Trichloroethylene and dichloroethylene: A critical review of teratogenicity

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 73, Issue 12, 2005, Pages 931-955

  Hardin, Bryan D ^a,d   Kelman, Bruce J ^b   Brent, Robert L ^c  

^a Veritox Inc   (United States)

^b Veritox Inc   (United States)

^c NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^d NONE   (United States)

Author keywords

Birth weight; Congenital heart disease; Dichloroethylene; Environmental exposure; Spontaneous abortion; Trichloroethylene

Indexed keywords

DICHLOROETHYLENE; DRINKING WATER; ETHYLENE DERIVATIVE; TERATOGENIC AGENT; TRICHLOROETHYLENE; UNCLASSIFIED DRUG;

CONGENITAL HEART MALFORMATION; DEVELOPMENT; ENVIRONMENTAL EXPOSURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; TERATOGENESIS; WATER CONTAMINATION; WATER SUPPLY;

ABNORMALITIES, DRUG-INDUCED; ADULT; ANIMALS; ANIMALS, LABORATORY; DICHLOROETHYLENES; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; PREGNANCY; SOLVENTS; TERATOGENS; TRICHLOROETHYLENE; WATER POLLUTANTS, CHEMICAL;

EID: 30344454999     PISSN: 15420752     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdra.20192     Document Type: Review

References (63)

