Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia

Neurobiology of Aging

Volumn 27, Issue 2, 2006, Pages 285-292

  Engelborghs, Sebastiaan ^a,b   Dermaut, Bart ^c   Mariën, Peter ^a   Symons, Anoek ^a   Vloeberghs, Ellen ^b   Maertens, Karen ^b   Somers, Nore ^a   Goeman, Johan ^a   Rademakers, Rosa ^c   Van Den Broeck, Marleen ^c   Pickut, Barbara ^a   Cruts, Marc ^c   Van Broeckhoven, Christine ^c   De Deyn, Peter P ^a,b  

^a MIDDELHEIM HOSPITAL   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Aggressiveness; Alzheimer's disease; Anxiety; APOE; Behavior; BPSD; Delusions; Dementia; Frontotemporal dementia; Hallucinations; Psychosis

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E EPSILON4; UNCLASSIFIED DRUG;

ADULT; AGED; AGGRESSIVENESS; ALZHEIMER DISEASE; ARTICLE; BEHAVIOR; BLOOD SAMPLING; CLINICAL STUDY; CONTROLLED STUDY; DELUSION; DEMENTIA; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA EXTRACTION; FEMALE; FRONTAL LOBE; FRONTOTEMPORAL DEMENTIA; GENE FREQUENCY; GENOTYPE; HUMAN; LEWY BODY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; RATING SCALE; SCORING SYSTEM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BEHAVIORAL SYMPTOMS; DEMENTIA; DEMOGRAPHY; FEMALE; FRONTAL LOBE; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED;

EID: 29844437091     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2005.02.005     Document Type: Article

References (53)

