Determination of solute lipophilicity by reversed-phase high-performance liquid chromatography (RP-HPLC)

Journal of Medical Investigation

Volumn 52, Issue SUPPL., 2005, Pages 293-294

  Liu, Xiangli ^a   Chuman, Hiroshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

LC; Lipophilicity; Log Kw; Log Poct

Indexed keywords

XENOBIOTIC AGENT;

CHROMATOGRAPHY; CONFERENCE PAPER; DRUG ABSORPTION; DRUG ELIMINATION; DRUG METABOLISM; LIPOPHILICITY; PARTITION COEFFICIENT; PHARMACODYNAMICS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLVATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIPIDS; OCTANOLS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 30144435333     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: 10.2152/jmi.52.293     Document Type: Conference Paper

References (3)

1. Lambert WJ: Modeling oil-water partitioning and membrane permeation using reversed-phase chromatography. J Chromatogr 656: 469-484, 1993.
2. Van der Waterbeemed H, Kansy M, Wagner B, Fischer H: lipophilicity measurement by reversed-phase chromatography. In: Pliska V, Testa B, Van der Waterbeemed H, eds. Lipophilicity in Drug Action and Toxicology. VCH Publishers: Weinheim, 1996, pp.73-87
3. Kalizan R: High performance liquid chromatography methods and procedures of hydrophobicity determination. Quant Struc-Act Relat 9: 83-87, 2003