Highly chemoselective reduction using a Rh/C-Fe(OAc)2 system: Practical synthesis of functionalized indoles

Tetrahedron Letters

Volumn 47, Issue 6, 2006, Pages 969-972

  Akao, Atsushi ^a   Sato, Kimihiko ^a   Nonoyama, Nobuaki ^a   Mase, Toshiaki ^a   Yasuda, Nobuyoshi ^b  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; INDOLOCARBAZOLE GLYCOSIDE DNA TOPOISOMERASE INHIBITOR; RHODIUM; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CYCLIZATION; DEBENZYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION; REDUCTION; STEREOCHEMISTRY; SUBSTITUTION REACTION;

EID: 30344445698     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.11.145     Document Type: Article

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34. 2. After stirring for 20 min, the mixture was filtered to remove the catalyst, which was washed with THF (50 mL). The combined mixture was extracted with toluene (50 mL) and the organic layer was washed with aqueous citric acid (10%, 50 g), aqueous sodium bicarbonate (5%, 50 g) and brine (20%, 50 g). The yield of the target indole 4 was determined by HPLC (3.30 assay g, 96% yield).