Dihydroartemisinin inhibits the expression of vascular endothelial growth factor in K562 cells

Yaoxue Xuebao

Volumn 40, Issue 11, 2005, Pages 1041-1045

  Li, Jun ^a   Zhou, Hui Jun ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Angiogenesis; Antitumor activity; Dihydroartemisinin; K562 cells; Vascular endothelial growth factor

Indexed keywords

ANTINEOPLASTIC AGENT; ARTEMISININ DERIVATIVE; DIHYDROARTEMISININ; DIHYDROQUINGHAOSU; MESSENGER RNA; SESQUITERPENE; VASCULOTROPIN A;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL PROLIFERATION; CELL STRAIN K 562; CHICKEN; CHORIOALLANTOIS; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARTEMISININS; CELL PROLIFERATION; CHICKENS; CHORIOALLANTOIC MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; K562 CELLS; NEOVASCULARIZATION, PATHOLOGIC; RNA, MESSENGER; SESQUITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 29744435949     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Keyhani A, Jendiroba DB, Freireich EJ. Angiogenesis and leukemia [J]. Leuk Res, 2001,25(8):639-645.
2. Aguayo A, Giles F, Albitar M. Vascularity, angiogenesis and angiogenic factors in leukemias and myelodysplastic syndromes [J]. Leuk Lymphoma, 2003,44(2):213-222.
3. Bellamy WT, Richter L, Frutiger Y, et al. Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies [J]. Cancer Res, 1999,59 (3):728-733.
4. Aguayo A, Kantarjian H, Manshouri T, et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes [J]. Blood, 2000,96(6): 2240-2245.
5. Efferth T, Dunstan H, Sauerbrey A, et al. The anti-malarial artesunate is also active against cancer [J]. Int J Oncol, 2001,18(4):767-773.
6. Moore JC, Lai H, Li JR, et al. Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat [J]. Cancer Lett, 1995,98 (1):83-87.
7. Chen HH, Zhou HJ. Inhibitory effects of artesunate on angiogenesis [J]. Acta Pharm Sin, 2004, 39(1):29-33.
8. Kini AR, Peterson LA, Tallman MS, et al. Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid [J]. Blood, 2001,97(12):3919-3924.
9. Vacca A, Ribatti D, Iurlaro M, et al. Human lymphoblastoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, and angiogenesis [J]. Int J Clin Lab Res, 1998,28(1):55-68.
10. Aguayo A, Estey E, Kantarjian H, et al. Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia [J]. Blood, 1999,94(11):3717-3721.
11. Roboz GJ, Dias S, Lam G, et al. Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis [J]. Blood, 2000,96(4): 1525-1530.
12. Tu YY. The development of new antimalarial drugs; qinghaosu and dihydro-qinghaosu [J]. Chin Med J (Engl), 1999,112(11):976-977.
13. Benakis A, Paris M, Loutan L, et al. Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers [J]. Am J Trop Med Hyg, 1997,56 (1):17-23.