메뉴 건너뛰기




Volumn 17, Issue 2, 2006, Pages 159-166

A new concept for bisphosphonate therapy: A rationale for the development of monthly oral dosing of ibandronate

(14)  Reginster, Jean Yves a   Felsenberg, Dieter b   Cooper, Cyrus c   Stakkestad, Jacob A d   Miller, Paul D e   Kendler, David L f   Adami, Silvano g   McClung, Michael R h   Bolognese, Michael A i   Civitelli, Roberto j   Dumont, Etienne k   Bonvoisin, Bernard l   Recker, Robert R m   Delmas, Pierre D n  


Author keywords

Bisphosphonate; Convenience; Ibandronate; Intermittent; Monthly; Osteoporosis

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; ETIDRONIC ACID; HISTAMINE H2 RECEPTOR ANTAGONIST; IBANDRONIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PAMIDRONIC ACID; PROTON PUMP INHIBITOR; RALOXIFENE; RISEDRONIC ACID; TILUDRONIC ACID; VITAMIN D;

EID: 30144440302     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-005-1957-6     Document Type: Review
Times cited : (33)

References (69)
  • 4
    • 0027229616 scopus 로고
    • Consequences of a hip fracture: A prospective study over 1 year
    • Sernbo I, Johnell O (1993) Consequences of a hip fracture: a prospective study over 1 year. Osteoporos Int 3:148-153
    • (1993) Osteoporos Int , vol.3 , pp. 148-153
    • Sernbo, I.1    Johnell, O.2
  • 6
    • 0009354424 scopus 로고    scopus 로고
    • Osteoporosis and its nonskeletal consequences: Their impact on treatment decisions
    • Marcus R, Feldman D, Kelsey J (eds) Academic Press, San Diego
    • Gold DT, Lyles KW, Shipp KM, Drezner MK (2001) Osteoporosis and its nonskeletal consequences: their impact on treatment decisions. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis, 2nd edn. Academic Press, San Diego, pp 4779-4784
    • (2001) Osteoporosis, 2nd Edn. , pp. 4779-4784
    • Gold, D.T.1    Lyles, K.W.2    Shipp, K.M.3    Drezner, M.K.4
  • 8
    • 0030964587 scopus 로고    scopus 로고
    • The socioeconomic burden of fractures: Today and in the 21st century
    • Johnell O (1997) The socioeconomic burden of fractures: today and in the 21st century. Am J Med 103:20S-26S
    • (1997) Am J Med , vol.103
    • Johnell, O.1
  • 9
    • 0026446492 scopus 로고
    • Hip fractures in the elderly: A worldwide projection
    • Cooper C, Campion G, Melton LJ (1992) Hip fractures in the elderly: a worldwide projection. Osteoporos Int 2:285-289
    • (1992) Osteoporos Int , vol.2 , pp. 285-289
    • Cooper, C.1    Campion, G.2    Melton, L.J.3
  • 10
    • 0030889653 scopus 로고    scopus 로고
    • Compliance with treatment regimens in chronic asymptomatic diseases
    • Miller NH (1997) Compliance with treatment regimens in chronic asymptomatic diseases. Am J Med 102:43-49
    • (1997) Am J Med , vol.102 , pp. 43-49
    • Miller, N.H.1
  • 12
    • 0142178332 scopus 로고    scopus 로고
    • Tolerability and compliance with risedronate in clinical practice
    • Hamilton B, McCoy K, Taggert H (2003) Tolerability and compliance with risedronate in clinical practice. Osteoporos Int 14:259-262
    • (2003) Osteoporos Int , vol.14 , pp. 259-262
    • Hamilton, B.1    McCoy, K.2    Taggert, H.3
  • 13
    • 0242288282 scopus 로고    scopus 로고
    • Compliance with alendronate treatment in an osteoporosis clinic
    • Lombas C, Hakim C, Zanchetta JR (2000) Compliance with alendronate treatment in an osteoporosis clinic. J Bone Miner Res 15 [Suppl 1]:M406
    • (2000) J Bone Miner Res , vol.15 , Issue.1 SUPPL.
