Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BKCa)

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 887-890

  Power, Eoin C ^a,b   Ganellin, C Robin ^a   Benton, David C H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Siena Biotech SpA   (Italy)

Author keywords

BKCa; Blocker; Large conductance; Opener; Potassium channels

Indexed keywords

ANILINE DERIVATIVE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; FUNCTIONAL GROUP; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; TOLUENESULFONIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM CONDUCTANCE; CONTROLLED STUDY; COW; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MUSCLE FIBER MEMBRANE CONDUCTANCE; NONHUMAN; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATTLE; DRUG EVALUATION, PRECLINICAL; KETOCONAZOLE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE TRANSPORT MODULATORS; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; BOVINAE;

EID: 30344454238     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.001     Document Type: Article

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