1. ATSDR. 1994. Toxicological profile for 1,1-dichloroethene. Agency for Toxic Substances and Disease Registry, 203 pp.
2. ATSDR. 1996. Toxicological profile for 1,2-dichloroethylene. Agency for Toxic Substances and Disease Registry, 198 pp.
3. ATSDR. 1997. Toxicological profile for trichloroethylene. Agency for Toxic Substances and Disease Registry, 335 pp.
4. ATSDR. 1998. Volatile organic compounds in drinking water and adverse pregnancy outcomes. NTIS Publication PB 98-156540. United States Marine Corps Base, Camp Lejuene, North Carolina, Final Report Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services, Atlanta, GA. 140 pp.
5. ATSDR. 2003. 2003 CERCLA priority list of hazardous substances that will be the subject of toxicological profiles and support document. Agency for Toxic Substances and Disease Registry, 38 pp.
6. Beliles RP, Brusick DJ, Mecler FJ. 1980. Teratogenic-mutagenic risk of workplace contaminants-trichloroethylene, perchloroethylene, and carbon disulfide. Final report to NIOSH. Contract 210-77-0047. NTIS PB 82-185075. National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH. 225 pp.
7. Bove FJ, Fulcomer MC, Klotz JB, et al. 1995. Public drinking water contamination and birth outcomes. Am J Epidemiol 141:850-862.
8. Bove FJ. 1996. Public drinking water contamination and birthweight, prematurity, fetal deaths, and birth defects. Toxicol Ind Health 12:255-266.
9. Bove F, Shim Y, Zeitz P. 2002. Drinking water contaminants and adverse pregnancy outcomes: a review. Environ Health Perspect. 110 (Suppl 1):61-74.
10. Boyer AS, Finch WT, Runyan RB. 2000. Trichloroethylene inhibits development of embryonic heart valve precursors in vitro. Toxicol Sci 53:109-117.
11. Brent RL. 1988. Predicting teratogenic and reproductive risks in humans from exposure to various environmental agents using in vitro techniques and in vivo animal studies. Cong Anomalies 28:S41-S55.
12. Bross G, DiFranceisco D, Desmond ME. 1983. The effects of low dosages of trichloroethylene on chick development. Toxicology 28:283-294.
13. Collier JM, Selmin O, Johnson PD, Runyan RB. 2003. Trichloroethylene effects on gene expression during cardiac development. Birth Defects Res Part A Clin Mol Teratol 67:488-495.
14. Cordier S, Ha MC, Ayme S, Goujard J. 1992. Maternal occupational exposure and congenital malformations. Scand J Work Environ Health 18:11-17.
15. Dawson BV, Johnson PD, Goldberg SJ, Ulreich JB. 1990. Cardiac teratogenesis of trichloroethylene and dichloroethylene in a mammalian model. J Am Coll Cardiol 16:1304-1309.
16. Dawson BV, Johnson PD, Goldberg SJ, Ulreich JB. 1993. Cardiac teratogenesis of halogenated hydrocarbon-contaminated drinking water. J Am Coll Cardiol 21:1466-1472.
17. Deane M, Swan SH, Harris JA, et al. 1989. Adverse pregnancy outcomes in relation to water contamination, Santa Clara County, California, 1980-1981. Am J Epidemiol 129:894-904.
18. Dorfmueller MA, Henne SP, York RG, et al. 1979. Evaluation of teratogenicity and behavioral toxicity with inhalation exposure of maternal rats to trichloroethylene. Toxicology 14:153-166.
19. Dyksen JE, Hess AF III. 1982. Alternatives for controlling organics in groundwater supplies. J Am Water Works Assoc 74:394-403.
20. Eggers J, Channel S, Graeter L, et al. 1999. Use of hematoxylin stain to enhance evaluation of heart malformations in the fetal rat. Teratology 59:173-175.
21. Elovaara E, Hemminki K, Vainio H. 1979. Effects of methylene chloride, trichloroethane, trichloroethylene, tetrachloroethylene and toluene on the development of chick embryos. Toxicology 12:111-119.
22. EPA Risk Assessment Forum. 1991. Guidelines for developmental toxicity risk assessment. Fed Reg 56:63789-63826.
23. Fisher JW, Channel SR, Eggers JS, et al. 2001. Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development? Int J Toxicol 20:257-267.
24. Goldberg SJ, Lebowitz MD, Graver EJ, Hicks S. 1990. An association of human congenital cardiac malformations and drinking water contaminants. J Am Coll Cardiol 16:155-164.
25. Goldberg SJ, Dawson BV, Johnson PD, et al. 1992. Cardiac teratogenicity of dichloroethylene in a chick model. Pediatr Res 32:23-26.
26. Hardin BD, Bond GP, Sikov MR, et al. 1981. Testing of selected workplace chemicals for teratogenic potential. Scand J Work Environ Health 7 (Suppl 4):66-75.
27. Hardin BD, Kelman BJ, Brent RL. 2004. Trichloroethylene and cardiac malformations [Letter]. Environ Health Perspect 112:A607-A608; author reply, A608-A609.
28. Healy TE, Poole TR, Hopper A. 1982. Rat fetal development and maternal exposure to trichloroethylene 100 p.p.m. Br J Anaesth 54:337-341.
29. Hill M. (2004) Chicken development stages. Available at: http://embryology.med.unsw.edu.au/OtherEmb/chick1.htm#hhtable. Accessed: February 21, 2005.
30. Hurtt ME, Valentine R, Alvarez L. 1993. Developmental toxicity of inhaled trans-1,2-dichloroethylene in the rat. Fundam Appl Toxicol 20:225-230.
31. IARC. 1995. Dry cleaning, some chlorinated solvents and other chemicals. IARC Monogr Eval Carcinog Risk Chem Hum 63.