    • Lombas, C.1    Hakim, C.2    Zanchetta, J.R.3
  • 15
    • 0142234682 scopus 로고    scopus 로고
    • Influence of patient compliance with risedronate therapy on bone turnover marker and bone mineral density response: The IMPACT study
    • abstract P-297
    • Eastell R, Garnero P, Vrijens B (2003) Influence of patient compliance with risedronate therapy on bone turnover marker and bone mineral density response: the IMPACT study (abstract P-297). Calcif Tissue Int 72:408
    • (2003) Calcif Tissue Int , vol.72 , pp. 408
    • Eastell, R.1    Garnero, P.2    Vrijens, B.3
  • 17
    • 24944570426 scopus 로고    scopus 로고
    • Clinical and economic impact of adherence to osteoporosis medication
    • abstract PL6
    • Caro J, Isak KJ, Huybrechts KF (2003) Clinical and economic impact of adherence to osteoporosis medication (abstract PL6). Osteoporos Int 14 [Suppl 7]:S2-S3
    • (2003) Osteoporos Int , vol.14 , Issue.7 SUPPL.
    • Caro, J.1    Isak, K.J.2    Huybrechts, K.F.3
  • 18
    • 0038450590 scopus 로고    scopus 로고
    • Bisphosphonates in the management of postmenopausal osteoporosis
    • Marcus R, Feldman D, Kelsey J (eds) Academic Press, New York
    • Papapoulos SE (2001) Bisphosphonates in the management of postmenopausal osteoporosis. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis, 2nd edn. Academic Press, New York, pp 631-649
    • (2001) Osteoporosis, 2nd Edn. , pp. 631-649
    • Papapoulos, S.E.1
  • 19
    • 0032622438 scopus 로고    scopus 로고
    • A medication use evaluation of alendronate: Compliance with administration guidelines
    • Mersfelder T Armitstead JA, Ivey MF, Cedars M (1999) A medication use evaluation of alendronate: compliance with administration guidelines. Pharm Pract Manag Q 18:10-58
    • (1999) Pharm Pract Manag Q , vol.18 , pp. 10-58
    • Mersfelder, T.1    Armitstead, J.A.2    Ivey, M.F.3    Cedars, M.4
  • 20
    • 0034871011 scopus 로고    scopus 로고
    • A systematic review of the associations between dose regimens and medication compliance
    • Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23:1296-1310
    • (2001) Clin Ther , vol.23 , pp. 1296-1310
    • Claxton, A.J.1    Cramer, J.2    Pierce, C.3
  • 21
    • 0036828449 scopus 로고    scopus 로고
    • Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosis
    • Rizzoli R, Greenspan SL, Bone G, Schnitzer TJ, for the Alendronate Once-Weekly Study Group (2002) Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosis. J Bone Miner Res 17:1988-1996
    • (2002) J Bone Miner Res , vol.17 , pp. 1988-1996
    • Rizzoli, R.1    Greenspan, S.L.2    Bone, G.3    Schnitzer, T.J.4
  • 24
    • 0036860290 scopus 로고    scopus 로고
    • Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: A multicenter randomized open-label, crossover study
    • Simon JA, Lewiecki M, Smith ME, Petruschke RA, Wang L, Palmisano JJ (2002) Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: a multicenter randomized open-label, crossover study. Clin Ther 24:1871-1886
    • (2002) Clin Ther , vol.24 , pp. 1871-1886
    • Simon, J.A.1    Lewiecki, M.2    Smith, M.E.3    Petruschke, R.A.4    Wang, L.5    Palmisano, J.J.6
  • 26
    • 15444375130 scopus 로고    scopus 로고
    • Medication persistence is better with weekly bisphosphonates, but it remains suboptimal
    • abstract SA407
    • Recker RR, Gallagher R, Amonkar M, Smith JC, MacCosbe PE (2004) Medication persistence is better with weekly bisphosphonates, but it remains suboptimal (abstract SA407). J Bone Miner Res 19 [Suppl 1]:S172
    • (2004) J Bone Miner Res , vol.19 , Issue.1 SUPPL.
    • Recker, R.R.1    Gallagher, R.2    Amonkar, M.3    Smith, J.C.4    MacCosbe, P.E.5
  • 27
    • 15444368170 scopus 로고    scopus 로고
    • Does dosing regimen impact persistence with bisphosphonate therapy among postmenopausal osteoporotic women
    • abstract M434
    • Cramer JA, Amonkar MM, Hebborn A, Suppapanya N (2004) Does dosing regimen impact persistence with bisphosphonate therapy among postmenopausal osteoporotic women (abstract M434)? J Bone Miner Res 19 [Suppl 1]:S448
    • (2004) J Bone Miner Res , vol.19 , Issue.1 SUPPL.
