Phenylalanine breath test as a method to evaluate hepatic dysfunction in obstructive jaundice

Journal of Surgical Research

Volumn 130, Issue 1, 2006, Pages 119-123

  Aoki, Masaru ^a   Ishii, Yukimoto ^a   Ito, Asuka ^b   Khono, Tadashi ^b   Takayama, Tadatoshi ^a  

^a NIHON UNIVERSITY   (Japan)

^b Frontier Research System   (Japan)

Author keywords

Hepatic function; Liver; Obstructive jaundice; Phenylalanine breath test; Phenylalanine hydroxylase activity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; BILIRUBIN; CARBON 13; CARBON DIOXIDE; GAMMA GLUTAMYLTRANSFERASE; PENTOBARBITAL; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILIRUBIN BLOOD LEVEL; BLOOD ANALYSIS; BLOOD CHEMISTRY; BREATH ANALYSIS; CHEMICAL PARAMETERS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISEASE ASSOCIATION; DISEASE MODEL; ENZYME ACTIVITY; EXPIRED AIR; FEMORAL VEIN; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; LAPAROTOMY; LIVER DYSFUNCTION; MALE; NONHUMAN; OBSTRUCTIVE JAUNDICE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT;

ANIMALS; BODY WEIGHT; BREATH TESTS; CARBON DIOXIDE; CARBON ISOTOPES; JAUNDICE, OBSTRUCTIVE; LIVER; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; ORGAN SIZE; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; RATS; RATS, WISTAR;

EID: 29744461211     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2005.08.015     Document Type: Article

References (22)

1. T.A. Koeppel, M. Trauner, J.C. Baas Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver Hepatology 26 1997 1085
2. A. Pastor, P.S. Collado, M. Almer Microsomal function in biliary obstructed rats effects of S-adenosylmethionine J. Hepatol. 24 1996 353 doi:10.1016/S0168-8278(96)80016-X
3. S.M. Sheen-Chen, P. Chau, H.W. Harris Obstructive jaundice alters kupffer cell function independent of bacterial translocation J. Surg. Res. 80 1998 205 doi:10.1006/jsre.1998.5467
4. S. Plusa, N. Webster, J. Primrose Obstructive jaundice causes reduced expression of polymorphonuclear leukocyte adhesion molecules and depressed response to bacterial wall products in vitro Gut 38 1996 784
5. T. Kimura, S. Nakayama, T. Yamao Pharamacokinetics of indocyanine green in rats with experimentally induced hepatic disease Biol. Pharm. Bull. 16 1993 1140
6. S.T. Fan, Q.S. Wang, C.M. Lo Evaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstruction Aust. NZ J. Surg. 64 1994 759
7. M.E. Sewnath, T.M. Karsten, M.H. Prins A meta-analysis on the efficacy of preoperative biliary drainage for tumors causing obstructive jaundice Ann. Surg. 236 2002 17
8. T. Mimura, K. Hamazaki, H. Sakai Evaluation of hepatic functional reserve in rats with obstructive jaundice by asyaloglycoprotein receptor Hepatogastroenterology 48 2001 777
9. H. Zimmermann, H. Blaser, A. Zimmermann Effect of development on the functional and histological changes induced by bile-duct ligation in the rat J. Hepatol. 20 1994 231
10. 13C] phenylalanine breath test reflects histological changes in the liver J. Surg. Res. 114 2003 120 doi:10.1016/S0022-4804(03)00278-6
11. 13C] phenylalanine breath test reflects phenylalanine hydroxylase activity of the whole liver J. Surg. Res. 112 2003 38 doi:10.1016/S0022-4804(03)00135-5
12. 13C] phenylalanine breath test Surgery 132 2002 849
13. 13C] phenylalanine breath test reflects hepatopathy J. Surg. Res. 86 1999 130 doi:10.1006/jsre.1999.5705
14. M. Heberer, H. Talke, K.P. Maier Metabolism of phenylalanine in liver disease Klin. Wochenschr. 58 1980 1189
15. 13C]-phenylalanine breath test and phenylalanine hydroxylase (EC 1.14.16.1) activity of the liver in rats Digestion 63 2001 130
16. H. Freund, J.H. James, W. Brenner Plasma amino acid analysis in the differential diagnosis of jaundice Am. J. Surg. 139 1980 142 doi:10.1016/0002-9610(80)90243-3
17. J.A. Gall, P.S. Bhathal A quantitative analysis of the liver following ligation of the common bile duct Liver 10 1990 116
18. S. Krahenbuhl, U. Marti, I. Grant Characterization of mechanisms causing hypoalbuminemia in rats with long-term bile duct ligation J. Hepatol. 23 1995 79
19. 13C] Phenylalanine oxidation as a measure of hepatocyte functional capacity in end-stage liver disease Am. J. Surg. 173 1997 270 doi:10.1016/S0002-9610(96)00392-3
20. I. Tugtekin, U. Wachter, E. Barth Phenylalanine kinetics in healthy volunteers and liver cirrhotics implications for the phenylalanine breath test Am. J. Physiol. Endocrinol. Metab. 283 2002 1223
21. T. Kobayashi, H. Imamura, T. Takayama The role of preoperative phenylalanine breath test in hepatectomy Hepatogastroenterology 50 2003 1124
22. 13C] phenylalanine breath test Eur. J. Clin. Invest. 31 2001 356