1. American Psychiatric Association. DSM-IV: diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
2. C. Ballard, H. Massey, H. Lamb, and C. Morris Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease J Neurol Neurosurg Psychiatry 63 1997 273
3. M. Boccardi, F. Sabattoli, C. Testa, A. Beltramello, H. Soininen, and G.B. Frisoni APOE and modulation of Alzheimer's and frontotemporal dementia Neurosci Lett 356 2004 167 170
4. M. Cantillon, D. Harwood, W. Barker, P. St. George-Hyslop, T. Tsuda, and R. Ekatarina No association between apolipoprotein E genotype and late-onset depression in Alzheimer's disease Biol Psychiatry 41 1997 246 248
5. H.C. Chui, J.I. Victoroff, D. Margolin, W. Jagust, R. Shankle, and R. Katzman Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's disease diagnostic and treatment centers Neurology 42 1992 473 480
6. J.L. Cummings, and D. Kaufer Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited Neurology 47 1996 876 883
7. P.P. De Deyn, K. Rabheru, A. Rasmussen, J.P. Bocksberger, P.L. Dautzenberg, and S. Eriksson A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia Neurology 53 1999 946 955
8. P.P. De Deyn, and W.C. Wirshing Scales to assess efficacy and safety of pharmaceutical agents in the treatment of behavioral and psychological symptoms of dementia J Clin Psychiatry 62 Suppl. 21 2001 19 22
9. P.P. De Deyn, J. Goeman, J. Saerens, S. Engelborghs, S. Verstraeten, and P. Mariën The concept memory clinic: historical perspective and objectives P.P. De Deyn E. Thiery R. D'Hooge Memory: Basic concepts, Disorders and Treatment 2003 Acco Leuven 33 44
10. P.P. De Deyn, S. Engelborghs, J. Saerens, J. Goeman, P. Mariën, and K. Maertens The Middelheim frontality score: a behavioural assessment scale that discriminates frontotemporal dementia from Alzheimer's disease Int J Geriatr Psychiatry 20 2005 70 79
11. R. de la Fuente-Fernandez, M.A. Nunez, and E. Lopez The apolipoprotein E epsilon 4 allele increases the risk of drug-induced hallucinations in Parkinson's disease Clin Neuropharmacol 23 2000 230 231
12. S. Engelborghs, B. Dermaut, J. Goeman, J. Saerens, P. Mariën, and B.A. Pickut A prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects J Neurol Neurosurg Psychiatry 74 2003 1148 1151
13. S. Engelborghs, E. Vloeberghs, K. Maertens, B. Marescau, and P.P. De Deyn Evidence for an association between the CSF HVA:5-HIAA ratio and aggressiveness in patients with frontotemporal dementia but not in Alzheimer's disease J Neurol Neurosurg Psychiatry 75 2004 1080
14. L.A. Farrer, C.R. Abraham, L. Volicer, E.J. Foley, N.W. Kowall, and A.C. McKee Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease Exp Neurol 136 1995 162 170
15. M. Folstein, S. Folstein, and P.R. McHugh Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 196
16. Y. Forsell, H. Basun, E.H. Corder, L. Lannfelt, and B. Winblad Psychotic symptoms and apolipoprotein E genotypes in an elderly population Biol Psychiatry 44 1998 139 140
17. T. Gabryelewicz, D. Religa, M. Styczynska, B. Peplonska, A. Pfeffer, and B. Wasiak Behavioural pathology in Alzheimer's disease with special reference to apolipoprotein E genotype Dement Geriatr Cogn Disord 14 2002 208 212
18. B.S. Harhangi, M.C. de Rijk, C.M. van Duijn, C. Van Broeckhoven, A. Hofman, and M.M. Breteler APOE and the risk of PD with or without dementia in a population-based study Neurology 54 2000 1272 1276
19. C.R. Harrington, J. Louwagie, R. Rossau, E. Vanmechelen, R.H. Perry, and E.K. Perry Influence of apoliprotein E genotype on senile dementia of the Alzheimer and Lewy body types Am J Pathol 145 1994 1472 1484
20. D.G. Harwood, W.W. Barker, R.L. Ownby, P. St George-Hyslop, and R. Duara Apolipoprotein-E genotype and symptoms of psychosis in Alzheimer's disease Am J Geriatr Psychiatry 7 1999 119 123
21. N. Hirono, E. Mori, M. Yasuda, Y. Ikejiri, T. Imamura, and T. Shimomura Factors associated with psychotic symptoms in Alzheimer's disease J Neurol Neurosurg Psychiatry 64 1998 648 652
22. N. Hirono, E. Mori, M. Yasuda, T. Imamura, T. Shimomura, and M. Hashimoto Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease J Neuropsychiatry Clin Neurosci 11 1999 66 70
23. M.M. Hoehn, and M.D. Yahr Parkinsonism: onset, progression and mortality Neurology 17 1967 427 442
24. C. Holmes, C. Russ, G. Kirov, K.J. Aitchison, J.F. Powell, and D.A. Collier Apolipoprotein E: depressive illness, depressive symptoms, and Alzheimer's disease Biol Psychiatry 43 1998 159 164
25. T. Hope, J. Keene, C. Fairburn, R. McShane, and R. Jacoby Behaviour changes in dementia. 2: Are there behavioural syndromes? Int J Geriatr Psychiatry 12 1997 1074 1078
26. R. Inzelberg, J. Chapman, T.A. Treves, T.A. Asherov, S. Kipervasser, and O. Hilkewicz Apolipoprotein E4 in Parkinson's disease and dementia: new data and meta-analysis of published studies Alzheimer Dis Assoc Disord 12 1998 45 48
27. M.L. Levy, J.L. Cummings, L.A. Fairbanks, D.L. Sultzer, G.W. Small, and Apolipoprotein E genotype and noncognitive symptoms in Alzheimer's disease Biol Psychiatry 45 1999 422 425
