On the intra-host dynamics of HIV-1 infections

Mathematical Biosciences

Volumn 199, Issue 1, 2006, Pages 1-25

  Stilianakis, Nikolaos I ^a,b   Schenzle, Dieter ^c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JOINT RESEARCH CENTRE   (Italy)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Disease progression; HIV infection; Mathematical model; T cell dynamics

Indexed keywords

IMMUNOLOGY; MATHEMATICAL MODELS; NUMERICAL ANALYSIS; PATHOLOGY; PATIENT TREATMENT; VIRUSES;

DISEASE PROGRESSION; HIV INFECTION; T-CELL DYNAMICS; VIRAL REPRODUCTIVE CAPACITY;

DISEASE CONTROL;

CD4 ANTIGEN;

HOST-PATHOGEN INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS; NUMERICAL MODEL; VIRAL DISEASE;

ARTICLE; CELL POPULATION; DISEASE COURSE; DYNAMICS; HOST RANGE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENCE; INFECTION RATE; LENTIVIRINAE; MATHEMATICAL MODEL; QUALITATIVE ANALYSIS; T LYMPHOCYTE; VIRUS REPLICATION;

ALGORITHMS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; EVOLUTION, MOLECULAR; HIV INFECTIONS; HIV-1; HUMANS; MODELS, BIOLOGICAL; MODELS, THEORETICAL;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS;

EID: 30144434857     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mbs.2005.09.003     Document Type: Article

References (59)