32. Johnson PD, Dawson BV, Goldberg SJ. 1998a. Cardiac teratogenicity of trichloroethylene metabolites. J Am Coll Cardiol 32:540-545.
33. Johnson PD, Dawson BV, Goldberg SJ. 1998b. A review: trichloroethylene metabolites: potential cardiac teratogens. Environ Health Perspect 106 (Suppl 4):995-999.
34. Johnson PD, Goldberg SJ, Mays MZ, Dawson BV. 2003. Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat. Environ Health Perspect 111:289-292.
35. Johnson PD, Dawson BV, Goldberg SJ, Mays MZ. 2004. Correspondence: trichloroethylene: Johnson et al.'s Response. Environ Health Perspect 112:A608-A609.
36. Lagakos SW, Wessen JB, Zelen M. 1986. An analysis of contaminated well water and health effects in Woburn, Massachusetts. J Am Stat Assoc 81:583-596.
37. Lindbohm ML, Taskinen H, Sallmen M, Hemminki K. 1990. Spontaneous abortions among women exposed to organic solvents. Am J Ind Med 17:449-463.
38. Loeber CP, Hendrix MJ, Diez De Pinos S, Goldberg SJ. 1988. Trichloroethylene: a cardiac teratogen in developing chick embryos. Pediatr Res 24:740-744.
39. McMartin KI, Chu M, Kopecky E, et al. 1998. Pregnancy outcome following maternal organic solvent exposure: a meta-analysis of epidemiologic studies. Am J Ind Med 34:288-292.
40. MDPH. 1996. Woburn environment and birth study, synopsis. Available at: http://www.state.ma.us/dph/beha/cau/reports/woburn/synwebs1. pdf. 77 pp. Accessed March 8, 2004.
41. Rodenbeck SE, Maslia M. 1998. Use of groundwater modeling and GIS to determine population exposure to trichloroethylene (TCE) at the Tucson International Airport Area National Priorities List Site, Tucson, Arizona. Practice Periodical Hazard Toxic Radioactive Waste Manage 2:53-61.
42. Rodenbeck SE, Sanderson LM, Rene A. 2000. Maternal exposure to trichloroethylene in drinking water and birth-weight outcomes. Arch Environ Health 55:188-194.
43. Saillenfait AM, Langonne I, Sabate JP. 1995. Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture. Arch Toxicol 70:71-82.
44. rd Edition, Revised and Expanded.
45. Schwetz BA, Leong KJ, Gehring PJ. 1975. The effect of maternally inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats. Toxicol Appl Pharmacol 32:84-96.
46. Scialli AR, Gibb H. 2005. Trichloroethylene exposure and congenital heart defects [Letter]. Birth Defects Res A Clin Mol Teratol 73:255.
47. Skender LJ, Karacic V, Prpic-Majic D. 1991. A comparative study of human levels of trichloroethylene and tetrachloroethylene after occupational exposure. Arch Environ Health 46:174-178.
48. Sonnenfeld N, Hertz-Picciotto I, Kaye WE. 2001. Tetrachloroethylene in drinking water and birth outcomes at the US Marine Corps base at Camp Lejeune, North Carolina. Am J Epidemiol 154:902-908.
49. Staples RE. 1974. Detection of visceral alterations in mammalian fetuses. Teratology 9:A37-A38.
50. Swan SH, Shaw G, Harris JA, Neutra RR. 1989. Congenital cardiac anomalies in relation to water contamination, Santa Clara County, California, 1981-1983. Am J Epidemiol 129:885-893.
51. Taskinen HK. 1990. Effects of parental occupational exposures on spontaneous abortion and congenital malformation. Scand J Work Environ Health 16:297-314.
52. Taskinen H, Kyyronen P, Hemminki K, et al. 1994. Laboratory work and pregnancy outcome. J Occup Med 36:311-319.
53. TERIS. 2003. TERIS Summary-trichloroethylene, teratogen information system (TERIS). Agent 1242. University of Washington. 3 pp.
54. Tikkanen J, Heinonen OP. 1988. Cardiovascular malformations and organic solvent exposure during pregnancy in Finland. Am J Ind Med 14:1-8.
55. Tikkanen J, Kurppa K, Timonen H, et al. 1988. Cardiovascular malformations, work attendance, and occupational exposures during pregnancy in Finland. Am J Ind Med 14:197-204.
56. Tola S, Vilhunen R, Jarvinen E, Korkala ML. 1980. A cohort study on workers exposed to trichloroethylene. J Occup Med 22:737-740.
57. Wennborg H, Magnusson LL, Bonde JP, Olsen J. 2005. Congenital malformations related to maternal exposure to specific agents in biomedical research laboratories. J Occup Environ Med 47:11-19.
58. Westrick JJ, Mello JW, Thomas RF. 1984. The groundwater supply survey. J Am Water Works Assoc 76:52-59.
59. Wilson JG. 1965. Methods for administering agents and detecting malformations in experimental animals. In Wilson JG, Warkany T, editors. Teratology-principles and techniques. Chicago: University of Chicago Press, pp. 262-272.
60. Wilson JG. 1978. Review of in vitro systems with potential for use in teratogenicity screening. J Environ Pathol Toxicol 2:149-167.
61. Wrensch M, Swan S, Lipscomb J, et al. 1990. Pregnancy outcomes in women potentially exposed to solvent-contaminated drinking water in San Jose, California. Am J Epidemiol 131:283-300.
62. Yauck JS, Malloy ME, Blair K, et al. 2004. Proximity of residence to trichloroethylene-emitting sites and increased risk of offspring congenital heart defects among older women. Birth Defects Res Part A Clin Mol Teratol 70:808-814.
63. Zablotny CL, Carney EW, Dugard PH. 2002. Evaluation of trichloroethylene in a rat inhalation developmental toxicity study [Abstract 1161]. Toxicologist 66:237.