Ethical issues in schizophrenia research: A commentary on some current concerns

Schizophrenia Bulletin

Volumn 32, Issue 1, 2006, Pages 26-29

  Shore, David ^a,b  

^a GEORGETOWN UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Consent capacity; Placebo; Research ethics; Schizophrenia

Indexed keywords

PLACEBO;

AWARENESS; CLINICAL RESEARCH; DRUG WITHDRAWAL; ETHICS; GOVERNMENT; HUMAN; MEDICAL EDUCATION; MENTAL DISEASE; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; SCHIZOPHRENIA;

BIOMEDICAL RESEARCH; DECISION MAKING; HUMANS; INFORMED CONSENT; MENTAL HEALTH SERVICES; RANDOMIZED CONTROLLED TRIALS; SCHIZOPHRENIA; UNITED STATES;

EID: 30344440374     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbj031     Document Type: Review

References (13)

1. Department of Heath and Human Services, Office for Protection from Research Risks. Code of Federal Regulations, Title 45: Public Welfare. Part 46: Protection of Human Subjects. Washington, D.C.; 1991.
2. Carpenter WT, Schooler NR, Kane J. The rationale and ethics of medication-free research in schizophrenia. Arch Gen Psychiatry. 1997;54:401-407.
3. Shore D, Hyman SE. NIMH symptom challenge and medication discontinuation workshop. Biol Psychiatry. 1999;46:1009-1010.
4. Shore D. Ethical principles and informed consent: an NIMH perspective. Psychopharmacol Bull. 1996;32:7-10.
5. Moser DJ, et al. Informed consent in medication-free schizophrenia research. Am J Psychiatry. 2005;162:1209-1211.
6. Roberts LW, et al. Schizophrenia patients' and psychiatrists' perspectives on ethical aspects of symptom reemergence during psychopharmacological research participation. Psychopharmacology. 2003;171:58-67.
7. Appelbaum PS, Roth LH, and Lidz C. The therapeutic misconception: Informed consent in psychiatric research. Int J Law Psychiatry 1982;5:319-329.
8. Roberts LW, Warner TD, Brody JL. Perspectives of patients with schizophrenia and psychiatrists regarding ethically important aspects of research participation. Am J Psychiatry. 2000;157:67-74.
9. Temple R, Ellenberg SS. Placebo controlled trials and active controlled trials in the evaluation of new treatments part I: ethical and scientific issues. Ann Intern Med. 2000;33:455-463.
10. Hyman SE, Shore D. An NIMH perspective on the use of placebos. Biol Psychiatry. 2000;47:689-691.
11. Emanuel EJ, Miller FG. The ethics of placebo-controlled trials - a middle ground. N Engl J Med. 2001;345:915-919.
12. Shore D, Hyman SE. An NIMH commentary on the NBAC report. Biol Psychiatry. 1999;46:1013-1016.
13. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research. Washington, D.C.: Government Printing Office; 1979.