Method for determining the average degree of substitution of o-vanillin derivatized porcine somatotropin

Journal of Pharmaceutical and Biomedical Analysis

Volumn 40, Issue 1, 2006, Pages 185-189

  Sharp, Thomas R ^a   Morris, Ronald ^a   Horan, George J ^a   Pezzullo, Linda H ^a   Stroh, Justin G ^a  

^a PFIZER INC   (United States)

Author keywords

Average degree of substitution measurement; o Vanillin; Porcine somatotropin; Protein derivatization

Indexed keywords

ALDEHYDE; GROWTH HORMONE; LYSINE; SCHIFF BASE; VANILLIN DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DERIVATIZATION; DRUG FORMULATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; SUBSTITUTION REACTION; SWINE;

ALDEHYDES; AMINO ACID SEQUENCE; ANIMALS; BENZALDEHYDES; CHEMISTRY, ANALYTICAL; CHEMISTRY, PHARMACEUTICAL; GROWTH HORMONE; LYSINE; MASS SPECTROMETRY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SWINE;

EID: 30344435902     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.06.028     Document Type: Article

References (12)

1. L. Margulis, C. Speaks, S. LeMott, N. Peckham, E. Shalaev, and R. Darrington 27th International Symposium on Controlled Release of Bioactive Materials Paris, France 2000
2. M.T. Clark, R.J. Gyurick, S.K. Lewis, M.C. Murray, M.J. Raymond, United States Patent 5,198,422, 30 March 1993.
3. T.O. Lindsey, M.T. Clark, PCT International Patent Application WO 92/01463, 6 February 1992.
4. B.A. Hay, M.T. Clark, PCT International Patent Application WO-00/00507, 6 January 2000.
5. L. Chantalat, N.D. Jones, F. Korber, J. Navaza, and A.G. Pavlovsky Protein Pept. Lett. 2 1995 333 340
6. F. Fenaille, P.A. Guy, and J.-C. Tabet J. Am. Soc. Mass Spectrom. 14 2003 215 226
7. M.S. Bolgar, and S.J. Gaskell Anal. Chem. 68 1996 2325 2330
8. Z. Liu, P.E. Minkler, and L.M. Sayre Chem. Res. Toxicol. 16 2003 901 911
9. A.L. Isom, S. Barnes, L. Wilson, M. Kirk, L. Coward, and V. Darley-Usmar J. Am. Soc. Mass Spectrom. 15 2004 1136 1147
10. B.B. Reinhold, and V.N. Reinhold J. Am. Soc. Mass Spectrom. 3 1992 207 215
11. J.C. Cottrell, B.N. Green, and J. Skilling 41st. ASMS Conference on Mass Spectrometry San Francisco, CA 31 May-4 June 1993
12. T.R. Sharp, R. Morris, G.J. Horan, L.H. Pezzullo, and J.G. Stroh 48th ASMS Conference on Mass Spectrometry Long Beach, CA 11-15 June 2000