Laryngeal epithelial defenses against laryngopharyngeal reflux: Investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin

Annals of Otology, Rhinology and Laryngology

Volumn 114, Issue 12 I, 2005, Pages 913-921

  Gill, Gulnaz A ^a   Johnston, Nikki ^c   Buda, Andrea ^a   Pignatelli, Massimo ^a   Pearson, Jeffrey ^b   Dettmar, Peter W ^c   Koufman, Jamie ^c,d  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d Ctr Voice Swallowing Disord W   (United States)

Author keywords

Carbonic anhydrase; Cell biology; Cellular defense; E cadherin; Laryngopharyngeal reflux; Pepsin

Indexed keywords

CARBONATE DEHYDRATASE III; PEPSIN A; UVOMORULIN;

ADULT; AGED; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNGEAL BIOPSY; LARYNGOPHARYNGEAL REFLUX; LARYNX MUCOSA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOCAL CORD; WESTERN BLOTTING;

EID: 29744443713     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940511401204     Document Type: Conference Paper

References (39)

1. Koufman JA. Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J 2002;81(suppl 2):7-9.
2. Orlando RC. Pathogenesis of gastroesophageal reflux disease. Am J Med Sci 2003;326:274-8.
3. Hicks DM, Ours TM, Abelson TI, Vaezi MF, Richter JE. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice 2002;16:564-79.
4. Lanas A, Royo Y, Ortego J, Molina M, Sainz R. Experimental esophagitis induced by acid and pepsin in rabbits mimicking human reflux esophagitis. Gastroenterolology 1999;116:97-107.
5. Tobey NA, Koves G, Orlando RC. HCl-induced cell edema in primary cultured rabbit esophageal epithelium. Gastroenterology 1997;112:847-54.
6. Lanas AI, Sousa FL, Ortego J, et al. Aspirin renders the oesophageal mucosa more permeable to acid and pepsin. Eur J Gastroenterol Hepatol 1995;7:1065-72.
7. Schweitzer EJ, Bass BL, Johnson LF, Harmon JW. Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterology 1985;88:611-9.
8. Tay HP, Chaparala RC, Harmon JW, et al. Bismuth subsalicylate reduces peptic injury of the oesophagus in rabbits. Gut 1990;31:11-6.
9. Hopwood D. Oesophageal damage and defence in reflux oesophagitis: pathophysiological and cell biological mechanisms. Prog Histochem Cytochem 1997;32:1-42.
10. Orlando RC. Gastroesophageal reflux disease: offensive factors and tissue resistance. New York, NY: Dekker, 2000.
11. Goldstein JL, Watkins JL, Greager JA, Layden TJ. The esophageal mucosal resistance: structure and function of an unique gastrointestinal epithelial barrier. J Lab Clin Med 1994;123:653-9.
12. Tobey NA, Carson JL, Alkiek RA, Orlando RC. Dilated intercellular spaces: a morphological feature of acid reflux-damaged human esophageal epithelium. Gastroenterology 1996;111:1200-5.
13. Orlando RC. Esophageal epithelial defenses against acid injury. Am J Gastroenterol 1994;89(suppl):S48-S52.
14. Johnston N, Bulmer D, Gill GA, et al. Cell biology of laryngeal epithelial defenses in health and disease: further studies. Ann Otol Rhinol Laryngol 2003;112:481-91.
15. Tobey NA, Hosseini SS, Caymaz-Bor C, Wyatt HR, Orlando GS, Orlando RC. The role of pepsin in acid injury to esophageal epithelium. Am J Gastroenterol 2001;96:3062-70.
16. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101 (suppl 53).
17. Postma GN, Tomek MS, Belafsky PC, Koufman JA. Esophageal motor function in laryngopharyngeal reflux is superior to that in classic gastroesophageal reflux disease. Ann Otol Rhinol Laryngol 2001;110:1114-6.
18. Bell NJ, Hunt RH. Role of gastric acid suppression in the treatment of gastro-oesophageal reflux disease. Gut 1992;33:118-24.
19. Bremner RM, Crookes PF, DeMeester TR, Peters JH, Stein HJ. Concentration of refluxed acid and esophageal mucosal injury. Am J Surg 1992;164:522-7.
20. Farrow DC, Vaughan TL, Sweeney C, et al. Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer. Cancer Causes Control 2000;11:231-8.
21. Kahrilas PJ, Hogan WJ. Gastroesophageal reflux disease. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal diseases. Vol 1. Philadelphia, Pa: Saunders, 1993:378-401.
22. Ismail-Beigi F, Horton PF, Pope CE II. Histological consequences of gastroesophageal reflux in man. Gastroenterology 1970;58:163-74.
23. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991;251:1451-5.
24. Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995;7:619-27.
25. Smith MEF, Pignatelli M. The molecular histology of neoplasia: the role of the cadherin/catenin complex. Histopathology 1997;31:107-11.
26. Gumbiner BM. Regulation of cadherin adhesive activity. J Cell Biol 2000;148:399-404.
27. Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996;84:345-57.
28. Salo JA, Lehto VP, Kivilaakso E. Morphological alterations in experimental esophagitis. Light microscopic and scanning and transmission electron microscopic study. Dig Dis Sci 1983;28:440-8.
29. Shimono M, Clementi F. Intercellular junctions of oral epithelium. II. Ultrastructural changes in rat buccal epithelium induced by trypsin digestion. J Ultrastruct Res 1977;59:101-12.
30. Axford SE, Sharp N, Ross PE, et al. Cell biology of laryngeal epithelial defenses in health and disease: preliminary studies. Ann Otol Rhinol Laryngol 2001;110:1099-108.
31. Tashian RE. The carbonic anhydrases: widening perspectives on their evolution, expression and function. Bioessays 1989;10:186-92.
32. Sly WS, Hu PY. Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem 1995;64:375-401.
33. Parkkila S, Parkkila AK. Carbonic anhydrase in the alimentary tract. Roles of the different isozymes and salivary factors in the maintenance of optimal conditions in the gastrointestinal canal. Scand J Gastroenterol 1996;31:305-17.
34. Christie KN, Thomson C, Xue L, Lucocq JM, Hopwood D. Carbonic anhydrase isoenzymes I, II, III, and IV are present in human esophageal epithelium. J Histochem Cytochem 1997;45:35-40.
35. Tobey NA, Powell DW, Schreiner VJ, Orlando RC. Serosal bicarbonate protects against acid injury to rabbit esophagus. Gastroenterology 1989;96:1466-77.
36. Helm JF, Dodds WJ, Hogan WJ, Soergel KH, Egide MS, Wood CM. Acid neutralizing capacity of human saliva. Gastroenterology 1982;83:69-74.
37. Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16:274-7.
38. Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001;111:1313-7.
39. Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 2004;114:2129-34.