Human glutathione transferase A3-3 active as steroid double-bond isomerase

Methods in Enzymology

Volumn 401, Issue , 2005, Pages 265-278

  Raffalli Mathieu, Françoise ^a   Mannervik, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; CHOLESTEROL; GLUTATHIONE TRANSFERASE; ISOMERASE; PRASTERONE; PREGNENOLONE; PROGESTERONE; STEROID;

ARTICLE; CELL PROTECTION; ELECTROPHORESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEROID METABOLISM; STEROIDOGENESIS;

EID: 30144436351     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)01017-7     Document Type: Review

References (20)

1. 5-3-ketosteroid isomerase reaction of liver Biochem. Biophys. Res. Commun. 69 1976 1073 1079
2. 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver Proc. Natl. Acad. Sci. USA 74 1977 158 162
3. Björnestedt R., Widersten M., Board P.G., and Mannervik B. Design of two chimaeric human-rat class Alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties Biochem. J. 282 1992 505 510
4. Board P.G. Identification of cDNAs encoding two human Alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4 Biochem. J. 330 1998 827 831
5. Eliasson M., Stark T., and DePierre J.W. Expression of glutathione transferase isoenzymes in the porcine ovary in relationship to follicular maturation and luteinization Chem. Biol. Interact. 117 1999 35 48
6. Fayad T., Levesque V., Sirois J., Silversides D.W., and Lussier J.G. Gene expression profiling of differentially expressed genes in granulosa cells of bovine dominant follicles using suppression subtractive hybridization Biol. Reprod. 70 2004 523 533
7. Gu Y., Guo J., Pal A., Pan S.-S., Zimniak P., Singh S.V., and Ji X. Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity Biochemistry 43 2004 15673 15679
8. Hayes J.D., Flanagan J.U., and Jowsey I.R. Glutathione transferases Annu. Rev. Pharmacol. Toxicol. 45 2005 51 88
9. Johansson A.-S., and Mannervik B. Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones J. Biol. Chem. 276 2001 33061 33065
10. Johansson A.-S., and Mannervik B. Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3 J. Biol. Chem. 277 2002 16648 16654
11. Mannervik B., and Widersten M. Glutathione transferases G.M. Pacifici G.N. Fracchia "Advances in Drug Metabolism in Man" 1995 European Commission Luxembourg 407 459
12. Morel F., Rauch C., Coles B., Le Ferrec E., and Guillouzo A. The human glutathione transferase alpha locus: Genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter Pharmacogenetics 12 2002 277 286
13. Payne A.H., and Hales D.B. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones Endocr. Rev. 25 2004 947 970
14. 5-androstene- 3,17-dione catalyzed by human glutathione transferase A1-1 J. Biol. Chem. 276 2001 11698 11704
15. Pettersson P.L., Johansson A.-S., and Mannervik B. Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase J. Biol. Chem. 277 2002 30019 30022
16. Rabahi F., Brule S., Sirois J., Beckers J.F., Silversides D.W., and Lussier J.G. High expression of bovine alpha glutathione S-transferase (GSTA1, GSTA2) subunits is mainly associated with steroidogenically active cells and regulated by gonadotropins in bovine ovarian follicles Endocrinology 140 1999 3507 3517
17. Simons P.C., and Vander Jagt D.L. Purification of glutathione S-transferases by glutathione-affinity chromatography Methods Enzymol. 77 1981 235 237
18. Suzuki T., Johnston P.N., and Board P.G. Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes Genomics 18 1993 680 686
19. Tiltman A.J., and Haffajee Z. Distribution of glutathione S-transferases in the human ovary: An immunohistochemical study Gynecol. Obstet. Invest. 47 1999 247 250
20. Wang C., Bammler T.K., and Eaton D.L. Complementary DNA cloning, protein expression, and characterization of Alpha-class GSTs from Macaca fascicularis liver Toxicol. Sci. 70 2002 20 26