    • Cramer, J.A.1    Amonkar, M.M.2    Hebborn, A.3    Suppapanya, N.4
  • 28
    • 30144434162 scopus 로고    scopus 로고
    • Persistence and compliance with daily- and weekly-administered bisphosphonates in German women with osteoporosis ECCEO 2005 (Poster P195)
    • Bartl R, Goette S, Hadji P, Hammerschmidt T (2005) Persistence and compliance with daily- and weekly-administered bisphosphonates in German women with osteoporosis ECCEO 2005 (Poster P195)
    • (2005)
    • Bartl, R.1    Goette, S.2    Hadji, P.3    Hammerschmidt, T.4
  • 30
    • 0031671019 scopus 로고    scopus 로고
    • Esophageal irritation due to alendronate sodium tablets: Possible mechanisms
    • Peter CP, Handt LK, Smith SM (1998) Esophageal irritation due to alendronate sodium tablets: possible mechanisms. Dig Dis Sci 43:1998-2002
    • (1998) Dig Dis Sci , vol.43 , pp. 1998-2002
    • Peter, C.P.1    Handt, L.K.2    Smith, S.M.3
  • 32
    • 0033558504 scopus 로고    scopus 로고
    • Lineage commitment and maturation of epithelial cells in the gut
    • Karam SM (1999) Lineage commitment and maturation of epithelial cells in the gut. Front Biosic 4:D286-D298
    • (1999) Front Biosic , vol.4
    • Karam, S.M.1
  • 33
    • 3042643207 scopus 로고    scopus 로고
    • Ibandronate in osteoporosis: Preclinical data and rationale for intermittent dosing
    • Bauss F, Russell RGG (2004) Ibandronate in osteoporosis: preclinical data and rationale for intermittent dosing. Osteoporos Int 15:423-433
    • (2004) Osteoporos Int , vol.15 , pp. 423-433
    • Bauss, F.1    Russell, R.G.G.2
  • 34
    • 3042510892 scopus 로고    scopus 로고
    • Relative binding affinities of bisphosphonates for human bone
    • Leu C, Rodan GA, Reszka AA (2003) Relative binding affinities of bisphosphonates for human bone (abstract). J Bone Miner Res 18 [Suppl 2]:S374
    • (2003) J Bone Miner Res , vol.18 , Issue.2 SUPPL.
    • Leu, C.1    Rodan, G.A.2    Reszka, A.A.3
  • 39
    • 0028197320 scopus 로고
    • BM 21.0955, monosodium salt monohydrate
    • Bauss F, Mühlbauer RC (1994) BM 21.0955, monosodium salt monohydrate. Drugs Future 19:13-16
    • (1994) Drugs Future , vol.19 , pp. 13-16
    • Bauss, F.1    Mühlbauer, R.C.2
  • 40
    • 0034986001 scopus 로고    scopus 로고
    • Chemical and biological prerequisites for novel bisphosphonate molecules: Results of comparative preclinical studies
    • Green JF (2001) Chemical and biological prerequisites for novel bisphosphonate molecules: results of comparative preclinical studies. Semin Oncol 28 [Suppl 6]:4-10
    • (2001) Semin Oncol , vol.28 , Issue.6 SUPPL. , pp. 4-10
    • Green, J.F.1
  • 41
    • 0030802839 scopus 로고    scopus 로고
    • Ibandronate in malignant bone diseases and osteoporosis - Preclinical results
    • Bauss F (1997) Ibandronate in malignant bone diseases and osteoporosis - preclinical results. Onkologie 20:204-208
    • (1997) Onkologie , vol.20 , pp. 204-208
    • Bauss, F.1
  • 42
    • 4344580653 scopus 로고    scopus 로고
    • Daily and intermittent oral ibandronate normalize bone turnover and provide significant reduction in vertebral fracture risk: Results from the BONE study
    • Delmas PD, Recker RR, Chesnut CH III (2004) Daily and intermittent oral ibandronate normalize bone turnover and provide significant reduction in vertebral fracture risk: results from the BONE study. Osteoporos Int 15:792-798
    • (2004) Osteoporos Int , vol.15 , pp. 792-798
    • Delmas, P.D.1    Recker, R.R.2    Chesnut III, C.H.3
  • 43
    • 27744441423 scopus 로고    scopus 로고
    • Oral and intravenous ibandronate in the management of postmenopausal osteoporosis: A comprehensive review
    • submitted
    • Reginster J-Y (submitted) Oral and intravenous ibandronate in the management of postmenopausal osteoporosis: a comprehensive review. Curr Pharm Des
