Paralyzing and myotoxic effects of a recombinant bothropstoxin-I (BthTX-I) on mouse neuromuscular preparations

Experimental and Toxicologic Pathology

Volumn 57, Issue 3, 2006, Pages 239-245

  Gallacci, Márcia ^a   Oliveira, Maristela ^a   Pai Silva, Maeli Dal ^a   Cavalcante, Walter Luís Garrido ^a   Spencer, Patrick Jack ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

Author keywords

Muscle damage; Myotoxin; Phospholipase A2< inf>; Ultrastructure

Indexed keywords

HEPARIN; RECOMBINANT BOTHROPSTOXIN 1; RECOMBINANT PROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAPHRAGM; DRUG MECHANISM; EDEMA; EXTENSOR DIGITORUM LONGUS MUSCLE; IN VITRO STUDY; MALE; MORPHOLOGY; MOUSE; MUSCLE CELL; MUSCLE FIBRIL; MUSCLE INJURY; MYOGRAPHY; NONHUMAN; PARALYSIS; PHRENIC NERVE;

ANIMALIA; BOTHROPS JARARACUSSU; ESCHERICHIA COLI;

EID: 30344438237     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2005.09.004     Document Type: Article

References (10)

1. L. Chioato, A.H. De Oliveira, R. Ruller, J.M. Sa, and R.J. Ward Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2 Biochem J 366 2002 971 976
2. J.M. Gutierrez, and C.L. Ownby Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity Toxicon 42 2003 915 931
3. M.I. Homsi-Brandeburgo, L.S. Queiroz, H. Santo-Neto, L. Rodrigues-Simioni, and J.R. Giglio Fractionation of Bothrops jararacussu snake venom: partial chemical characterization and biological activity of bothropstoxin Toxicon 26 1988 615 627
4. B. Lomonte, A. Tarkowski, U. Bagge, and L.A. Hanson Neutralization of the cytolytic and myotoxic activities of phospholipases A2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family Biochem Pharmacol 9 1994 1509 1518
5. B. Lomonte, Y. Angulo, and L. Calderon An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action Toxicon 42 2003 885 901
6. J.F.A. Mc Manus, and R.W. Mowry Staining methods: histologic and biochemical medical division 1960 Harper & Brother New York p. 283-310
7. M. Oliveira, W.L.G. Cavalcante, E.Z. Arruda, P.A. Melo, M. Dal Pai-Silva, and M. Gallacci Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by suramin Toxicon 42 2003 373 379
8. P.J. Spencer, S.D. Aird, M. Boni-Mitake, N. Nascimento, and J.R. Rogero A single-step purification of bothropstoxin-I Braz J Med Biol Res 31 1998 1125 1127
9. P.J. Spencer, R. Webb, N. Nascimento, J.R. Rogero, and L. Smith Cloning, sequencing and expression of bothropstoxin-I Reunião Anual da Federação de Sociedades de Biologia Experimental vol. 15 2000 Resmos Caxambu 158
10. R.J. Ward, L. Chioato, A.H. de Oliveira, R. Ruller, and J.M. Sa Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis Biochem J 362 2002 89 96