Diltiazem-induced neuroprotection in glutamate excitotoxicity and ischemic insult of retinal neurons

Documenta Ophthalmologica

Volumn 110, Issue 1, 2005, Pages 25-35

  Vallazza Deschamps, Géraldine ^a   Fuchs, Céline ^a   Cia, David ^a   Tessier, Luc Henri ^a   Sahel, José A ^a,b,c   Dreyfus, Henri ^a   Picaud, Serge ^a,c,d  

^a HÔPITAL SAINT ANTOINE   (France)

^b CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^c FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Calcium channel; Diltiazem; Excitotoxicity; Ischemia; Retina

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; DILTIAZEM; DIZOCILPINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; EXCITOTOXICITY; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; RAT; RETINA GANGLION CELL; RETINA ISCHEMIA; RETINA NERVE CELL; TREATMENT OUTCOME;

ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; CELL SURVIVAL; CELLS, CULTURED; DILTIAZEM; GLUTAMIC ACID; ISCHEMIA; NEURONS; NEUROTOXINS; RATS; RATS, WISTAR; RETINA; SWINE;

EID: 30344448016     PISSN: 00124486     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10633-005-7341-1     Document Type: Article

References (48)

1. Olney JW. The toxic effects of glutamate and related compounds in the retina and the brain. Retina 1982; 2: 341-359 6152914
2. Choi DW. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 1996; 6: 667-672 10.1016/S0959-4388(96)80101-2 8937832
3. De Boni U, Mclachlan DR. 1985 Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate. J Neurol Sci 1985; 68: 105-118 10.1016/ 0022-510X(85)90093-0 2861254
4. McGeer EG, McGeer PL. Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids. Nature 1976; 263: 517-519 10.1038/263517a0 9592
5. Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 1996; 114: 299-305 8600890
6. 2+-dependent kainate excitotoxicity in the chick embryonic neural retina ex vivo. Neuroreport 2000; 11: 3855-3858 11117503
7. 2+ entry via AMPA/KA receptors in the embryonic chick retina. Eur J Neurosci 1996; 8: 2499-2510 8996799
8. Casticas M, Allcorn S, Mobbs P. Early activation of Ca(2+)-permeable AMPA receptors reduces neurite outgrowth in embryonic chick retinal neurons. J Neurobiol 2001; 49: 200-211 10.1002/neu.1075 11745658
9. Graham ME, Burgoyne RD. Effects of calcium channel antagonists on calcium entry and glutamate release from cultured rat cerebellar granule cells. J Neurochem 1995; 65: 2517-2524 7595546
10. Ulshafer RJ, Sherry DM, Dawson R Jr, Wallace DR. Excitatory amino acid involvement in retinal degeneration. Brain Res 1990; 531: 350-354 10.1016/0006-8993(90)90800-Q 1981164
11. Brandstatter JH. Glutamate receptors in the retina: The molecular substrate for visual signal processing. Curr Eye Res 2002; 25: 327-331 10.1076/ceyr.25.6.327.14235 12789538
12. 2+ permeability mediate dendritic plasticity of retinal horizontal cells. Eur J Neurosci 1999; 11: 1085-1095 10.1046/j.1460-9568.1999.00516.x 10103101
13. Carvalho AL, Duarte CB, Faro CJ, Carvalho AP, Pires EV. Calcium influx through AMPA receptors and through calcium channels is regulated by protein kinase C in cultured retina amacrine-like cells. J Neurochem 1998; 70: 2112-2119 9572298
14. Ferreira IL, Duarte CB, Carvalho AP. Kainate-induced retina amacrine-like cell damage is mediated by AMPA receptors. Neuroreport 1998; 9: 3471-3475 9855301
15. Elmslie KS. Neurotransmitter modulation of neuronal calcium channels. J Bioenerg Biomembr 2003; 35: 477-489 10.1023/B:JOBB.0000008021.55853.18 15000517
16. Villa Pde la, Vaquero CF, Kaneko A. Two types of calcium currents of the mouse bipolar cells recorded in the retinal slice preparation. Eur J Neurosci 1998; 10: 317-323 10.1046/j.1460-9568.1998.00051.x 9753140
17. Pfeiffer-Linn CL, Lasater EM. Whole cell and single-channel properties of a unique voltage-activated sustained calcium current identified in teleost retinal horizontal cells. J Neurophysiol 1996; 75: 609-619 8714638
18. Wilkinson MF, Barnes S. The dihydropyridine-sensitive calcium channel subtype in cone photoreceptors. J Gen Physiol 1996; 107: 621-630 10.1085/ jgp.107.5.621 8740375
19. Costa VP, Harris A, Stefansson E, Flammer J, Krieglstein GK, Orzalesi N Heijl A, Renard JP, Serra LM. The effects of antiglaucoma and systemic medications on ocular blood flow. Prog Retin Eye Res 2003; 22: 769-805 10.1016/S1350-9462(03)00064-8 14575724
20. Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, Melena J Retinal ischemia: Mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res 2004; 23: 91-147 10.1016/j.preteyeres.2003.12.001 14766318
21. Frasson M, Sahel JA, Fabre M, Simonutti M, Dreyfus H, Picaud S. Retinitis pigmentosa: Rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med 1999; 5: 1183-1187 10.1038/13508 10502823
