Quantitative measurement of deamidation in lens βB2-crystallin and peptides by direct electrospray injection and fragmentation in a Fourier transform mass spectrometer

Molecular Vision

Volumn 11, Issue , 2005, Pages 1211-1219

  Robinson, Noah E ^a   Lampi, Kirsten J ^b   McIver, Robert T ^c   Williams, Robert H ^c   Muster, Wayne C ^c   Kruppa, Gary ^d   Robinson, Arthur B ^a  

^a Oregon Institute of Science and Medicine   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c IonSpec Corporation   (United States)

^d Bruker Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; BETA CRYSTALLIN; GLUTAMIC ACID; GLYCINE; PEPTIDE DERIVATIVE;

AMIDATION; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DEAMINATION; ELECTROSPRAY MASS SPECTROMETRY; FOURIER TRANSFORM MASS SPECTROMETRY; HUMAN; HUMAN CELL; HYPOTHESIS; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LENS; PEPTIDE SYNTHESIS; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RELIABILITY; SAMPLING; SOLID PHASE SYNTHESIS; TEMPERATURE DEPENDENCE; TISSUE DISTRIBUTION;

AMIDES; AMINO ACID SUBSTITUTION; BACTERIA; BETA-CRYSTALLIN B CHAIN; FOURIER ANALYSIS; GLUTAMIC ACID; GLUTAMINE; HUMANS; LASERS; MASS SPECTROMETRY; MUTATION; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 29644438539     PISSN: 10900535     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Robinson NE, Robinson AB. Molecular clocks: deamidation of asparaginyl and glutaminyl residues in peptides and proteins. Cave Junction (OR): Althouse Press; 2004.
2. Lampi KJ, Ma Z, Hanson SR, Azuma M, Shih M, Shearer TR, Smith DL, Smith JB, David LL. Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometry. Exp Eye Res 1998; 67:31-43.
3. Zhang Z, Smith DL, Smith JB. Human beta-crystallins modified by backbone cleavage, deamidation and oxidation are prone to associate. Exp Eye Res 2003; 77:259-72.
4. Robinson AB, McKerrow JH, Cary P. Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer. Proc Natl Acad Sci U S A 1970; 66:753-7.
5. Robinson AB, Rudd CJ. Deamidation of glutaminyl and asparaginyl residues in peptides and proteins. Curr Top Cell Regul 1974; 8:247-95.
6. Robinson NE, Robinson AB. Deamidation of human proteins. Proc Natl Acad Sci U S A 2001; 98:12409-13.
7. Robinson NE. Protein deamidation. Proc Natl Acad Sci U S A 2002; 99:5283-8.
8. Robinson NE, Robinson AB. Amide molecular clocks in drosophila proteins: potential regulators of aging and other processes. Mech Ageing Dev 2004; 125:259-67.
9. Flatmark T. Multiple molecular forms of bovine heart cytochrome c. V.A comparative study of their physicochemical properties and their reactions in biological systems. J Biol Chem 1967; 242:2454-9.
10. Flatmark T, Sletten K. Multiple forms of cytochrome c in the rat. Precursor-product relationship between the main component Cy I and the minor components Cy II and Cy 3 in vivo. J Biol Chem 1968; 243:1623-9.
11. Robinson AB, McKerrow JH, Legaz M. Sequence dependent deamidation rates for model peptides of cytochrome C. Int J Pept Protein Res 1974; 6:31-5.
12. Midelfort CF, Mehler AH. Deamidation in vivo of an asparagine residue of rabbit muscle aldolase. Proc Natl Acad Sci U S A 1972; 69:1816-9.
13. McKerrow JH, Robinson AB. Primary sequence dependence of the deamidation of rabbit muscle aldolase. Science 1974; 183:85.
14. Gracy RW, Lu HS, Yuan PM, Talent JM. Structural analysis of altered proteins. In Adelman RC, Roth GS, editors. Altered Proteins and Aging. Boca Raton (FL): CRC Press; 1983. p27-34.