    • Curr Pharm Des
    • Reginster, J.-Y.1
  • 44
    • 0037273932 scopus 로고    scopus 로고
    • Effect of daily and intermittent use of ibandronate on bone mass and bone turnover in postmenopausal osteoporosis: A review of three phase II studies
    • Schimmer RC, Bauss F (2003) Effect of daily and intermittent use of ibandronate on bone mass and bone turnover in postmenopausal osteoporosis: a review of three phase II studies. Clin Ther 25:19-34
    • (2003) Clin Ther , vol.25 , pp. 19-34
    • Schimmer, R.C.1    Bauss, F.2
  • 46
    • 0036790869 scopus 로고    scopus 로고
    • Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties and bone concentration of ibandronate in ovariectomized aged rats
    • Bauss F, Lalla S, Endele R, Hothorn (2002a) Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties and bone concentration of ibandronate in ovariectomized aged rats. J Rheumatol 29:2200-2208
    • (2002) J Rheumatol , vol.29 , pp. 2200-2208
    • Bauss, F.1    Lalla, S.2    Endele, R.3    Hothorn4
  • 47
    • 0036246468 scopus 로고    scopus 로고
    • Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats
    • Bauss F, Wagner M, Hothorn LH (2002b) Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged rats. J Rheumatol 29:990-998
    • (2002) J Rheumatol , vol.29 , pp. 990-998
    • Bauss, F.1    Wagner, M.2    Hothorn, L.H.3
  • 48
    • 0029970562 scopus 로고    scopus 로고
    • The bisphosphonate ibandronate, given daily as well as discontinuously, decreases bone resorption and increases calcium retention as assessed by 45Ca kinetics in the intact rat
    • Fleisch H (1996) The bisphosphonate ibandronate, given daily as well as discontinuously, decreases bone resorption and increases calcium retention as assessed by 45Ca kinetics in the intact rat. Osteoporos Int 6:166-170
    • (1996) Osteoporos Int , vol.6 , pp. 166-170
    • Fleisch, H.1
  • 49
    • 0031972269 scopus 로고    scopus 로고
    • Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats
    • Lalla S, Hothorn LA, Haag N, Bader R, Bauss F (1998) Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats. Osteoporos Int 8:97-103
    • (1998) Osteoporos Int , vol.8 , pp. 97-103
    • Lalla, S.1    Hothorn, L.A.2    Haag, N.3    Bader, R.4    Bauss, F.5
  • 50
    • 0032851002 scopus 로고    scopus 로고
    • Intermittent and continuous administration of the bisphosphonate ibandronate in ovariohysterectomized beagle dogs: Effects on bone morphometry and mineral properties
    • Monier-Faugere MC, Geng Z, Paschalis EP, Qi Q, Arnala I, Bauss F, Boskey AL, Malluche HH (1999) Intermittent and continuous administration of the bisphosphonate ibandronate in ovariohysterectomized beagle dogs: effects on bone morphometry and mineral properties. J Bone Miner Res 14:1768-1778
    • (1999) J Bone Miner Res , vol.14 , pp. 1768-1778
    • Monier-Faugere, M.C.1    Geng, Z.2    Paschalis, E.P.3    Qi, Q.4    Arnala, I.5    Bauss, F.6    Boskey, A.L.7    Malluche, H.H.8
  • 51
    • 0037265864 scopus 로고    scopus 로고
    • Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys
    • Smith SY, Recker RR, Hannan M, Müller R, Bauss F (2003) Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys. Bone 32:45-55
    • (2003) Bone , vol.32 , pp. 45-55
    • Smith, S.Y.1    Recker, R.R.2    Hannan, M.3    Müller, R.4    Bauss, F.5
  • 52
    • 16644393178 scopus 로고    scopus 로고
    • Intermittent ibandronate preserves bone quality and bone strength in the lumbar spine after 16 months of treatment in the ovariectomized cynomolgus monkey
    • in press
    • Müller R, Hannan MK, Smith SY, Bauss F (in press) Intermittent ibandronate preserves bone quality and bone strength in the lumbar spine after 16 months of treatment in the ovariectomized cynomolgus monkey. J Bone Miner Res
