Mosapride improves food intake, while not worsening glycemic control and obesity, in ob/ob obese mice with decreased gastric emptying

Journal of Diabetes and its Complications

Volumn 20, Issue 1, 2006, Pages 56-58

  Asakawa, Akihiro ^a   Ueno, Naohiko ^b   Katagi, Miwako ^a   Ijuin, Yuka ^a   Morita, Yoshinori ^a   Mizuno, Shigeto ^a   Inui, Toshio ^a   Sakamaki, Ruka ^c   Shinfuku, Naotaka ^c   Uemoto, Msaharu ^d  

^a Inui Clinic   (Japan)

^b Kobe Kaigan Hospital   (Japan)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KOBE CITY COLLEGE OF NURSING   (Japan)

Author keywords

5 HT4 receptor; Diabetes mellitus; Food intake; Mosapride citrate; Ob ob mouse

Indexed keywords

FRUCTOSAMINE; GLUCOSE; INSULIN; MOSAPRIDE CITRATE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; FEEDING BEHAVIOR; FLUID INTAKE; FOOD INTAKE; FRUCTOSAMINE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; STOMACH EMPTYING;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; BLOOD GLUCOSE; BODY WEIGHT; EATING; FRUCTOSAMINE; GASTRIC EMPTYING; GASTROINTESTINAL AGENTS; INSULIN; MALE; MICE; MICE, OBESE; MORPHOLINES;

EID: 29744459924     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2005.04.001     Document Type: Article

References (21)

1. A. Asakawa, A. Inui, N. Ueno, S. Makino, M. Uemoto, M.A. Fujino, and M. Kasuga Ob/ob mice as a model of delayed gastric emptying Journal of Diabetes and its Complications 17 2003 27 28
2. H. Asakawa, I. Hayashi, T. Fukui, and K. Tokunaga Effect of mosapride on glycemic control and gastric emptying in type 2 diabetes mellitus patients with gastropathy Diabetes Research and Clinical Practice 61 2003 175 182
3. J.M. Di Diego, L. Belardinelli, and C. Antzelevitch Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation Circulation 108 2003 1027 1033
4. J.P. Duggan, and D.A. Booth Obesity, overeating, and rapid gastric emptying in rats with ventromedial hypothalamic lesions Science 231 1986 609 611
5. A. Inui Transgenic approach to the study of body weight regulation Pharmacological Reviews 52 2000 35 61
6. A. Inui Cancer anorexia-cachexia syndrome: Current issues in research and management CA: A Cancer Journal for Clinicians 52 2002 72 91
7. T. Ishiguchi, H. Tada, K. Nakagawa, T. Yamamura, and T. Takahashi Hyperglycemia impairs antro-pyloric coordination and delays gastric emptying in conscious rats Autonomic Neuroscience 95 2002 112 120
8. T. Kanaizumi, H. Nakano, Y. Matsui, H. Ishikawa, R. Shimizu, S. Park, and N. Kuriya Prokinetic effect of AS-4370 on gastric emptying in healthy adults European Journal of Clinical Pharmacology 41 1991 335 337
9. H. King, R.E. Aubert, and W.H. Herman Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections Diabetes Care 21 1998 1414 1431
10. M.C. Kockar, I.K. Kayahan, and N. Bavbek Diabetic gastroparesis in association with autonomic neuropathy and microvasculopathy Acta Medica Okayama 56 2002 237 243
11. M.F. Kong, M. Horowitz, K.L. Jones, J.M. Wishart, and P.E. Harding Natural history of diabetic gastroparesis Diabetes Care 22 1999 503 507
12. Y. Sakurai-Yamashita, K. Takada, K. Takemura, K. Yamashita, A. Enjoji, T. Kanematsu, and K. Taniyama Ability of mosapride to bind to 5-HT4 receptor in the human stomach Japanese Journal of Pharmacology 79 1999 493 496
13. G.J. Sanger, and L.M. Gaster 5-HT4 receptor antagonists Expert Opinion on Therapeutic Patents 4 1994 323 334
14. G. Stacher Diabetes mellitus and the stomach Diabetologia 44 2001 1080 1093
15. N. Ueno, A. Inui, A. Asakawa, F. Takao, Y. Komatsu, K. Kotani, R. Nishimura, and M. Kasuga Mosapride, a 5HT-4 receptor agonist, improves insulin sensitivity and glycaemic control in patients with Type II diabetes mellitus Diabetologia 45 2002 792 797
16. G.N. Verne, and C.A. Sninsky Diabetes and the gastrointestinal tract Gastroenterology Clinics of North America 27 1998 861 874
17. N. Yoshida Pharmacological effects of the gastroprokinetic agent mosapride citrate Nippon Yakurigaku Zasshi 113 1999 299 307
18. N. Yoshida, H. Omoya, M. Oka, K. Furukawa, T. Ito, and T. Karasawa AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties Archives of International Pharmacodynamics and Therapy 300 1989 51 67
19. N. Yoshida, T. Ito, T. Karasawa, and Z. Itoh AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs The Journal of Pharmacology and Experimental Therapeutics 257 1991 781 787
20. N. Yoshida, S. Kato, and T. Ito Mosapride citrate Drugs Future 18 1993 513 515
21. P. Zimmet, K.G. Alberti, and J. Shaw Global and societal implications of the diabetes epidemic Nature 414 2001 782 787