Bispyridinium oximes as antidotal treatment of cyclosarin poisoning - In vitro and in vivo testing

International Journal of Toxicology

Volumn 24, Issue 6, 2005, Pages 399-402

  Bartosova, Lucie ^a   Kuca, Kamil ^a,b   Jun, Daniel ^a   Kunesova, Gabriela ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Cholinesterase; Cyclosarin; In Vitro; In Vivo; Reactivator; Species Differences

Indexed keywords

1 (3 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIO) 4 (2 HYDROXYIMINOMETHYLPYRIDINIO) 2 BUTENE DIBROMIDE; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; BIS(PYRIDINIUM OXIME) DERIVATIVE; BRAIN ENZYME; CYCLOSERINE; OBIDOXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; FEMALE; INTOXICATION; MOUSE; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALS; ANTIDOTES; ATROPINE; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FEMALE; KINETICS; LETHAL DOSE 50; MICE; MUSCARINIC ANTAGONISTS; OBIDOXIME CHLORIDE; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 30344444434     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810500366567     Document Type: Article

References (17)

1. Bajgar, J. 2004. Organophosphates/nerve agent poisoning: Mechanism of action, diagnosis, prophylaxis, and treatment. Adv. Clin. Chem. 38:151-216.
2. Bartosova, L., G. Kunesova, K. Kuca, and J. Vachek. 2004. Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice. Acta Med. (Hradec Králové) 47:249-251.
3. Cabal, J. K., K. Kuča, and J. Kassa. 2004. Specification of the structure of oximes able to reactivate tabun inhibited acetylcholinesterase. Bas. Clin. Pharmacol. Toxicol. 95:81-86.
4. Clement, J. G. 1992. Efficacy of various oximes against GF (cyclohexylmethylphosphonofluoridate) poisoning in mice. Arch. Toxicol. 66:143-144.
5. Gee, J. 1992. Iraqui declaration of chemical weapons: How much did they have and and what was it? Fourth International Symposium on Protection Against Chemical Warfare Agents, 8-12,. June, 1992, Stockholm, Sweden.
6. Kassa, J. 2002. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J. Toxicol. Clin. Toxicol. 6:803-816.
7. Kassa, J., and J. Bajgar. 1995. Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methyl-phosphonofluoridate (GF) in rats. Hum. Exp. Toxicol. 14:923-928.
8. Kassa, J., and J. Cabal. 1999. A comparison of the efficacy of acetylcholine reactivators against cyclohexylmethylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol. Toxicol. 84:41-45.
9. Koplovitz, I., V. C. Gresham, L. W. Dochterman, A. Kaminskis, and J. R. Stewart. 1992. Evaluation of the toxicity, pathology and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys. Arch. Toxicol. 66:622-628.
10. Kuca, K., and J. Kassa. 2003. A comparison of the ability of a new bispyridinium oxime - 1-(4-hydroxyiminomethylpyridinium)-4-(4- carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J. Enzyme Inhib. Med. Chem. 18:529-535.
11. Kuca, K., and J. Patocka. 2004. Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes. J. Enzyme Inhib. Med. Chem. 19:9-43.
12. Kuca, K., J. Patocka, and J. Cabal. 2003. Reactivation of organophosphate inhibited acetylcholinesterase activity by α,ω-bis-(4- hydroxyiminomethylpyridinium)alkanes in vitro. J. Appl. Biomed. 1:207-211.
13. Lucic, A., B. Radic, M. Peraica, M. Mesic, I. Primozic, and Z. Binenfeld. 1997. Antidotal efficacy of quinuclidinium oximes aganst soman poisoning. Arch. Toxicol. 71:467-470.
14. Lundy, P. M., A. S. Hansen, B. T. Hand, and C. A. Boulet. 1992. Comparison of several oximes against poisoning by soman, tabun and GF. Toxicology 72:99-105.
15. Roth, Z., M. Josifko, and V. Trcka. 1962. Statistical methods in experimental medicine. Statni zdravotnicke nakladatelstvi, Praha (in Czech).
16. Sevelova, L., K. Kuca, and G. Krejcova-Kunesova. 2005. Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes. Toxicology 207:1-6.
17. Tallarida, R., and R. Murray. 1987. Manual of pharmacological calculation with computer programs, 2nd ed. New York: Springer-Verlag.