28. O.L. Lopez, M.I. Kamboh, J.T. Becker, D.I. Kaufer, and S.T. DeKosky The apolipoprotein E epsilon 4 allele is not associated with psychiatric symptoms or extrapyramidal signs in probable Alzheimer's disease Neurology 49 1997 794 797
29. C.G. Lyketsos, L. Baker, A. Warren, C. Steele, J. Brandt, and M. Steinberg Depression, delusions and hallucinations in Alzheimer's disease: no relationship to apolipoprotein E genotype J Neuropsychiatry Clin Neurosci 9 1997 64 67
30. K. Marder, G. Maestre, L. Cote, H. Mejia, B. Alfaro, and A. Halim The apolipoprotein epsilon 4 allele in Parkinson's disease with and without dementia Neurology 44 1994 1330 1331
31. I.G. McKeith, D. Galasko, K. Kosaka, E.K. Perry, D.W. Dickson, and L.A. Hansen Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report on the consortium on DLB International Workshop Neurology 47 1996 1113 1124
32. I.G. McKeith Dementia with Lewy bodies Br J Psychiatry 180 2002 144 147
33. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease Neurology 34 1984 939 944
34. L. Minthon, C. Hesse, M. Sjogren, E. Englund, L. Gustafson, and K. Blennow The apolipoprotein epsilon4 allele frequency is normal in frontotemporal dementia but correlates with age at onset of disease Neurosci Lett 226 1997 65 67
35. M. Moran, C. Walsh, A. Lynch, R.F. Coen, D. Coakley, and B.A. Lawlor Syndromes of behavioural and psychological symptoms in mild Alzheimer's disease Int J Geriatr Psychiatry 19 2004 359 364
36. G.M. Murphy, J. Taylor, J.R. Tinklenberg, and J.A. Yesavage The apolipoprotein E epsilon 4 allele is associated with increased behavioural disturbance in Alzheimer's disease Am J Geriatr Psychiatry 5 1997 88 89
37. D. Neary, J.S. Snowden, L. Gustafson, U. Passant, D. Stuss, and S. Black Frontotemporal lobar degeneration. A consensus on clinical diagnostic criteria Neurology 51 1998 1546 1554
38. B.A. Pickut, J. Saerens, P. Mariën, F. Borggreve, J. Goeman, and J. Vandevivere Discriminative use of SPECT in frontal lobe-type dementia versus (senile) dementia of the Alzheimer's type J Nucl Med 38 1997 929 934
39. T. Polvikoski, R. Sulkava, M. Haltia, K. Kainulainen, A. Vuorio, and A. Verkkoniemi Apolipoprotein E, dementia and cortical deposition of beta-amyloid protein N Engl J Med 333 1995 1242 1247
40. G. Ramachandran, K. Marder, M. Tang, P.W. Schofield, M.R. Chun, and D.P. Devanand A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease Neurology 47 1996 256 259
41. E. Ratnavalli, C. Brayne, K. Dawson, and J.R. Hodges The prevalence of frontotemporal dementia Neurology 58 2002 1615 1621
42. B. Reisberg, S.H. Ferris, M.J. de Leon, and T. Crook The Global Deterioration Scale (GDS) for assessment of primary degenerative dementia Am J Psychiatry 139 1982 1136 1139
43. B. Reisberg, J. Borenstein, S.P. Salob, S.H. Ferris, E. Franssen, and A. Georgotas Behavioral symptoms in Alzheimer's disease: phenomenology and treatment J Clin Psychiatry 48 Suppl 5 1987 9 15
44. G.C. Román, T.K. Tatemichi, T. Erkinjuntti, J.L. Cummings, J.C. Masdeu, and J.H. Garcia Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop Neurology 43 1993 250 260
45. S.M. Rosso, G. Roks, M. Cruts, C. van Broeckhoven, P. Heurink, and C.M. van Duijn Apolipoprotein E4 in the temporal variant of frontotemporal dementia J Neurol Neurosurg Psychiatry 72 2002 820
46. N. Scarmeas, J. Brandt, M. Albert, D.P. Devanand, K. Marder, and K. Bell Association between the APOE genotype and psychopathologic symptoms in Alzheimer's disease Neurology 58 2002 1182 1188
47. A.B. Singleton, A. Wharton, K.K. O'Brien, M.P. Walker, I.G. McKeith, and C.G. Ballard Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies Dement Geriatr Cogn Disord 14 2002 167 175
48. A.J. Slooter, M. Cruts, S. Kalmijn, A. Hofman, M.M. Breteler, and C. Van Broeckhoven Risk estimates of dementia by apolipoprotein E genotyopes from a population-based incidence study: the Rotterdam Study Arch Neurol 55 1998 964 968
49. H. Soderstrom, K. Blennow, A-K. Sjodin, and A. Forsman New evidence for an association between the CSF HVA:5-HIAA ratio and psychopathic traits J Neurol Neurosurg Psychiatry 74 2003 918 921
50. H. Soininen, O. Kosunen, S. Helisalmi, A. Mannermaa, L. Paljarvi, and S. Talasniemi A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele Neurosci Lett 187 1995 79 82
51. M. Stevens, C.M. van Duijn, P. de Knijff, C. Van Broeckhoven, P. Heutink, and B.A. Oostra Apolipoprotein E gene and sporadic frontal lobe dementia Neurology 48 1997 1526 1529
52. W.J. Strittmatter, K.H. Weisgraber, D.Y. Huang, L-M. Dong, G.S. Salvesen, and M. Pericak-Vance Binding of human apolipoprotein E to synthetic amyloid β peptide: isoform specific effects and implications for late-onset Alzheimer disease Proc Natl Acad Sci USA 90 1993 8098 8102
53. A.S. Whitehead, S. Bertrandy, F. Finnan, A. Butler, G.D. Smith, and Y. Ben-Shlomo Frequency of the apolipoprotein E epsilon 4 allele in a case-control study of early onset Parkinson's disease J Neurol Neurosurg Psychiatry 61 1996 347 351