Erybraedin C and bitucarpin A, two structurally related pterocarpans purified from Bituminaria bituminosa, induced apoptosis in human colon adenocarcinoma cell lines MMR- and p53-proficient and -deficient in a dose-, time-, and structure-dependent fashion

Chemico-Biological Interactions

Volumn 159, Issue 2, 2006, Pages 104-116

  Maurich, Tiziana ^a   Iorio, Mariacarla ^b   Chimenti, Daniele ^c   Turchi, Gino ^a  

^a CNR   (Italy)

^b CISANELLO HOSPITAL   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

Apoptosis; Cell cycle; Cell density; Isoflavonoid pterocarpans; Topoisomerase II

Indexed keywords

BITUCARPIN A; DNA TOPOISOMERASE (ATP HYDROLYSING); ERYBRAEDIN C; ETOPOSIDE; ISOFLAVONOID; PLANT EXTRACT; PROTEIN BCL 2; PROTEIN P53; PTEROCARPAN DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BITUMINARIA BITUMINOSA; CANCER; CELL CYCLE ARREST; CELL DEATH; CELL GROWTH; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DNA DETERMINATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEGUME; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; FABACEAE; HUMANS; PTEROCARPANS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOGUANINE; TUMOR SUPPRESSOR PROTEIN P53;

BITUMINARIA BITUMINOSA;

EID: 29944441487     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.103     Document Type: Article

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