15. Gracy RW, Talent JM, Zvaigzne AI. Molecular wear and tear leads to terminal marking and the unstable isoforms of aging. J Exp Zool 1998; 282:18-27.
16. Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosova I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, Weintraub SJ. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 2002; 111:51-62. Erratum in: Cell. 2003; 115:503.
17. Weintraub SJ, Manson SR, Deverman BE. Resistance to antineoplastic therapy. The oncogenic tyrosine kinase-Bcl-x(L) axis. Cancer Cell 2004; 5:3-4.
18. Takemoto L, Boyle D. Deamidation of specific glutamine residues from alpha-A crystallin during aging of the human lens. Biochemistry 1998; 37:13681-5.
19. Lapko VN, Purkiss AG, Smith DL, Smith JB. Deamidation in human gamma S-crystallin from cataractous lenses is influenced by surface exposure. Biochemistry 2002; 41:8638-48.
20. Lampi KJ, Kim YH, Bachinger HP, Boswell BA, Lindner RA, Carver JA, Shearer TR, David LL, Kapfer DM. Decreased heat stability and increased chaperone requirement of modified human betaB1-crystallins. Mol Vis 2002; 8:359-66 .
21. Harms MJ, Wilmarth PA, Kapfer DM, Steel EA, David LL, Bachinger HP, Lampi KJ. Laser light-scattering evidence for an altered association of beta B1-crystallin deamidated in the connecting peptide. Protein Sci 2004; 13:678-86.
22. Takemoto L, Boyle D. Increased deamidation of asparagine during human senile cataractogenesis. Mol Vis 2000; 6:164-8 .
23. Srivastava OP, Srivastava K. Existence of deamidated alphaB-crystallin fragments in normal and cataractous human lenses. Mol Vis 2003; 9:110-8 .
24. Searle BC, Dasari S, Wilmarth PA, Turner M, Reddy AP, David LL, Nagalla SR. Identification of protein modifications using MS/MS de novo sequencing and the OpenSea alignment algorithm. J Proteome Res 2005 Mar-Apr; 4:546-54.
25. Robinson NE, Robinson AB. Molecular clocks. Proc Natl Acad Sci U S A 2001; 98:944-9.
26. Robinson NE, Robinson AB, Merrifield RB. Mass spectrometric evaluation of synthetic peptides as primary structure models for peptide and protein deamidation. J Pept Res 2001; 57:483-93.
27. Robinson NE, Robinson ZW, Robinson BR, Robinson AL, Robinson JA, Robinson ML, Robinson AB. Structure-dependent nonenzymatic deamidation of glutaminyl and asparaginyl pentapeptides. J Pept Res 2004; 63:426-36.
28. Schmid DG, von der Mulbe FD, Fleckenstein B, Weinschenk T, Jung G. Broadband detection electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry to reveal enzymatically and chemically induced deamidation reactions within peptides. Anal Chem 2001; 73:6008-13.
29. Cournoyer JJ, Pittman JL, Ivleva VB, Fallows E, Waskell L, Costello CE, O'Connor PB. Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation. Protein Sci 2005; 14:452-63.
30. Capasso S, Balboni G, Di Cerbo P. Effect of lysine residues on the deamidation reaction of asparagine side chains. Biopolymers 2000; 53:213-9.
31. Capasso S, Di Cerbo P. Kinetic and thermodynamic control of the relative yield of the deamidation of asparagine and isomerization of aspartic acid residues. J Pept Res 2000; 56:382-7.
32. Lampi KJ, Oxford JT, Bachinger HP, Shearer TR, David LL, Kapfer DM. Deamidation of human beta B1 alters the elongated structure of the dimer. Exp Eye Res 2001; 72:279-88.
33. Lampi KJ, Ma Z, Shih M, Shearer TR, Smith JB, Smith DL, David LL. Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. J Biol Chem 1997; 272:2268-75.