    • J Bone Miner Res
    • Müller, R.1    Hannan, M.K.2    Smith, S.Y.3    Bauss, F.4
  • 53
    • 0027432707 scopus 로고
    • A new bisphosphonate, BM 21.0955, prevents bone loss associated with cessation of ovarian function in experimental dogs
    • Monier-Faugere MC, Friedler RM, Bauss F, Malluche HH (1993) A new bisphosphonate, BM 21.0955, prevents bone loss associated with cessation of ovarian function in experimental dogs. J Bone Miner Res 8:1345-1355
    • (1993) J Bone Miner Res , vol.8 , pp. 1345-1355
    • Monier-Faugere, M.C.1    Friedler, R.M.2    Bauss, F.3    Malluche, H.H.4
  • 54
    • 16244415479 scopus 로고    scopus 로고
    • Oral ibandronate has a similar gastrointestinal (GI) safety profile to placebo in patients with a history of GI disorders or receiving concomitant NSAIDs
    • abstract P267
    • Delmas PD, Emkey R, Gilbride J, Schimmer RC, Leishman B, Rosen CJ (2003) Oral ibandronate has a similar gastrointestinal (GI) safety profile to placebo in patients with a history of GI disorders or receiving concomitant NSAIDs (abstract P267). Osteoporos Int 14 [Suppl 7]:S74
    • (2003) Osteoporos Int , vol.14 , Issue.7 SUPPL.
    • Delmas, P.D.1    Emkey, R.2    Gilbride, J.3    Schimmer, R.C.4    Leishman, B.5    Rosen, C.J.6
  • 56
    • 0025366467 scopus 로고
    • Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis
    • Storm T, Thamsborg G, Steiniche T, Genant HK, Sorensen OH (1990) Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 323:1265-1271
    • (1990) N Engl J Med , vol.323 , pp. 1265-1271
    • Storm, T.1    Thamsborg, G.2    Steiniche, T.3    Genant, H.K.4    Sorensen, O.H.5
  • 57
    • 22744448254 scopus 로고    scopus 로고
    • Monthly oral ibandronate decreases bone turnover in postmenopausal women with low bone mass: Results from the Monthly Oral Pilot Study (MOPS)
    • abstract OC15
    • Reginster J-Y, Wiese C, Wilson K, Schimmer RC (2003) Monthly oral ibandronate decreases bone turnover in postmenopausal women with low bone mass: results from the Monthly Oral Pilot Study (MOPS) (abstract OC15). Osteoporos Int 14 [Suppl 7]:S5
    • (2003) Osteoporos Int , vol.14 , Issue.7 SUPPL.
    • Reginster, J.-Y.1    Wiese, C.2    Wilson, K.3    Schimmer, R.C.4
  • 58
    • 30144444591 scopus 로고    scopus 로고
    • Modelling the effects of ibandronate treatment on the time course of bone mineral density change in osteoporotic postmenopausal women
    • abstract P-280
    • Geischke R, Hayashi N, Vis P, Jacqmin P (2003) Modelling the effects of ibandronate treatment on the time course of bone mineral density change in osteoporotic postmenopausal women (abstract P-280). Calcif Tissue Int 72:404
    • (2003) Calcif Tissue Int , vol.72 , pp. 404
    • Geischke, R.1    Hayashi, N.2    Vis, P.3    Jacqmin, P.4
  • 59
    • 0142027576 scopus 로고    scopus 로고
    • Study designs in osteoporosis
    • Temple RJ (2003) Study designs in osteoporosis. J Bone Miner Res 18:1129-1132
    • (2003) J Bone Miner Res , vol.18 , pp. 1129-1132
    • Temple, R.J.1
  • 60
    • 77949392212 scopus 로고    scopus 로고
    • Declaration of Helsinki: Ethical principles for medical research involving human subjects
    • 3-7 October 2000, Edinburgh, Scotland
    • World Medical Association (2000) Declaration of Helsinki: ethical principles for medical research involving human subjects. 52nd World Medical Association General Assembly, 3-7 October 2000, Edinburgh, Scotland
    • (2000) 52nd World Medical Association General Assembly
  • 61
    • 0034456357 scopus 로고    scopus 로고
    • Antifracture efficacy of antiresorptive agents are related to changes in bone density
