A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to bacille Calmette-Guérin (BCG) immunisation [ISRCTN32849447]

BMC Infectious Diseases

Volumn 5, Issue , 2005, Pages

  Elliott, Alison M ^a,e   Namujju, Proscovia B ^a   Mawa, Patrice A ^a   Quigley, Maria A ^c,e   Nampijja, Margaret ^a   Nkurunziza, Peter M ^a   Belisle, John T ^d   Muwanga, Moses ^b   Whitworth, James A G ^a,e,f  

^a UGANDA VIRUS RESEARCH INSTITUTE   (Uganda)

^b Entebbe Hospital   (Uganda)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Department of Environmental and Radiological Health Sciences   (United States)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; BCG VACCINE; GAMMA INTERFERON; INTERLEUKIN 5; MYCOBACTERIUM ANTIGEN; PLACEBO; BACTERIAL ANTIGEN;

ANTIGEN DETECTION; ARTICLE; BCG VACCINATION; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG RESPONSE; FEMALE; HOOKWORM INFECTION; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; INFANT; INTERFERON PRODUCTION; LOGISTIC REGRESSION ANALYSIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; SECOND TRIMESTER PREGNANCY; SINGLE DRUG DOSE; UGANDA; ADULT; ANIMAL; HELMINTH; IMMUNOLOGY; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; PREGNANCY; PREGNANCY COMPLICATION;

ADULT; ALBENDAZOLE; ANIMALS; ANTIGENS, BACTERIAL; BCG VACCINE; DOUBLE-BLIND METHOD; FEMALE; HELMINTHS; HOOKWORM INFECTIONS; HUMANS; INFANT; INTERFERON-GAMMA; MYCOBACTERIUM TUBERCULOSIS; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC;

EID: 29944432795     PISSN: 14712334     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-5-115     Document Type: Article

References (27)