22. Heidinger V, Hicks D, Sahel J, Dreyfus H. Peptide growth factors but not ganglioside protect against excitotoxicity in rat retinal neurons in vitro. Brain Res 1997: 767: 279-288 10.1016/S0006-8993(97)00605-7 9367259
23. Gaudin C, Foster V, Sahel J, Dreyfus H, Hicks D. Survival and regeneration of adult human and other mammalian photoreceptors in culture. Invest Ophthalmol Vis Sci 1996; 37: 2258-2268 8843922
24. Picaud S, Hicks D, Forster V, Sahel J. Dreyfus H. Adult human retinal neurons in culture: Physiology of horizontal cells. Invest Ophthalmol Vis Sci 1998; 39: 2637-2648 9856773
25. Grant GB, Werblin FS Low-cost data acquisition and analysis programs for electrophysiology. J Neurosci Meth 1994; 55: 89-98 10.1016/ 0165-0270(94)90044-2
26. Weber M, Mohand-Said S, Hicks D, Dreyfus H, Sahel JA. Monosialoganglioside GM1 reduces ischemia-reperfusion-induced injury in the rat retina. Invest Ophthalmol Vis Sci 1996; 37: 267-273 8603830
27. Hughes TE. A light- and electron-microscopic investigation of the optic tectum of the frog, Rana pipiens. I: The retinal axons. Vis Neurosci 1990; 4: 499-518 2278931
28. Peritz E. Berkson's bias revisited. J Chronic Dis 1984; 37: 909-916 10.1016/0021-9681(84)90067-5 6396316
29. Frandsen A, Drejer J, Schousboe A. Direct evidence that excitotoxicity in cultured neurons is mediated via N-methyl-D-aspartate (NMDA) as well as non-NMDA receptors. J Neurochem 1989; 53: 297-299 2566655
30. Rogers DC, Hunter AJ. Dissociation of effects of glutamate receptor antagonists on excitotoxic and hypoxic neuronal cell death in a novel rat cortical culture system. Brain Res Bull 1997; 44: 131-139 10.1016/ S0361-9230(97)00102-0 9292202
31. 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J Neurosci 1994; 14: 187-197 7904304
32. Cebers G, Zhivotovsky B, Ankarcrona M, Liljequist S. AMPA neurotoxicity in cultured cerebellar granule neurons: Mode of cell death. Brain Res Bull 1997; 43: 393-403 10.1016/S0361-9230(97)00025-7 9241442
33. Randall RD, Thayer SA. Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J Neurosci 1992; 12: 1882-1895 1349638
34. Peichl L, Bolz J. Kainic acid induces sprouting of retinal neurons. Science 1984; 223: 503-504 6691162
35. Facci L, Leon A, Skaper SD. Excitatory amino acid neurotoxicity in cultured retinal neurons: Involvement of N-methyl-D-aspartate (NMDA) and nonNMDA receptors and effect of ganglioside GM1. J Neurosci Res 1990; 27: 202-210 10.1002/jnr.490270210 2174980
36. 2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina. Exp Eye Res 2000; 70: 475-484 10.1006/exer.1999.0809 10865996
37. Sucher NJ, Aizeman E, Lipton SA. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci 1991; 11: 966-971 1672708
38. Dreyer EB, Pan ZH, Storm S. Lipton SA. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport 1994; 5: 629-631 7912962
39. Kimura M, Katayama K, Nishizawa Y. Role of glutamate receptors and voltage-dependent calcium channels in glutamate toxicity in energy-compromised cortical neurons. Jpn J Pharmacol 1999; 80: 351-358 10.1254/jjp.80.351 10496336
40. Schurr A, Payne RS, Rigor BM, Synergism between diltiazem and MK-801 but not APV in protecting hippocampal slices against hypoxic damage. Brain Res 1995; 684: 233-236 10.1016/0006-8993(95)00466-4 7583230
41. Sucher NJ. Lei SZ, Lipton SA. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Res 1991; 551: 297-302 10.1016/0006-8993(91)90944-Q 1680525
42. Small DL, Monette R, Buchan AM, Morley P. Identification of calcium channels involved in neuronal injury in rat hippocampal slices subjected to oxygen and glucose deprivation. Brain Res 1997; 753: 209-218 10.1016/ S0006-8993(96)01385-6 9125405
43. Burns LH, Jin Z, Bowersox SS. The neuroprotective effects of intrathecal administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia. J Vasc Surg 1999; 30: 334-343 10436454
44. Osborne NN, Wood JP, Cupido A, Melena J, Chidlow G. Topical flunarizine reduces IOP and protects the retina against ischemia-excitotoxicity. Invest Ophthalmol Vis Sci 2002; 43: 1456-1464 11980861
45. Takahasi K, Lam TT, Edward ER, Buchi ER, Tso MO. Protective effects of flunarizine on ischemic injury in the rat retina. Arch Ophthalmol 1992; 110: 862-870 1596236
46. Block F, Schwarz M. The b-wave of the electroretinogram as an index of retinal ischemia. Gen Pharmacol 1998; 30: 281-287 10.1016/ S0306-3623(97)00359-5 9510075
47. Crosson CE, Willis JA, Potter DE. Effect of the calcium antagonist, nifedipine, on ischemic retinal dysfunction. J Ocul Pharmacol 1990; 6: 293-299 2097313
48. Nowicki JP, MacKenzie ET, Young AR. Brain ischaemia, calcium and calcium antagonists. Pathol Biol (Paris) 1982; 30: 282-288