Applying statistical design of experiments and automation to the rapid optimization of metal-catalyzed processes in process development

JALA - Journal of the Association for Laboratory Automation

Volumn 10, Issue 6, 2005, Pages 394-407

  McWilliams, J Christopher ^a   Sidler, D Richard ^a   Sun, Yongkui ^a   Mathre, David J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Automation; Chemoselective hydrogenation; Diastereoselective hydrogenation; DoE; Metal catalyzed reactions; Palladium; PPR; Process research; Reductive cyclization; Rhodium; Symyx; Vanadium doped platinum; Wilkinson's catalyst

Indexed keywords

AUTOMATION; CATALYSTS; HYDROGENATION; METALS; OPTIMIZATION; PALLADIUM; RHODIUM; STATISTICAL METHODS; STYRENE;

CHEMOSELECTIVE HYDROGENATION; DESIGN OF EXPERIMENTS (DOE); DIASTEREOSELECTIVE HYDROGENATION; METAL-CATALYZED REACTIONS; PROCESS RESEARCH; REDUCTIVE CYCLIZATION; VANADIUM DOPED PLATINUM; WILKINSONS CATALYSTS;

CATALYSIS;

AROMATIC NITRO COMPOUND; ESTER; HYDROGEN; METAL; NITRILE; PLATINUM; RHODIUM;

ARTICLE; CATALYSIS; COMPUTER PROGRAM; COMPUTER SYSTEM; CYCLIZATION; DIASTEREOISOMER; DRUG RESEARCH; DRUG SCREENING; HYDROGENATION; LABORATORY AUTOMATION; PHARMACEUTICAL ENGINEERING; PROCESS DESIGN; PROCESS OPTIMIZATION; STATISTICAL ANALYSIS;

EID: 30344474610     PISSN: 15355535     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2005.09.012     Document Type: Article

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