Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia

Human and Experimental Toxicology

Volumn 24, Issue 12, 2005, Pages 643-654

  Burns Naas, Leigh Ann ^a,k   Zorbas, M ^a   Jessen, B ^a   Evering, W ^a   Stevens, G ^a   Ivett, J L ^b   Ryan, T E ^c   Cook, J C ^a   Capen, C C ^d   Chen, M ^a,h   Furman, G ^a   Theiss, J C ^e,i   Webber, S ^e,j   Wu, E ^a   Shetty, B ^a   Gasser, R ^f   McClain, R M ^g  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Department of Genetic and Molecular Toxicology   (United States)

^c 206 Carnegie Center   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e AGOURON PHARMACEUTICALS INC   (United States)

^f F HOFFMANN LA ROCHE LTD   (Switzerland)

^g McClain Associates   (United States)

^h GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

ⁱ Sun Coast Tox   (United States)

^j Stephanie Webber Consulting   (United States)

^k PFIZER INC   (United States)

more..

Author keywords

Antiviral; Carcinogenicity; HIV; Nelfinavir; T3; T4; Thyroid gland function; Thyroid hormone; Thyroxine

Indexed keywords

CYTOCHROME P450 3A4; NELFINAVIR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANCER INCIDENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CARCINOGENICITY; DRUG CLEARANCE; FEMALE; GENE EXPRESSION REGULATION; HORMONE ACTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROID FOLLICULAR CARCINOMA; THYROID FUNCTION; THYROID TUMOR; TISSUE SLICE; TUMOR LOCALIZATION;

ADENOCARCINOMA, FOLLICULAR; ADMINISTRATION, ORAL; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARCINOGENICITY TESTS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HIV PROTEASE INHIBITORS; HYPERPLASIA; LONGEVITY; MALE; NELFINAVIR; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPECIES SPECIFICITY; THYROID GLAND; THYROID HORMONES; THYROID NEOPLASMS; THYROXINE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 29444459912     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327105ht568oa     Document Type: Article

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