Lack of pharmacokinetic interaction between linezolid and antacid in healthy volunteers

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 1, 2006, Pages 68-72

  Grunder, Gabriela ^a   Zysset Aschmann, Yvonne ^a   Vollenweider, Florence ^a   Maier, Thomas ^b   Krähenbühl, Stephan ^a   Drewe, Juergen ^a  

^a Department of Obstetrics and Gynaecology   (Switzerland)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM MAGNESIUM HYDROXIDE; AMIFLOXACIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTACID AGENT; ANTIBIOTIC AGENT; CEFALEXIN; CEFIXIME; CEFPODOXIME PROXETIL; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; DOXYCYCLINE; FAMOTIDINE; GEMIFLOXACIN; LINEZOLID; NORFLOXACIN; OFLOXACIN; OMEPRAZOLE; PARACETAMOL; PROTON PUMP INHIBITOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE;

ABDOMINAL PAIN; ADULT; ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SIDE EFFECT; URINARY FREQUENCY;

ACETAMIDES; ADMINISTRATION, ORAL; ADULT; ALUMINUM HYDROXIDE; ANTACIDS; AREA UNDER CURVE; CROSS-OVER STUDIES; DRUG COMBINATIONS; DRUG INTERACTIONS; FEMALE; HUMANS; MAGNESIUM HYDROXIDE; MALE; MIDDLE AGED; OXAZOLIDINONES; SEX FACTORS; VOLUNTARY WORKERS;

EID: 29944446669     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.1.68-72.2006     Document Type: Article

References (30)

