The inhibitory effect of bisphosphonates on glucocorticoid-induced RANKL expression in human cells

Scandinavian Journal of Rheumatology

Volumn 34, Issue 6, 2005, Pages 480-484

  Kobayashi, A ^a   Hirano, F ^a   Makino, I ^b  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b Megumino Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; ETIDRONIC ACID; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LUCIFERASE; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; SALICYLATE SODIUM; TILMACOXIB;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ASSAY; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SOLUBILITY; SUPERNATANT; T LYMPHOBLAST; TRANSCRIPTION REGULATION;

ANTI-INFLAMMATORY AGENTS; BONE DENSITY CONSERVATION AGENTS; CARRIER PROTEINS; DEXAMETHASONE; DIPHOSPHONATES; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; OSTEOBLASTS; OSTEOSARCOMA; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 30344474895     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.1080/03009740510026788     Document Type: Article

References (15)

1. Canalis E. Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 1996;81:3441-7.
2. Kitazawa R, Kitazawa S, Maeda S. Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim Biophys Acta 1999;1445:134-41.
3. Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, et al. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 1999;140:4382-9.
4. Ikeda T, Kasai M, Utsuyama M, Hirokawa K. Determination of three isoforms of the receptor activator of nuclear factor-κB ligand and their differential expression in bone and thymus. Endocrinology 2001;142:1419-26.
5. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 1999;96:3540-5.
6. Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 1997;390:175-9.
7. van Everdingen AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW. Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects, a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med 2002;136:1-12.
8. Rogers MJ. New insights into the molecular mechanisms of action of bisphosphonates. Curr Pharm Des 2003;9:2643-58.
9. Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G, Rogers MJ. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 1998;13:581-9.
10. Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res 1996;11:150-9.
11. Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest 1999;104:1363-74.
12. Mackie PS, Fisher JL, Zhou H, Choong PF. Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line. Br J Cancer 2001;84:951-8.
13. Kim Y H, Kim GS, Jeong-Hwa B. Inhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expression. Exp Mol Med 2002;34:145-51.
14. Roccisana JL, Kawanabe N, Kajiya H, Koide M, Roodman GD, Reddy SV. Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. J Biol Chem 2004;279:10500-7.
15. Kozawa O, Niwa M, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, et al. Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts. J Cell Biochem 2002;86:357-64.