1. G. Pantaleo, C. Graziosi, and A.S. Fauci The immunopathogenesis of human immunodeficiency virus infection N. Engl. J. Med. 328 1993 327
2. J.A. Levy Pathogenesis of human immunodeficiency virus infection Microbiol. Rev. 57 1993 183
3. E.A. Berger, P.M. Murphy, and J.M. Farber Chemokine receptors as HIV-1 coreceptors: role in viral entry, tropism and disease Annu. Rev. Immunol. 17 1999 657
4. A.T. Haase Population biology of HIV-1 infection: viral and CD4 T cell demographics and dynamics in lymphatic tissues Annu. Rev. Immunol. 17 1999 625
5. B. Tindall, and D.A. Cooper Primary HIV infection: host responses and intervention strategies AIDS 5 1991 1
6. E.S. Daar, T. Moudgil, R.D. Meyer, and D.D. Ho Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection N. Engl. J. Med. 324 1991 961
7. R.A. Koup, J.A. Safrit, Y. Cao, C.A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D.D. Ho Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome J. Virol. 68 1994 4650
8. + lymphocytes Science 283 1999 857
9. M. Piatak Jr., M.S. Saag, L.C. Yang, S.J. Clark, J.C. Kappes, K.C. Luk, B.H. Hahn, G.M. Shaw, and J.D. Lifson High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR Science 259 1993 1749
10. M. Harris, P. Patedaude, P. Copperberg, D. Filipenko, A. Thorn, and J. Raboud Correlation of virus load in plasma and lymph node tissue in human immunodeficiency virus infection J. Infect. Dis. 176 1997 1388
11. R.D. Hockett, K.J. Michael, C.A. Derdeyn, M.S. Saag, M. Sillers, K. Squires, S. Chiz, M.A. Nowak, G.M. Shaw, and R.P. Bucy Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA J. Exp. Med. 189 1999 1545
12. J.W. Mellors, C.W. Rinaldo Jr., P. Gupta, R.M. White, J.A. Todd, and L.A. Kingsley Prognosis in HIV-1 infection predicted by the quantity of virus in plasma Science 272 1996 1167
13. + T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals J. Virol. 67 1993 1772
14. T.A. Reinhart, M.J. Rogan, D. Huddleston, D.M. Rausch, L.E. Eiden, and A.T. Haase Simian immunodeficiency virus burden in tissues and cellular compartments during clinical latency and AIDS J. Infect. Dis. 176 1997 1198
15. S.D. Lawn, B.D. Roberts, G.E. Griffin, T.M. Folks, and S.T. Butera Cellular compartments of human immunodeficiency virus type 1 replication in vivo: determination by presence of virion-associated host proteins and impact of opportunistic infection J. Virol. 74 2000 139
16. J.C. Hendriks, G.A. Satten, E.J. Van Ameijden, H.A. van Druten, R.A. Coutinho, and G.J. van Griensven The incubation period to AIDS in injecting drug users estimated from prevalent cohort data, accounting for death prior to an AIDS diagnosis AIDS 12 1998 1537
17. Collaborative Group on AIDS incubation and HIV survival including the CASCADE EU Concerted Action, Time from HIV-1 seroconvertion to AIDS and death before widespread use of highly-active retroviral therapy: a collaborative re-analysis, Lancet, 355 (2000) 1131.
18. D. Morgan, C. Mahe, B. Mayanja, J.M. Okongo, R. Lubega, and J.A.G. Whitworth HIV-1 infection in rural Africa: is there a difference in median time to AIDS nd survival compared with that in industrialized countries? AIDS 16 2002 597
19. S. Jaffar, A.D. Grant, J. Whitworth, P.G. Smith, and H. Whittle The natural history of HIV-1 and HIV-2 infections in adults in Africa: a literature review Bull. World Health Organ. 82 2004 462
20. J.P. Phair Determinants of the natural history of human immunodeficiency virus type 1 infection J. Infect. Dis. 179 Suppl. 2 1999 S384
21. A. Munoz, C.A. Sabin, and A.N. Philips The incubation period of AIDS AIDS 11 Suppl. 1997 S69
22. +-T cell depletion in HIV disease Nature 410 2001 974
23. A.S. Perelson, and P.W. Nelson Mathematical analysis of HIV-1 dynamics in vivo SIAM Rev. 41 1999 3
24. M.A. Nowak, and R.M. May Virus Dynamics 2000 Cambridge University Cambridge, UK
25. R.A. Weiss How does HIV cause AIDS Science 260 1993 1273
26. C. Cheng-Mayer, D. Seto, M. Tateno, and J.A. Levy Biological features of HIV-1 that correlate with virulence in the host Science 240 1988 80
27. E.M. Fenyo, L. Morfeldt-Manson, F. Chiodi, B. Lind, A. von Gegerfelt, J. Albert, E. Olausson, and B. Asjo Distinctive replicative and cytopathic characteristics of human immunodeficiency virus isolates J. Virol. 62 1988 4414
28. M. Tersmette, R.A. Gruters, F. de Wolf, R.E. de Goede, J.M. Lange, P.T. Schellekens, J. Goudsmit, H.G. Huisman, and F. Miedema Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency virus syndrome: studies on sequential HIV isolates J. Virol. 63 1989 2118
29. J.T. Kimata, L. Kuller, D.B. Anderson, P. Dailey, and J. Overbaugh Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression Nat. Med. 5 1999 535
