Changes of bcl-xL and bax mRNA expression following traumatic brain injury in rats

Chinese Journal of Traumatology - English Edition

Volumn 5, Issue 5, 2002, Pages 299-302

  Luo, Chun ^a   Lu, Yicheng ^a   Jiang, Jiyao ^a   Zhu, Cheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Brain injuries; Wounds and injuries

Indexed keywords

DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL XL; BAX PROTEIN, RAT; BCL2L1 PROTEIN, RAT; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL X;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPE; GEL ELECTROPHORESIS; HEMISPHERE; HISTOCHEMISTRY; INJURY SEVERITY; MALE; MOLECULAR MECHANICS; MULTIGENE FAMILY; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN INJURY; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BRAIN INJURIES; DNA FRAGMENTATION; IN SITU NICK-END LABELING; MALE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 29744462725     PISSN: 10081275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Luo C, Zhu C, Jiang JC, et al. Alterations of bcl-2, bcl-x and bax protein expression in area CA3 of rat hippocampus following fluid percussion brain injury. Chin J Traumatol (Eng Ed) 1999;2:101-104.
2. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
3. White E. Death-defying acts: a meeting review on apoptosis. Genes Dev 1993;7:2277-2284.
4. L following fluid percussion brain injury in rats. Acad J Sec Mil Med Univ 2001;22:546-560.
5. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
6. Tilly JL, Hsueh AJ. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. J Cell Physiol 1993;154:519-526.
7. Rink A, Fung KM, Trojanowski JQ, et al. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat. Am J Pathol 1995;147:1575-1583.
8. Ng I, Yeo TT, Tang WY, et al. Apoptosis occurs after cerebral contusions in humans. Neurosurgery 2000;46:949-956.
9. Gillardon F, Lenz C, Waschke KF, et al. Altered expression of Bcl-2, Bcl-x, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. Brain Res Mol Brain Res 1996;40:254-260.
10. Luo C, Zhu C. Molecular investigation in traumatic brain injury. Chin J Traumatol 2000;16:573-575.