Microwave-assisted synthesis of 8-mercapto-3-methyl-7-alkyl xanthines - An improved method

Tetrahedron Letters

Volumn 47, Issue 5, 2006, Pages 775-778

  Zhang, Lei ^a   Zhang, Y John ^a  

^a CytRx Laboratories Inc   (United States)

Author keywords

Microwave; Purine; Xanthine

Indexed keywords

8 MERCAPTO 3 METHY 7 ALKYL XANTHINE; ALKYL GROUP; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; METHODOLOGY; MICROWAVE RADIATION; REACTION TIME;

EID: 29644446561     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.11.095     Document Type: Article

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34. 6) ppm. Chemical shifts are given in parts per million and coupling constants, J, are given in hertz. Mass spectra were obtained on Thermo-Finnigan LCQ Advantage MAX spectrometer. Synthesis of 6-amino-5-bromo-1-methyluracil (8 ): To a suspension of 6-amino-1-methyluracil (7.06 g, 50 mmol), sodium bicarbonate (4.2 g, 50 mmol) in methanol (50 mL) was added bromine (2.57 mL, 50 mmol) under vigorous stirring at 0°C during 0.5 h.