    • Wasnich RD, Miller PD (2000) Antifracture efficacy of antiresorptive agents are related to changes in bone density. J Clin Endocrinol Metab 85:231-236
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 231-236
    • Wasnich, R.D.1    Miller, P.D.2
  • 62
    • 0036284616 scopus 로고    scopus 로고
    • Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents
    • Hochberg MC, Greenspan S, Wasnich RD, Miller P, Thompson DE, Ross PD (2002) Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab 87:1586-1592
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1586-1592
    • Hochberg, M.C.1    Greenspan, S.2    Wasnich, R.D.3    Miller, P.4    Thompson, D.E.5    Ross, P.D.6
  • 63
    • 0142122888 scopus 로고    scopus 로고
    • Surrogates for fracture endpoints in clinical trials
    • Khosla S (2003) Surrogates for fracture endpoints in clinical trials. J Bone Miner Res 18:1146-1149
    • (2003) J Bone Miner Res , vol.18 , pp. 1146-1149
    • Khosla, S.1
  • 64
    • 4444236655 scopus 로고    scopus 로고
    • Changes in bone mineral density as a predictor for vertebral fracture efficacy with ibandronate: Results from a phase III fracture study
    • abstract SA353
    • Wasnich R, Miller PD, Chesnut CH, Huss H, Wilson K, Schimmer RC (2003) Changes in bone mineral density as a predictor for vertebral fracture efficacy with ibandronate: results from a phase III fracture study (abstract SA353). J Bone Miner Res 18 [Suppl 2]:S160
    • (2003) J Bone Miner Res , vol.18 , Issue.2 SUPPL.
    • Wasnich, R.1    Miller, P.D.2    Chesnut, C.H.3    Huss, H.4    Wilson, K.5    Schimmer, R.C.6
  • 65
    • 2942739433 scopus 로고    scopus 로고
    • Relationship between changes in biochemical markers of bone turnover and BMD to predict vertebral fracture risk
    • Sarkar S, Reginster JY, Crans GG, Diez-Perez A, Pinette KV, Delmas PD (2004) Relationship between changes in biochemical markers of bone turnover and BMD to predict vertebral fracture risk. J Bone Miner Res 19:394-401
    • (2004) J Bone Miner Res , vol.19 , pp. 394-401
    • Sarkar, S.1    Reginster, J.Y.2    Crans, G.G.3    Diez-Perez, A.4    Pinette, K.V.5    Delmas, P.D.6
  • 67
    • 0003828057 scopus 로고    scopus 로고
    • The European Agency for the Evaluation of Medicinal Products, London
    • Committee for Proprietary Medicinal Products (CPMP) (2000) Points to consider on switching between superiority and non-inferiority. The European Agency for the Evaluation of Medicinal Products, London
    • (2000) Points to Consider on Switching between Superiority and Non-inferiority
  • 68
    • 0029855832 scopus 로고    scopus 로고
    • The effect on bone mass and bone markers of different doses of ibandronate: A new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: A 1 year, randomised, double-blind, placebo controlled dose finding study
    • Ravn P, Clemmesen B, Riis BJ, Christiansen C (1996) The effect on bone mass and bone markers of different doses of ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: a 1 year, randomised, double-blind, placebo controlled dose finding study. Bone 19:527-533
    • (1996) Bone , vol.19 , pp. 527-533
    • Ravn, P.1    Clemmesen, B.2    Riis, B.J.3    Christiansen, C.4
  • 69
    • 0034814098 scopus 로고    scopus 로고
    • Ibandronate: A comparison of oral daily dosing versus intermittent dosing in postmenopausal osteoporosis
    • Riis BJ, Ise J, Von Stein T, Bagger Y, Christiansen C (2001) Ibandronate: a comparison of oral daily dosing versus intermittent dosing in postmenopausal osteoporosis. J Bone Miner Res 16:1871-1878
    • (2001) J Bone Miner Res , vol.16 , pp. 1871-1878
    • Riis, B.J.1    Ise, J.2    Von Stein, T.3    Bagger, Y.4    Christiansen, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.