Simultaneous determination of ten amphetamine designer drugs in human whole blood by capillary electrophoresis with diode array detection

Biomedical Chromatography

Volumn 19, Issue 10, 2005, Pages 737-742

  Nieddu, Maria ^a   Boatto, Gianpiero ^a   Carta, Antonio ^a   Sanna, Alessandro ^a   Pisano, Milena ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Amphetamines; Capillary electrophoresis; Designer drugs; Diode array detection; Whole blood

Indexed keywords

BLOOD; BLOOD VESSELS; DIODES; DRUG PRODUCTS; ULTRAVIOLET SPECTROSCOPY;

AMPHETAMINE; DESIGNER DRUGS; DIODE ARRAY DETECTION; DRUG MARKETS; ILLICIT DRUG; LARGE GROUPS; MIGRATION TIME; PHENETHYLAMINES; SIMULTANEOUS DETERMINATIONS; WHOLE BLOOD;

CAPILLARY ELECTROPHORESIS;

2,5 DIMETHOXY 4 METHYLAMPHETAMINE; 2,5 DIMETHOXYAMPHETAMINE; 4 BROMO 2,5 DIMETHOXYAMPHENETHYLAMINE; 4 CHLORO 2,5 DIMETHOXYAMPHETAMINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 4 IODO 2,5 DIMETHOXYPHENETHYLAMINE; 4 METHYL 2,5 DIMETHOXYAMPHENETHYLAMINE; 4 NITRO 2,5 DIMETHOXYAMPHENETHYLAMINE; 4 NITRO 2,5 DIMETHOXYAMPHETAMINE; AMPHETAMINE; AMPHETAMINE DERIVATIVE; BROLAMFETAMINE; DESIGNER DRUG; PHOSPHATE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; BLOOD SAMPLING; CALIBRATION; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIODE LASER; DRUG DETERMINATION; HUMAN; IN VIVO STUDY; MALE; NONHUMAN; PH; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY; STRUCTURE ANALYSIS; VALIDATION PROCESS;

ANIMALIA;

EID: 29544447369     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.508     Document Type: Article

References (30)

