Sensitive and specific liquid chromatographic-tandem mass spectrometric assay for atropine and its eleven metabolites in rat urine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 40, Issue 1, 2006, Pages 142-150

  Chen, Huaixia ^a,b   Chen, Yong ^b   Du, Peng ^b   Han, Fengmei ^b   Wang, Hong ^a   Zhang, Huashan ^a  

^a WUHAN UNIVERSITY   (China)

^b HUBEI UNIVERSITY   (China)

Author keywords

Atropine; LC MSn; Metabolite

Indexed keywords

4 HYDROXYATROPINE; 4 HYDROXYATROPINE N OXIDE; ATROPINE; DRUG METABOLITE; GLUCURONIDE CONJUGATED 4 HYDROXYATROPINE; GLUCURONIDE CONJUGATED ATROPINE; GLUCURONIDE CONJUGATED N DEMETHYATROPINE; N DEMETHYLATROPINE; N DEMETHYLTROPINE; SULFATE CONJUGATED 4 HYDROXYATROPINE; SULFATE CONJUGATED ATROPINE; SULFATE CONJUGATED N DEMETHYLATROPINE; TROPINE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG METABOLISM; DRUG RETENTION; DRUG STRUCTURE; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ION MONITORING; LIQUID CHROMATOGRAPHY; METABOLITE; MOLECULAR WEIGHT; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ACETATES; ANIMALS; ATROPINE; CHEMISTRY, ANALYTICAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; HYDROLYSIS; MASS SPECTROMETRY; METHANOL; MODELS, CHEMICAL; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

EID: 30344473926     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.06.027     Document Type: Article

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