Chemical composition of and inhibition of angiotensin-converting enzyme by Senecio samnitum huet

Pharmaceutical Biology

Volumn 43, Issue 7, 2005, Pages 605-608

  Tundis, R ^a   Loizzo, M R ^a   Statti, G A ^a   Deguin, B ^b   Amissah, R ^c   Houghton, P J ^c   Menichini, F ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

ACE; Angiotensin converting enzyme; Compositae; Senecio samnitum

Indexed keywords

1-2 BENZENEDICARBOXYLIC ACID DIBUTYLESTER; 10 DEMETHYLSQUALENE; 22,24 DIMETHYLCHOLESTEROL; 4 HYDROXY BENZENACETIC ACID; 9,12 OCTADECANOIC ACID; 9,12,15 OCTADECATRIENOIC ACID METHYLESTER; ALPHA AMYRIN; ALPHA TOCOPHEROL; BEHENIC ACID; BETA AMYRIN; CHLOROGENIC ACID; DANSYLGLYCINE; DANSYLTRIGLYCINE; DIMETHYLESTER BUTANEDIOIC ACID; DIMETHYLESTER PROPANEDIOIC ACID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXY DIMETHYLESTER BUTANEDIOIC ACID; INTEGERRIMINE; PLANT EXTRACT; SENECIO SAMNITUM HUET EXTRACT; SENECIONINE; SENECIPHYLLINE; STEARIC ACID; STIGMASTA 5,22 DIEN 3 OL (3 BETA, 22E); UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CHROMATOPHORE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE;

ASTERACEAE; SENECIO;

EID: 30344460305     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200500301886     Document Type: Article

References (17)

1. Abrams WB, Davies RO, Ferguson RK (1984): Overview: The role of angiotensin converting enzyme inhibitors in vascular therapy. Fed Pro 43: 1314-1321.
2. Bah M, Bye R, Pereda-Miranda R (1994): Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae). J Ethnopharmacol 47: 19-30.
3. Bautista Peres J, Stubing G, Figuerola R (1991): Guia de las Plantas Medicinales de la Communidad Valenciana. Valencia, Las Provincial.
4. Bohlmann F, Zdero, C, Jakupovic J, Grenz M, Castro V, King RM, Robinson H, Vincent LPD (1986): Further pyrrolizidine alkaloids and furoeremophilanes from Senecio species. Phytochemistry 25: 1151-1159.
5. De Vivar AR, Pérez A-L, Vidales P, Nieto DA, Villaseñor JL (1996): Pyrrolizidine alkaloids from Senecio jacalensis and Senecio callosus. Biochem Sys Ecol 24: 175-176.
6. Duncan A, Jager AK, Van Staden J (1999): Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors. J Ethnopharmacol 68: 63-70.
7. Elbl G, Wagner H (1991): A new method for the in vitro screening of inhibitors of angiotensin converting enzyme (ACE), using the cromophore- and fluorophore-labeled substrate, dansyltriglicine. Planta Med 57: 137-141.
8. Hansen K, Nyman U, Wagner Smith U (1995): In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE). J Ethnopharmacol 48: 43-51.
9. Lacaille-Dubois MA, Franck U, Wagner H (2001): Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. Phytomedicine 8: 47-52.
10. Lee MA, BöHm M, Paul M, Ganten D (1993): Tissue rennin-angiotensin systems - Their role in cardiovascular disease. Circulation 87: S7-S13.
11. Liu K, Roder E (1991): Pyrrolizidine alkaloids from Senecio argunensis. Phytochemistry 30: 1303-1305.
12. Loyala LA, Pedreros S, Morales G (1985). P-Hydroxyacetophenone derivatives from Senecio graveolens. Phytochemistry 24 1600-1602.
13. Nyman U, Joshi P, Madsen LB, Pedersen TB, Pinstrup M, Rajasekharan S, George V, Pushpangadan P (1988): Ethnomedical information and in vitro screening for angiotensin-converting enzyme inhibition of plants utilized as traditional medicines in Gujarat, Rajasthan and Kerala (India). J Ethnopharmacol 60: 247-263.
14. Pérez C, Agnese AM, Cabrera JL (1999): The essential oil of Senecio graveolens (Compositae): Chemical composition and antimicrobial activity tests. J Ethnopharmacol 66: 91-96.
15. Pérez A-L, Vidales P, Cardenas, J, De Vivar R (1991): Eremophilanolides from Senecio toluccanus var. modestus. Phytochemistry 30: 905-908.
16. Rose EF (1972). Senecio species: Toxic plants used as food and medicine in the Transkei. S Afr Med 46: 1039-1043.
17. Urones JG, Barcala PB, Marcos IS, Moro RF, Esteban Lòpez M, Rodriguez F (1988): Pyrrolizidine alkaloids from Senecio gallicus and Senecio adonifolius. Phytochemistry 27: 1507-1510.