1. Allen, A., M. Vousden, and A. Lewis. 1999. Effect of omeprazole on the pharmacokinetics of oral gemifloxacin in healthy volunteers. Chemotherapy 45:496-503.
2. Allen, A., M. Vousden, A. Porter, and A. Lewis. 1999. Effect of Maalox on the bioavailability of oral gemifloxacin in healthy volunteers. Chemotherapy 45:504-511.
3. Bernstein, W. B., R. F. Trotta, J. T. Rector, J. A. Tjaden, and A. J. Barile. 2003. Mechanisms for linezolid-induced anemia and thrombocytopenia. Ann. Pharmacother. 37:517-520.
4. 2-blockers and antacids on gastrointestinal absorption. Eur. J. Clin. Microbiol. Infect. Dis. 11:465-468.
5. Burkhardt, O., K. Borner, N. von der Hoh, P. Koppe, M. W. Pletz, C. E. Nord, and H. Lode. 2002. Single- and multiple-dose pharmacokinetics of linezolid and co-amoxiclav in healthy human volunteers. J. Antimicrob. Chemother. 50:707-712.
6. Chin, T. F., and J. L. Lach. 1975. Drug diffusion and bioavailability: tetracycline metallic chelation. Am. J. Hosp. Pharm. 32:625-629.
7. Daly, J. S., G. M. Eliopoulos, E. Reiszner, and R. C. Moellering, Jr. 1988. Activity and mechanism of action of DuP 105 and DuP 721, new oxazolidinone compounds. J. Antimicrob. Chemother. 21:721-730.
8. Daly, J. S., G. M. Eliopoulos, S. Willey, and R. C. Moellering, Jr. 1988. Mechanism of action and in vitro and in vivo activities of S-6123, a new oxazolidinone compound. Antimicrob. Agents Chemother. 32:1341-1346.
9. Deppermann, K. M., H. Lode, G. Hoffken, G. Tschink, C. Kalz, and P. Koeppe. 1989. Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid. Antimicrob. Agents Chemother. 33:1901-1907.
10. Eustice, D. C., P. A. Feldman, I. Zajac, and A. M. Slee. 1988. Mechanism of action of DuP 721: inhibition of an early event during initiation of protein synthesis. Antimicrob. Agents Chemother. 32:1218-1222.
11. Eustice, D. C., P. A. Feldman, and A. M. Slee. 1988. The mechanism of action of DuP 721, a new antibacterial agent: effects on macromolecular synthesis. Biochem. Biophys. Res. Commun. 150:965-971.
12. Flockhart, D. A., Z. Desta, and S. K. Mahal. 2000. Selection of drugs to treat gastro-oesophageal reflux disease: the role of drug interactions. Clin. Pharmacokinet. 39:295-309.
13. Garty, M., and A. Hurwitz. 1980. Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline. Clin. Pharmacol. Ther. 28:203-207.
14. Grasela, T. H., Jr., J. J. Schentag, A. J. Sedman, J. H. Wilton, D. J. Thomas, R. W. Schultz, M. E. Lebsack, and A. W. Kinkel. 1989. Inhibition of enoxacin absorption by antacids or ranitidine. Antimicrob. Agents Chemother. 33:615-617.
15. Gugler, R., and H. Allgayer. 1990. Effects of antacids on the clinical pharmacokinetics of drugs. An update. Clin. Pharmacokinet. 18:210-219.
16. Healy, D. P., J. V. Sahai, L. P. Sterling, and E. M. Racht. 1989. Influence of an antacid containing aluminum and magnesium on the pharmacokinetics of cefixime. Antimicrob. Agents Chemother. 33:1994-1997.
17. Jaffe, J. M., R. I. Poust, S. L. Feld, and J. L. Colaizzi. 1974. Influence of repetitive dosing and altered urinary pH on doxycycline excretion in humans. J. Pharm. Sci. 63:1256-1260.
18. Lode, H. 1988. Drug interactions with quinolones. Rev. Infect. Dis. 10(Suppl. 1):S132-S136.
19. Mizuki, Y., I. Fujiwara, and T. Yamaguchi. 1996. Pharmacokinetic interactions related to the chemical structures of fluoroquinolones. J. Antimicrob. Chemother. 37(Suppl. A):41-55.
20. Neuvonen, P. J. 1976. Interactions with the absorption of tetracyclines. Drugs 11:45-54.
21. Nguyen, V. X., D. E. Nix, S. Gillikin, and J. J. Schentag. 1989. Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline. Antimicrob. Agents Chemother. 33:434-436.
22. 2 receptor antagonist. Antimicrob. Agents Chemother. 36:796-800.
23. Shyu, W. C., R. B. Wilber, K. A. Pittman, and R. H. Barbhaiya. 1992. Effect of antacid on the bioavailability of cefprozil. Antimicrob. Agents Chemother. 36:962-965.
24. Sisson, T. L., G. L. Jungbluth, and N. K. Hopkins. 2002. Age and sex effects on the pharmacokinetics of linezolid. Eur. J. Clin. Pharmacol. 57:793-797.
25. Smith, P. F., M. C. Birmingham, G. A. Noskin, A. K. Meagher, A. Forrest, C. R. Rayner, and J. J. Schentag. 2003. Safety, efficacy and pharmacokinetics of linezolid for treatment of resistant gram-positive infections in cancer patients with neutropenia. Ann. Oncol. 14:795-801.
26. Sommers, D. K., M. Van Wyk, P. E. Williams, and S. M. Harding. 1984. Pharmacokinetics and tolerance of cefuroxime axetil in volunteers during repeated dosing. Antimicrob. Agents Chemother. 25:344-347.
27. Staniforth, D. H., H. L. Clarke, R. Horton, D. Jackson, and D. Lau. 1985. Augmentin bioavailability following cimetidine, aluminum hydroxide and milk. Int. J. Clin. Pharmacol. Ther. Toxicol. 23:154-157.
28. Stroshane, R. M., R. R. Brown, J. A. Cook, and P. S. Wissel. 1989. Effect of food, milk and antacid on the absorption of orally administered amifloxacin. Rev. Infect. Dis. 11(Suppl. 5):S1018-S1019.
29. Tartarone, A., G. Gallucci, G. Iodice, G. Romano, M. Coccaro, M. L. Vigliotti, G. Mele, R. Matera, and N. Di Renzo. 2004. Linezolid-induced bradycardia: a case report. Int. J. Antimicrob. Agents 23:412-413.
30. Tobin, C. M., J. Sunderland, L. O. White, and A. P. MacGowan. 2001. A simple, isocratic high-performance liquid chromatography assay for linezolid in human serum. J. Antimicrob. Chemother. 48:605-608.