:1096.
38. McPherson, R. A., Taylor, M. M., Hershey, E. D. and Sturgill, T. W. 2000. A different function for a critical tryptophan in c-Raf and Hck. Oncogene 19:3616.
39. Middendorp, S., Dingjan, G. M., Maas, A., Dahlenborg, K. and Hendriks, R. W. 2003. Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity. J. Immunol. 171:5988.
40. Dal Porto, J. M., Gauld, S. B., Merrell, K. T., Mills, D., Pugh-Bernard, A. E. and Cambier, J. 2004. B cell antigen receptor signaling 101. Mol. Immunol. 41:599.