Enhanced expression of the local haematopoietic bone marrow renin-angiotensin system in polycythemia rubra vera

Journal of International Medical Research

Volumn 33, Issue 6, 2005, Pages 661-667

  Aksu, S ^a   Beyazit, Y ^a   Haznedaroglu, I C ^a   Kekilli, M ^a   Canpinar, H ^a   Misirlioglu M ^b   Uner, A ^a   Tuncer, S ^b   Sayinalp, N ^a   Buyukasik Y ^a   Goker, H ^a   Ozcebe, O I ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Metis Biotechnology Ltd   (Turkey)

Author keywords

Angiotensin converting enzyme; Erythropoiesis; Flow cytometry; Polycythemia rubra vera; Real time polymerase chain reaction; Renin angiotensin system

Indexed keywords

ANGIOTENSINOGEN; COMPLEMENTARY DNA; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; RAS PROTEIN; RENIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; ENZYME ANALYSIS; ERYTHROPOIESIS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MALE; POLYCYTHEMIA VERA; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA ISOLATION; UPREGULATION;

EID: 29444434005     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000503300608     Document Type: Article

References (25)

1. Haznedaroglu IC, Tuncer S, Gursoy M: A local renin-angiotensin system in the bone marrow. Med Hypotheses 1996; 46: 507-510.
2. Haznedaroglu IC: A local renin-angiotensin system in the bone marrow: hypothesis and clues. Exp Hematol 1999; 27: 186-187.
3. Haznedaroglu IC: A local renin-angiotensin system in the bone marrow still awaits its Christopher Columbus. Exp Hematol 1998; 26: 279.
4. Vasku A, Holla L, Znojil V: The best model of a cat is a cat, especially the same cat. Exp Hematol 1999; 27: 187-188.
5. Haznedaroglu IC, Ozturk MA: Towards the understanding of the local hematopoietic bone marrow renin-angiotensin system. Int J Biochem Cell Biol 2003; 35: 867-880.
6. Strawn WB, Richmond RS, Ann TE, Gallagher PE, Ferrario CM: Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells. Br J Haematol 2004; 126: 120-126.
7. Richmond RS, Tallant EA, Gallagher PE, Ferrario CM, Strawn WB: Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells. J Renin Angiotensin Aldosterone Syst 2004; 5: 176-182.
8. Haznedaroglu IC, Arici M, Buyukasik Y: A unifying hypothesis for the renin-angiotensin system and hematopoiesis: sticking the pieces together with the JAK-STAT pathway. Med Hypotheses 2000; 54: 80-83.
9. Haznedaroglu IC, Gullu IH: Hematological side effects of ACE inhibitors and a hypothetical local renin-angiotensin system in the bone marrow. Nephron 1997; 77: 111.
10. Marusic-Vrsalovic M, Dominis M, Jaksic B, Kusec R: Angiotensin I-converting enzyme is expressed by erythropoietic cells of normal and myeloproliferative bone marrow. Br J Haematol 2003; 123: 539-541.
11. Michiels JJ, Barbui T, Finazzi G, Fuchtman SM, Kutti J, Rain JD, et al. Diagnosis and treatment of polycythemia vera and possible future study designs of the PVSG. Leuk Lymphoma 2000; 36: 239-253.
12. Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.
13. Rodgers KE, Xiong S, Steer R, diZerega GS: Effect of angiotensin II on hematopoietic progenitor cell proliferation. Stem Cells 2000; 18: 287-294.
14. Haznedaroglu I, Tokgozoglu L, Caglar M, Kes S: Local cardiac renin-angiotensin system and hypertensive heart disease. Hypertension 1994; 24: 816-818.
15. Haznedaroglu IC: Angiotensin I-converting enzyme, blood groups, and a local marrow-specific renin-angiotensin system. Exp Hematol 1997; 25: 93.
16. Goker H, Haznedaroglu IC, Beyazit Y, Aksu S, Tuncer S, Misirlioglu L, et al: Local umbilical cord blood renin-angiotensin system. Ann Hematol 2005; 84: 277-281.
17. Cobankara V, Ozturk MA, Kiraz S, Ertenli I, Haznedaroglu I, Pay S, et al: Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis. Rheumatol Int 2005; 25: 285-291.
18. Ozturk MA, Guven GS, Haznedaroglu IC: How hematopoietic stem cells know and act in cardiac microenvironment for stem cell plasticity? Impact of local renin-angiotensin systems. Med Hypotheses 2004; 63: 866-874.
19. Charrier S, Michaud A, Badaoui S, Giroux S, Ezan E, Sainteny F, et al: Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells. Blood 2004; 104: 978-985.
20. Haznedaroglu IC, Arici M, Buyukasik Y: A unifying hypothesis for the renin-angiotensin system and hematopoiesis: sticking the pieces together with the JAK-STAT pathway. Med Hypotheses 2000; 54: 80-83.
21. Abali H, Haznedaroglu IC, Goker H, Celik I, Oztali D, Koray Z, et al: Circulating and local bone marrow renin-angiotensin system in leukemic hematopoiesis: preliminary evidences. Hematology 2002; 7: 75-82.
22. Wulf GG, Jahns-Streubel G, Nobiling R, Strutz F, Hemmerlein B, Hiddemann W, et al: Renin in acute myeloid leukaemia blasts. Br J Haematol 1998; 100: 335-337.
23. Cole J, Ertoy D, Lin H, Sutliff RL, Ezan E, Guyenne TT, et al: Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. J Clin Invest 2000; 106: 1391-1398.
24. Haznedaroglu IC, Buyukasik Y: Current evidence for the existence of a local renin-angiotensin system affecting physiological and pathological haemopoiesis in the bone marrow. Br J Haematol 1997; 99: 471.
25. Haznedaroglu IC: Postrenal transplant erythrocytosis, ACE inhibitors and a hypothetical local renin-angiotensin system in the bone marrow. Clin Nephrol 1997; 48: 60.