Identification of polymorphisms explaining a linkage signal: Application to the GAW14 simulated data

BMC Genetics

Volumn 6, Issue SUPPL.1, 2005, Pages

  Chen, Ming Huei ^a   Van Eerdewegh, Paul ^b,d   Dupuis, Josée ^c  

^a Boston University   (United States)

^b Genizon BioSciences Inc   (Canada)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ERROR; ARTICLE; CHROMOSOME 1; CHROMOSOME 9; COMPUTER PROGRAM; CONTROLLED STUDY; DISEASE PREDISPOSITION; FAMILY STUDY; GENE IDENTIFICATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; INTERMETHOD COMPARISON; MATHEMATICAL COMPUTING; PERSONALITY DISORDER; POPULATION GENETICS; SCORING SYSTEM; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; COMPUTER SIMULATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC DATABASE; GENETICS; HUMAN; ORGANIZATION;

CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 9; COMPUTER SIMULATION; CONGRESSES AS TOPIC; DATABASES, GENETIC; GENETICS, POPULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 30344444970     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-6-S1-S88     Document Type: Article

References (5)

1. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI: Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 2000, 26:163-17S.
2. Li C, Scott LJ, Boehnke M: Assessing whether an allele can account in part for a linkage signal: the genotype-IBD sharing test (GIST). Am J Hum Genet 2004, 74:418-431.
3. Dupuis J, Van Eerdewegh R. Identification of polymorphisms that explain a linkage peak: conditioning on parental genotypes [abstract]. Genet Epidemiol 2003, 25:247.
4. Clayton D: A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 1999, 65: 1170-1177.
5. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES: Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996, 58:1347-1363.