Chemical synthesis and structural elucidation of a new serotonin metabolite: (4R)-2-[(5′-hydroxy-1′H-indol-3′-yl)-methyl] thiazolidine-4-carboxylic acid

Tetrahedron Letters

Volumn 47, Issue 6, 2006, Pages 943-946

  Jin, Chunyang ^a   Burgess, Jason P ^a   Gopinathan, Madathil B ^a   Brine, George A ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

5 HITCA; L Cysteine; Serotonin; Thiazolidine 4 carboxylic acid

Indexed keywords

2 [(5' HYDROXY 1'H INDOL 3' YL)METHYL]THIAZOLIDINE 4 CARBOXYLIC ACID; SEROTONIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CYCLIZATION; DIASTEREOISOMER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; POLYMERIZATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 30344447280     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.11.153     Document Type: Article

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9. 4) and concentrated in vacuo. Subsequent purification of the crude product by flash column chromatography over silica gel using MeOH/EtOAc as eluent provided 9 as a pale brown solid (3.85 g, 46%).
10. +: 415.1488. Found: 415.1492.
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