30. A.N. Phillips, A.R. McLean, C. Loveday, M. Tyrer, M. Bofill, H. Devereux, S. Madge, A. Dykoff, A. Drinkwater, A. Burke, L. Huckett, G. Janossy, and M.A. Johnson In vivo HIV-1 replicative capacity in early and advanced infection AIDS 13 1999 67
31. D. Schenzle A model for AIDS pathogenesis Stat. Med. 13 1994 2067
32. N.I. Stilianakis, K. Dietz, and D. Schenzle Analysis of a model for the pathogenesis of AIDS Math. Biosci. 145 1997 27
33. D.D. Ho, A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard, and M. Markowitz Rapid turnover of plasma virons and CD4 lymphocytes Nature 373 1995 123
34. X. Wei, S.K. Ghost, M.E. Taylor, V.A. Johnson, E.A. Emini, P. Deutsch, J.D. Lifson, S. Bonhoeffer, M.A. Nowak, and B.H. Hahn Viral dynamics in human immunodeficiency virus type 1 infection Nature 373 1995 117
35. N.I. Stilianakis, C.A.B. Boucher, M.D. De Jong, R. Van Leeuwen, R. Schuurman, and R.J. De Boer Clinical data sets on human immunodeficiency virus type 1 reverse transcriptase resistant mutants explained by a mathematical model J. Virol. 71 1997 161
36. L.M. Michael Host genetic influences on HIV-1 pathogenesis Curr. Opin. Immunol. 11 1999 466
37. J. Tang, and R.A. Kaslow The impact of host genetics on HIV infection and disease progression in the era of highly activeretroviral therapy AIDS 17 2003 S51
38. A.L. Hughes, and M. Yeager Natural selection at major histocompatibilty complex loci of vertebrates Annu. Rev. Genet. 32 1998 415
39. M. Carrington, G.W. Nelson, M.P. Martin, T. Kissner, D. Vlahov, J.J. Goedert, R. Kaslow, S. Buchbinder, K. Hoots, and S.J. O'Brien HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantages Science 283 1999 1748
40. F. Trepel Number and distribution of lymphocytes in man. A critical analysis Klin. Wschr. 52 1974 511
41. J. Westermann, and R. Pabst Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system? Immunol. Today 11 1990 406
42. J.L. Malone, T.E. Simms, G.C. Gray, K.F. Wagner, J.R. Burger, and D.S. Burke Sources of variability in repeated T-helper lymphocyte counts from human immunodeficiency virus type 1 infected patients: total lymphocyte counts fluctuation and diurnalcycle are important J. Acquired Immune Defic. Syndr. 3 1990 144
43. + T cells depleted? Proc. Natl. Acad. Sci. USA 99 2002 15572
44. + T-cell activation in HIV infection is antigenic stimulation J. Acquired Immune Defic. Syndr. 25 2000 203
45. A.N. Phillips Reduction of HIV concentration during acute infection: independence from a specific immune response Science 271 1996 497
46. S. Bour, R. Geleziunas, and M.A. Wainberg The role of CD4 and its downmodulation in establishment and maintenance of HIV-1 infection Immunol. Rev. 140 1994 147
47. T. Harrer, S. Harrer, S.A. Kalams, T. Elbeik, S.I. Staprans, M.B. Feinberg, Y. Cao, D.D. Ho, T. Yilma, A.M. Caliendo, R.P. Johnson, S.P. Buchbinder, and B.D. Walker Strong cytotoxic T cells and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection AIDS Res. Hum. Retroviruses 12 1996 585
48. H. Mohri, S. Bonhoeffer, S. Monard, A.S. Perelson, and D.D. Ho Rapid turnover of T-lymphocytes in SIV-infected rhesus macaques Science 279 1998 1223
49. A.S. Perelson, A.U. Neumann, M. Markowitz, J.M. Leonard, and D.D. Ho HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time Science 271 1996 1582
50. Centers for Disease Control, 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morb. Motal. Wkly Rep., 41 (1993) RR-17.
51. T.C. Quinn Acute primary HIV infection JAMA 278 1997 58
52. M.T. Niu, D.S. Stein, and S.M. Schnittman Primary HIV type 1 infection: review of pathogenesis and early treatment intervention in humans and animal retrovirus infections J. Infect. Dis. 168 1993 1490
53. + T cells Nature 417 2002 95
54. J. Albert, J. Fiore, E.M. Fenyö, C. Pedersen, J.D. Ludgren, J. Gerstorf, and C. Nielsen Biological phenotype of HIV-1 and transmission AIDS 9 1995 822
55. M.S. Saag, S.M. Hammer, and J.M.A. Lange Pathogenicity and diversity of HIV and implications for clinical management. A review J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 7 1994 S2
56. + T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV-1 infection J. Infect. Dis. 178 1998 1279
57. + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen J. Exp. Med. 187 1998 1295
58. C. Fraser, N.M. Ferguson, F. De Wolf, and R.M. Anderson The role of antigenic stimulation and cytotoxic T cell activity in regulating the long immunopathogenesis of HIV: mechanisms and clinical implications Proc. R. Sci. Lond. B 268 2001 2085
59. G.S. Gottlieb, D.C. Nickle, M.A. Jensen, K.G. Wong, J. Grobler, F. Li, S.-L. Liu, C. Rademeyer, G.H. Learn, S.S. Abdool Karim, C. Williamson, L. Corey, J.B. Margolick, and J.I. Mullins Dual HIV-1 infection associated with disease progression Lancet 363 2004 619