1. Altria K. Analysis of Pharmaceutical by Capillary Electrophoresis. Chromatographia CE Series, Vol. 2. Vieweg: Braunschweig, 1998.
2. Boatto G, Faedda MV, Pau A, Asproni B, Menconi S and Cerri R. Determination of amphetamines in human whole blood by capillary electrophoresis with photodiode array detection. Journal of Pharmaceutical and Biomedical Analysis 2002; 29: 1073.
3. Christophersen AS. Amphetamine designer drugs - an overview and epidemiology. Toxicology Letters 2000; 112-1113: 127.
4. Di Pietra AM, Gotti R, Del Borrello E, Pomponio R and Cavrini V. Analysis of amphetamine and congeners in illicit samples by liquid chromatography and capillary electrophoresis. Journal of Analytical Toxicology 2001; 25: 99.
5. Felscher D and Schulz K. Screening of amphetamine/methamphetamine and their derivatives in urine using FPIA and Triage 8 and the Scope and limits of a subsequent identification by means of the REMEDi HS system. Journal of Forensic Science 2000; 45: 1327.
6. Furnari C, Ottaviano V and Rosati F. Determination of 4-bromo-2,5-dimethoxyamphetamine (DOB) found in illicit tablets seized in Italy. Annali Dell'Istituto Superiore Di Sanità 2001; 37: 297.
7. Garcia-Repetto R, Moreno E, Soriano T, Jurado C, Gimnenez MP and Menendez M. Tissue concentrations of MDMA in three fatal case of overdose. Forensic Science International 2003; 135: 110.
8. Giroud C, Augsburger M, Rivier L, Mangin P, Sadeghipour F, Varesio E, Veuthey JL and Kamalaprija P. 2C-B: a new psychoactive phenylethylamine recently discovered in ecstasy tablets sold on the swiss black market. Journal of Analytical Toxicology 1998; 22: 345.
9. HelmLin HJ, Bracher K, Bourquin D, Vonlanthen D, Brenneisen R and Styck J. Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and ist metabolites in plasma and urine by HPLC-DAD and GC-MS. Journal of Analytical Toxicology 1996: 20: 432.
10. Kamamori T, Inoue H, Iwata Y, Ohmae Y and Kishi T. In vivo metabolism of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in the rat: identification of urinary metabolites. Journal of Analytical Toxicology 2001; 26: 61.
11. Lurie IS, Bethea MJ, McKibben TD, Hays PA, Pellegrini P, Sahai R, Garcia AD and Weinberger R. Use of dynamically coated capillaries for the routine analysis of methamphetamine, amphetamine, MDA, MDMA, MDEA, and cocaine using capillary electrophoresis. Journal of Forensic Science 2001; 46: 1025.
12. Luzzi VI, Saunders AN, Koenig JW, Turk J, Lo SF, Garg UC and Dietzen DJ. Analytical performance of immunoassays for drugs of abuse below established cutoff values. Clinical Chemistry 2004; 50: 717.
13. Manetto G, Tagliaro F, Crivellente F, Pascali VL and Marigo M. Field-amplified sample stacking capillary zone electrophoresis applied to the analysis of opiate drugs in hair. Electrophoresis 2000; 21: 2891.
14. Mortier KA, Dams R, Lambert WE, De Letter EA, Van Calenbergh S and Leenheer AP. Determination of paramethoxyamphetamine and other amphetamine-related designer drugs by liquid chromatography/sonic spray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2002; 16: 865.
15. Nichols DE. Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. Journal of Psychoactive Drugs 1986; 18: 305.
16. Nishida M, Namera A, Yashiki M and Tohru K, On-column derivatization for determination of amphetamine and methamphetamine in human blood by gas chromatography-mass spectrometry. Forensic Science International 2002; 125: 156.
17. Nishida M, Namera A, Yashiki M and Tohru K. Routine analysis of amphetamine and methamphetamine in biological materials by gas chromatography/mss spectrometry and on-column derivatization. Journal of Chromatography B, Analytical Technology in Biomedicine and Life Sciences 2003; 789: 65.
18. Nordgren HK and Beck O. Direct screening of urine for MDMA and MDA by liquid chromatography-tandem mass spectrometry. Journal of Analytical Toxicology 2003; 27: 15.
19. Owen ML, Baker GB, Coutts RT and Dewhurst WG. Analysis of p-chloroamphetamine and a side-chain monofluorinated analogue in rat brain. Journal of Pharmacological Methods 1991; 25: 147.
20. Peters FT, Samyn N, Wahl M, Kraemer T, De Boeck G and Maurer HH. Concentrations and ratios of amphetamine, methamphetamine, MDA, MDMA, and MDEA enantiomers determined in plasma samples from clinical toxicology and driving under the influence of drugs cases by GC-NICI-MS. Journal of Analytical Toxicology 2003a; 27: 552.
21. Peters FT, Schaefer S, Staack RF, Kraemer T and Maurer HH. Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry. Journal of Mass Spectrometry 2003b; 38: 659.
22. Raikos N, Christopoulou K, Theodoridis G, Tsoukali H and Psaroulis D. Determination of amphetamines in human urine by headspace solid-phase microextraction and gas chromatography. Journal of Chromatography B, Analytical Technology in Biomedicine and Life Sciences 2003; 789: 59.
23. Sato M, Hida M and Nagase H. Analysis of dimethylamphetamine and its metabolites in human urine by liquid chromatography/electrospray ionization mass spectrometry with direct sample injection. Forensic Science International 2002; 128: 146.
24. Schaler RC and Padden JJ. Identification of hallucinogens in illicit seizures. I. 2,5-Dimethoxyamphetamine. Journal of Pharmaceutical Science 1972; 61: 1851.
25. Shulgin A and Shulgin A. Pihkal. A Chemical Love Story. Transform Press: Berkeley, CA, 1998.
26. Soares ME, Carvalho M, Carmo H, Remiao F, Carvalho F and Bastos ML. Simultaneous determination of amphetamine derivatives in human urine after SPE extraction and HPLC-UV analysis. Biomedical Chromatography 2004; 18: 125.
27. Stout PR, Klette KL and Wiegand R. Comparison and evaluation of DRI methamphetamine, DRI ecstasy, Abuscreen ONLINE amphetamine, and a modified Abuscreen ONLINE amphetamine screening immunoassays for the detection of amphetamine (AMP), methamphetamine (MTH), 3,4-methylenedioxyamphetamine (MDA), and 3,4-methylenedioxymethamphetamine (MDMA) in human urine. Journal of Analytical Toxicology 2003; 27: 265.
28. Swartz MS, Swanson JW and Hannon MJ. Detection of illicit substance use among persons with schizophrenia by radioimmunoassay of hair. Psychiatric Service 2003; 54: 891.
29. USP. 23 NF18. Validation of Compendial Methods, Vol. 7, 1995; 1983.
30. Wills S. Drugs of Abuse, 1st ed. The Pharmaceutical Press: London, 1997; 61.