1. Colditz GA, Brewer TF, Berkley CS, Wilson ME, Burdick E, Fineberg HV, Mosteller F. Efficacy of BCG vaccine in the prevention of tuberculosis. JAMA 1994, 271: 698-702.
2. Maizels RM, Yazdanbakhsh M. Immune regulation by helminth parasites: cellular and molecular mechanisms. Nature Reviews in Immunology 2003, 3: 733-744.
3. Bundy D, Sher A, Michael E. Good worms or bad worms: do worm infections affect the epidemiological patterns of other diseases? Parasitology Today 2000, 16: 273-312.
4. Malhotra I, Mungai P, Wamachi A, Kioko J, Ouma JH, Kazura JW, King CL. Helminth- and Bacillus-Calmette-Guerin-induced immunity in children sensitized in utero to filariasis and schistosomiasis. Journal of Immunology 1999, 162: 6843-6848.
5. Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. New England Journal of Medicine 2004, 49-56.
6. Quinnell RJ, Pritchard DI, Raiko A, Brown AP, Shaw M-A. Immune responses in human necatoriasis: Interleukin-5 responses are associated with resistance to reinfection. Journal of Infectious Diseases 2004, 190: 430-438.
7. Bradley M, Horton J. Assessing the risk of benzimidazole therapy during pregnancy. Transactions of the Royal Society of Tropical Medicine & Hygiene 2001, 95: 72-73.
8. News & Analysis: Soil-transmitted belminthiasis. Nature Reviews in Microbiology 2004, 2: 618-619.
9. Allen HE, Crompton DWT, de Silva N, LoVerde PT, Olds GR. New policies for using anthelminthics in high risk groups. Trends in Parasitology 2002, 18:381-382.
10. Bukusuba JW, Hughes P, Kizza M, Muhangi L, Muwanga M, Whitworth JAG, Elliott AM. Screening for intestinal helminth infection in a semi-urban cohort of pregnant women in Uganda. Tropical Doctor 2004, 34: 27-28.
11. Melrose WD, Turner PF, Pisters P, Turner B. An improved Knott's concentration test for the detection of microfilariae. Transactions of the Royal Society for Tropical Medicine & Hygiene 2000, 94: 176.
12. Elliott AM, Hurst TJ, Baleyku M, Quigley M, Kaleebu P, French N, Biryawaho B, Whitworth JAG, Dockrell HM, Hayes RJ. The immune response to Mycobacterium tuberculosis in HIV infected and uninfected adults: Application of the whole blood cytokine assay in an epidemiological study in Uganda. International Journal of Tuberculosis and Lung Disease 1999, 3: 239-247.
13. Moir M, Holbrook RH. Application of the hemoglobin alkaline denaturation test to determine the fetal origin of blood: applicability to funipuncture. Obstetrics & Gynecology 1993, 81: 793-796.
14. Hall A. Quantitative variability of nematode egg counts in faeces: a study among rural Kenyans. Transaction of the Royal Society of Tropical Medicine and Hygiene 1981, 75: 682-687.
15. Pearlman E, Kazura JW, Hazlett FE, Boom WH. Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses. Journal of Immunology 1993, 151:4857-4864.
16. Erb KJ, Trujillo C, Fugate M, Moll H. Infection with the helminth Nippostrongylus brasiliensis does not interfere with efficient elimination of Mycobacterium bovis BCG from the lungs of mice. Clinical and Diagnostic Laboratory Immunology 2002, 9:727-730.
17. Elias D, Akuffo H, Thors C, Pawlowski A, Britton S. Low dose chronic Schistosoma mansoni infection increases susceptibility to Mycobacterium bovis BCG infection in mice. Clinical and Experimental immunology 2005, 139:398-404.
18. Elias D, Akuffo H, Pawlowski A, Haile M, Schon T, Britton S. Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis. Vaccine 2005, 23:1326-1334.
19. El-Kalouby AH, Amer R, Abdel-Wahab MF, El-Raziky EH. Delayed hypersensitivity to specific antigen and beterologous PPD antigen in patients infected with Schistosoma mansoni and/or Schistosoma haematobium. Egyptian Journal of Bilharzia 1979, 6:43-49.
20. Kilian HD, Nielsen G. Cell mediated and humoral immune responses to BCG and rubella vaccinations and to recall antigens in onchocerciasis patients. Tropical Medicine and Parasitology 1989, 40:445-453.
21. Elkhalifa MY, Ghalib HW, Dafa'alla T, Williams JF. Suppression of human lymphocyte responses to specific and non-specific stimuli in human onchocerciasis. Clinical Experimental immunology 1991, 86:433-439.
22. Pelly TF, Santillan CF, Gilman RH, Cabrera LZ,. Garcia E, Vidal C, Zimic MJ, Moore DAJ, Evans CA. Tuberculosis skin testing, anergy and protein malnutrition in Peru. international Journal of Tuberculosis and Lung Disease 2005, 9:977-984.
23. Rougemont A, Boisson-Pontal ME, Pontal PG, Gridel F. Tuberculin skin tests and BCG vaccination in hyperendemic area of onchocerciasis. Lancet 1977, i: 309.
24. Elias D, Wolday D, Akuffo H, Petros B, Bronner U, Britton S. Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guerin (BCG) vaccination. Clinical Experimental Imnunology 2001, 123:219-225.
25. Power CA, Wei G, Bretscher PA. Mycobacterial dose defines the Th1/Th2 nature of the immune response independently of whether immunization is administered by intravenous, subcutaneous or intradermal route. Infection and Immunity 1998, 66:5743-5750.
26. Gruppo V, Orme IM. Dose of BCG does not influence the efficient generation of protective immunity in mice challenged with Mycobacterium tuberculosis. Tuberculosis 2002, 82: 267-273.
27. Elliott AM, Hodsdon WS, Kyosiimire J, Quigley MA, Nakiyingi JS, Namujju PB, Watera C, French N, Gilks CF, Dockrell HM, Whitworth JAG. Cytokine responses and progression to active tuberculosis in HIV-1 infected Ugandans: a prospective study. Transactions of the Royal Society of Tropical Medicine and Hygiene 2004, 98: 660-670.